Browsing Department of Clinical Science by Title
Now showing items 2307-2326 of 2576
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Spiral Vein-Graft Technique is a durable therapeutic option for Popliteal Artery Aneurysms
(Conference poster, 2021) -
Spirometry in chronic obstructive pulmonary disease in Norwegian general practice
(Journal article; Peer reviewed, 2020)Background General practitioners (GPs) in Norway increasingly use spirometry diagnostically as well as in follow up of patients with respiratory complaints, but little is known about their skills and knowledge in this ... -
Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis
(Journal article; Peer reviewed, 2021)Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused ... -
Spontanrapportering av bivirkninger hos barn i Norge for perioden 1998-2007
(Master thesis, 2009-05-19)Legemidler har tidligere blitt brukt hos barn, fra 0 tom 17 år, uten at disse har blitt tilstrekkelig testet og/eller mangler formulering og autorisasjon til å bli brukt i denne populasjonen. Et nytt europeisk regulativ ... -
Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
(Peer reviewed; Journal article, 2019-09-17)Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are debilitating events and spur disease progression. Infectious causes are frequent; however, it is unknown to what extent exacerbations are caused ... -
Stability of glycoprotein gene sequences of herpes simplex virus type 2 from primary to recurrent human infection, and diversity of the sequences among patients attending an STD clinic
(Peer reviewed; Journal article, 2014-02-06)Background: Herpes simplex virus type 2 (HSV-2) is sexually transmitted, leading to blisters and ulcers in the genito-anal region. After primary infection the virus is present in a latent state in neurons in sensory ganglia. ... -
Stability of glycoprotein gene sequences of herpes simplex virus type 2 from primary to recurrent human infection, and diversity of the sequences among patients attending an STD clinic
(Peer reviewed; Journal article, 2014-02-06)Background: Herpes simplex virus type 2 (HSV-2) is sexually transmitted, leading to blisters and ulcers in the genito-anal region. After primary infection the virus is present in a latent state in neurons in sensory ganglia. ... -
Stage 1 hypertension, sex, and acute coronary syndromes during midlife: the Hordaland Health Study
(Journal article; Peer reviewed, 2022)Aims: Hypertension has been suggested as a stronger risk factor for acute coronary syndromes (ACS) in women than men. Whether this also applies to stage 1 hypertension [blood pressure (BP) 130–139/80–89 mmHg] is not ... -
Stage-dependent prognostic shift in mismatch repair-deficient tumors: Assessing patient outcomes in stage II and III colon cancer
(Journal article; Peer reviewed, 2022)Introduction: Deficient mismatch repair (dMMR) or high microsatellite instability (MSI-H) is associated with an improved prognosis in colon cancer stage II but poor prognosis in stage IV colon cancer. The clinical significance ... -
Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss
(Journal article; Peer reviewed, 2021)Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells ... -
Starvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells
(Journal article; Peer reviewed, 2021)Perinatal exposure to starvation is a risk factor for development of severe retinopathy in adult patients with diabetes. However, the underlying mechanisms are not completely understood. In the present study, we shed light ... -
Stathmin Protein Level, a Potential Predictive Marker for Taxane Treatment Response in Endometrial Cancer
(Peer reviewed; Journal article, 2014-02-25)Stathmin is a prognostic marker in many cancers, including endometrial cancer. Preclinical studies, predominantly in breast cancer, have suggested that stathmin may additionally be a predictive marker for response to ... -
Statistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions
(Journal article; Peer reviewed, 2021)The human microbiome has emerged as a central research topic in human biology and biomedicine. Current microbiome studies generate high-throughput omics data across different body sites, populations, and life stages. Many ... -
Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer
(Peer reviewed; Journal article, 2012-06-15)Background: Steroid receptor coactivators (SRCs) may modulate estrogen receptor (ER) activity and the response to endocrine treatment in breast cancer, in part through interaction with growth factor receptor signaling ... -
Steroidogenic factor 1 (NR5A1) induces multiple transcriptional changes during differentiation of human gonadal-like cells
(Journal article; Peer reviewed, 2022)Nuclear receptor subfamily 5 group A member 1 (NR5A1) encodes steroidogenic factor 1 (SF1), a key regulatory factor that determines gonadal development and coordinates endocrine functions. Here, we have established a stem ... -
Stimulated monocyte IL-6 secretion predicts survival of patients with head and neck squamous cell carcinoma
(Peer reviewed; Journal article, 2008-01-30)Background This study was performed in order to determine whether monocyte in vitro function is associated with presence, stage and prognosis of head and neck squamous cell carcinoma (HNSCC) disease. Methods Prospective ... -
Strategies for improving Influenza vaccines: insights from the Influenza A H1N1 and SARS-CoV-2 pandemics
(Doctoral thesis, 2022-09-23)Influensa er et luftveisvirus som kan forårsake alvorlig sykdom og under stadig forandring (drift). Dagens influensavaksiner gir begrenset beskyttelse mot slike driftede influensavirus. Dette fører til at vaksinesammensetningen ... -
Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis
(Journal article; Peer reviewed, 2023)Objective To identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. Methods A previously established SNP dataset derived from DNA sequencing ... -
Streptococcus dysgalactiae Bloodstream Infections, Norway, 1999-2021
(Journal article; Peer reviewed, 2023)Streptococcus dysgalactiae increasingly is recognized as a pathogen of concern for human health. However, longitudinal surveillance data describing temporal trends of S. dysgalactiae are scarce. We retrospectively identified ... -
Strong Association between Diarrhea and Concentration of Enterotoxigenic Escherichia coli Strain TW10722 in Stools of Experimentally Infected Volunteers
(Journal article; Peer reviewed, 2023)Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal illness in children and travelers in low- and middle-income countries. When volunteers are infected with ETEC strains, as part of experimental ...