Browsing Department of Clinical Science by Title
Now showing items 2327-2346 of 2536
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Symptoms and antecedents of autism in children born extremely premature: a national population-based study
(Journal article; Peer reviewed, 2022)The objective of this study is to investigate the prevalence of autism (ASD) symptoms, i.e. , social difficulties, repetitive behaviors, and communicational problems, among children born extremely preterm (EP) compared to ... -
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
(Journal article; Peer reviewed, 2020)Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted ... -
Synthesis of some 1-substituted 5,5-diethoxy-2,2-(propyl-1,3-disulfanyl)pentane-1,4-diols from 1,1-diethoxy-3-(1,3-dithian-2-yl)-propan-2-ol
(Master thesis, 2009-05-20)The starting material for this investigation was 3,3,4,4-tetraethoxybut-1-yne (TEB). This compound is highly functionalized as it contains a triple bond, a protected ketone, and a protected aldehyde, and can undergo a ... -
A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function in Geriatric Patients
(Journal article; Peer reviewed, 2022)Background Cognitive decline is common in older people. Numerous studies point to the detrimental impact of polypharmacy and inappropriate medication on older people’s cognitive function. Here we aim to systematically ... -
A systematic review of total IgE reference intervals − A 2024 update
(Journal article; Peer reviewed, 2025)Background Total IgE (tIgE) is a frequently requested analyte in patients presenting with symptoms of atopy. Although tIgE has limited clinical utility in the diagnosis of atopic diseases, it is still important that ... -
Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy
(Journal article; Peer reviewed, 2023)Context Graves disease (GD) is one of the most common autoimmune disorders. Recent literature has shown an immune response involving several different inflammatory related proteins in these patients. Objective This ... -
Systemic Cardiac Troponin T Associated With Incident Atrial Fibrillation Among Patients With Suspected Stable Angina Pectoris
(Journal article; Peer reviewed, 2020)Higher concentrations of cardiac troponin T are associated with coronary artery disease (CAD) and adverse cardiovascular prognosis. The relation with incident atrial fibrillation (AF) is less explored. We studied this ... -
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
(Journal article; Peer reviewed, 2020)Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective ... -
Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study
(Journal article; Peer reviewed, 2023)Objective Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct ... -
Systemic inflammation in psoriasis: Circulating immune cells and cytokines
(Doctoral thesis, 2019-09-27)Psoriasis is a common, chronic inflammatory skin disease associated with arthritis and multiple comorbidities. Autoantigens in the skin elicit a response in cytotoxic T cells, leading to local inflammation and recruitment ... -
Systemic inflammatory markers as predictors of longitudinal outcomes in COPD : Results from the Bergen COPD Cohort Study
(Doctoral thesis, 2021-06-02)Background: Chronic obstructive pulmonary disease (COPD) is major cause of morbidity and mortality worldwide. The prevalence is increasing worldwide, as a result of an increase in cigarette smoking the last decades. The ... -
Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1
(Journal article; Peer reviewed, 2023)Autoimmune polyendocrine syndrome type I (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene and characterised clinically by multiple autoimmune manifestations and serologically by autoantibodies against ... -
Systemic levels of the endothelium-derived soluble adhesion molecules endocan and E-selectin in patients with suspected deep vein thrombosis
(Peer reviewed; Journal article, 2014-09-30)The initial evaluation of patients with suspected deep vein thrombosis includes the use of biomarkers reflecting activation of the coagulation system. However, the thromboembolic process and neighboring inflammatory responses ... -
The systemic metabolic profile early after allogeneic stem cell transplantation: Effects of adequate energy support administered through enteral feeding tube
(Journal article; Peer reviewed, 2020)Patients undergoing allogeneic stem cell transplantation usually require nutritional support. There is no consensus on whether enteral support through tube feeding should be preferred. A recent randomized study could not ... -
Systemic metabolomic profiles in adult patients with bacterial sepsis: Characterization of patient heterogeneity at the time of diagnosis
(Journal article; Peer reviewed, 2023-01-24)Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The ... -
Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy
(Peer reviewed; Journal article, 2019-10-10)Acute myeloid leukemia (AML) is an aggressive malignancy, and many elderly/unfit patients cannot receive intensive and potentially curative therapy. These patients receive low-toxicity disease-stabilizing treatment. The ... -
Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
(Journal article; Peer reviewed, 2023)Background: Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF ... -
The systemic profile of soluble immune mediators in patients with myelodysplastic syndromes
(Peer reviewed; Journal article, 2016-07-05)Introduction: Myelodysplastic syndromes (MDS) are characterized by bone marrow failure due to disturbed bone marrow maturation. MDS is associated with increased risk of transformation to acute myeloid leukemia (AML) and ... -
Systolic myocardial function measured by echocardiographic speckle-tracking and peak oxygen consumption in pediatric childhood cancer survivors—a PACCS study
(Journal article; Peer reviewed, 2023)Background: Cancer therapy-related cardiotoxicity is a major cause of cardiovascular morbidity in childhood cancer survivors. The aims of this study were to investigate systolic myocardial function and its association to ... -
T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ
(Peer reviewed; Journal article, 2017-07)Next generation sequencing of T and B cell receptors is emerging as a valuable and effective method to diagnose and monitor hematopoietic malignancies. So far, this approach has not been fully explored in regard to autoimmune ...