Blar i Department of Clinical Science på tittel

Viser treff 290-309 av 2291

    • Causal Analysis of World Health Organization's Surgical Safety Checklist Implementation Quality and Impact on Care Processes and Patient Outcomes: Secondary Analysis From a Large Stepped Wedge Cluster Randomized Controlled Trial in Norway 

      Haugen, Arvid Steinar; Wæhle, Hilde Valen; Almeland, Stian Kreken; Harthug, Stig; Sevdalis, Nick; Eide, Geir Egil; Nortvedt, Monica Wammen; Smith, Ingrid; Softeland, Eirik (Peer reviewed; Journal article, 2019)
      Objective: We hypothesize that high-quality implementation of the World Health Organization's Surgical Safety Checklist (SSC) will lead to improved care processes and subsequently reduction of peri- and postoperative ...

    • CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma 

      Kleinmanns, Katrin; Bischof, Katharina; Anandan, Shamundeeswari; Popa, Mihaela Lucia; Akslen, Lars A.; Gjertsen, Bjørn Tore; Karlsen, Ida; Fosse, Vibeke Samuelsen; Bjørge, Line; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)
      Background The survival rate of patients with advanced high-grade serous ovarian carcinoma (HGSOC) remains disappointing. Clinically translatable orthotopic cell line xenograft models and patient-derived xenografts (PDXs) ...

    • CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model 

      Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; de Jalón, Elvira Garcia; Tenstad, Olav; Bjørge, Line; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      Background The completeness of resection is a key prognostic indicator in patients with ovarian cancer, and the application of tumour-targeted fluorescence image-guided surgery (FIGS) has led to improved detection of ...

    • CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without hiv co-infection 

      Andersen, Aase B.; Range, Nyagosya S.; Changalucha, John; PrayGod, George; Kidola, Jeremiah; Grewal, Harleen M. S.; Faurholt-Jepsen, Daniel; Krarup, Henrik; Friis, Henrik (Peer reviewed; Journal article, 2012-03-21)
      Background: The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported. Methods: CD4 counts were assessed from time of diagnosis till the end of TB treatment in a ...

    • CD64 as a potential biomarker in septic arthritis 

      Oppegaard, Oddvar; Skodvin, Brita; Halse, Anne-Kristine; Langeland, Nina (Peer reviewed; Journal article, 2013-06-19)
      Background Traditional inflammatory markers are generally unhelpful in discerning septic arthritis from inflammatory joint disease due to their lack of specificity. We wished to explore the discriminatory power of the novel ...

    • CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors 

      Brenner, Annette; Reikvam, Håkon; Rye, Kristin Paulsen; Hagen, Karen Marie; Lavecchia, Antonio; Bruserud, Øystein (Peer reviewed; Journal article, 2017-03-11)
      Cell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are also involved in chromatin modulation and transcriptional regulation. ...

    • CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup 

      Aasebø, Kristine; Dragomir, Anca; Sundström, Magnus; Mezheyeuski, Artur; Edqvist, Per-Henrik; Eide, Geir Egil; Pontén, Fredrik; Pfeiffer, Per; Glimelius, Bengt; Sorbye, Halfdan (Journal article; Peer reviewed, 2020-02-11)
      Background: Survival of metastatic colorectal cancer (mCRC) patients has improved, but mainly for trial patients. New predictive and prognostic biomarkers validated in the general mCRC population are needed. Caudal-type ...

    • A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation 

      Tadele, Dagim Shiferaw; Robertson, Joseph; Crispin, Richard; Herrera, Carmen; Chlubnová, Markéta; Piechaczyk, Laure Isabelle; Ayuda-Duran, Maria del Pilar; Singh, Sachin Kumar; Gedde-Dahl, Tobias; Fløisand, Yngvar; Skavland, Jørn; Wesche, Jørgen; Gjertsen, Bjørn Tore; Enserink, Jorrit (Journal article; Peer reviewed, 2021)
      Breakpoint Cluster Region-Abelson kinase (BCR–Abl) is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for ...

    • Cell type specificity of neurovascular coupling in cerebral cortex 

      Uhlirova, Hana; Kiliç, Kivilcim; Tian, Peifang; Thunemann, Martin; Desjardins, Michèle; Saisan, Payam A.; Sakadžić, Sava; Ness, Torbjørn Vefferstad; Mateo, Celine; Cheng, Qun; Weldy, Kimberly L.; Razoux, Florence; Vandenberghe, Matthieu; Cremonesi, Jonathan A.; Ferri, Christopher G.L.; Nizar, Krystal; Sridhar, Vishnu B.; Steed, Tyler C.; Abashin, Maxim; Fainman, Yeshaiahu; Masliah, Eliezer; Djurovic, Srdjan; Andreassen, Ole Andreas; Silva, Gabriel A.; Boas, David A.; Kleinfeld, David; Buxton, Richard B.; Einevoll, Gaute; Dale, Anders; Devor, Anna (Peer reviewed; Journal article, 2016-05-31)
      Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation ...

    • Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study 

      Chuang, Shu-Chun; Boeing, Heiner; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Bueno-de-Mesquita, Bas; Lajous, Martin; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Kaaks, Rudolf; Küehn, Tilman; Pischon, Tobias; Drogan, Dagmar; Tjønneland, Anne; Overvad, Kim; Quirós, J. Ramón; Agudo, Antonio; Molina-Montes, Esther; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nicholas J.; Travis, Ruth C.; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Mattiello, Amalia; Peeters, Petra H.; Weiderpass, Elisabete; Palmqvist, Richard; Ljuslinder, Ingrid; Gunter, Marc; Lu, Yunxia; Cross, Amanda J.; Riboli, Elio; Vineis, Paolo; Aleksandrova, Krasimira (Peer reviewed; Journal article, 2016-02-25)
      Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). ...

    • Ceramide stearic to palmitic acid ratio predicts incident diabetes 

      Hilvo, Mika; Salonurmi, Tuire; Havulinna, Aki S.; Kauhanen, Dimple; Pedersen, Eva Ringdal; Tell, Grethe S.; Meyer, Klaus; Teeriniemi, Anna-Maria; Laatikainen, Tiina; Jousilahti, Pekka; Savolainen, Markku J.; Nygård, Ottar; Salomaa, Veikko; Laaksonen, Reijo (Peer reviewed; Journal article, 2018-03-15)
      Aims/hypothesis Ceramide lipids have a role in the development of insulin resistance, diabetes and risk of cardiovascular disease. Here we investigated four ceramides and their ratios to find the best predictors of incident ...

    • Cerebral Venous Thrombosis and Hyperthyroidism 

      Knudsen-Baas, Kristin M. (Peer reviewed; Journal article, 2014-01-16)
      Cerebral venous thrombosis (CVT) is mostly caused by pro-thrombotic factors. Hyperthyroidism is not a wellknown risk factor. We present a case report on a 17 year old girl who developed life-threatening CVT after Graves’ ...

    • Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data 

      Vollgraff Heidweiller-Schreurs, Heidweiller-Schreurs; van Osch, Osch; Heymans, Martijn W.; Ganzevoort, Wessel; Schoonmade, L.J.; Bax, C.J.; Mol, Ben W.; de Groot, Christianne J.M.; Bossuyt, Patrick M.M.; de Boer, Boer; Khalil, Asma; Thilaganathan, Basky; Turan, Ozhan M; Crimmins, Sarah; Harman, Chris; Shannon, Alisson M; Kumar, Sailesh; Dicker, Patrick; Malone, Fergal; Tully, Elizabeth C; Unterscheider, Julia; Crippa, Isabella; Ghidini, Alessandro; Roncaglia, Nadia; Vergani, Patrizia; Bhide, Amar; D'Antonio, Francesco; Pilu, Gianluigi; Galindo, Alberto; Herraiz, Ignacio; Vázquez-Sarandeses, Alicia; Ebbing, Cathrine; Johnsen, Synnøve Lian; Karlsen, Henriette Odland (Journal article; Peer reviewed, 2021)
      Objective To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone – standard of practice – for adverse perinatal outcome in singleton pregnancies. Design ...

    • Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients 

      Watne, Leiv Otto; Pollmann, Christian Thomas; Neerland, Bjørn Erik; Quist-Paulsen, Else; Halaas, Nathalie Bodd; Idland, Ane-Victoria; Hassel, Bjørnar; Henjum, Kristi; Knapskog, Anne Brita; Frihagen, Frede; Ræder, Johan; Godø, Aasmund; Ueland, Per Magne; McCann, Adrian; Figved, Paul Wender; Selbæk, Geir; Zetterberg, Henrik; Fei Fang, Evandro; Myrstad, Marius; Giil, Lasse Melvær (Journal article; Peer reviewed, 2022)
      Background: The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute confusion) ...

    • “The challenge is the complexity” – A qualitative study about decision-making in advanced lung cancer treatment 

      Orstad, Silje; Fløtten, Øystein; Madebo, Tesfaye; Gulbrandsen, Pål; Strand, Roger; Lindemark, Frode; Fluge, Sverre; Tilseth, Rune Hørgård; Schaufel, Margrethe Aase (Journal article; Peer reviewed, 2023)
      Introduction The value of shared decision-making and decision aids (DA) has been well documented yet remain difficult to integrate into clinical practice. We wanted to investigate needs and challenges regarding ...

    • Challenges in diagnosing paediatric malaria in Dar es Salaam, Tanzania 

      Strøm, Gro Elizabeth Ann; Haanshuus, Christel Gill; Fataki, Maulidi; Langeland, Nina; Blomberg, Bjørn (Peer reviewed; Journal article, 2013-07-03)
      Background: Malaria is a major cause of paediatric morbidity and mortality. As no clinical features clearly differentiate malaria from other febrile illnesses, and malaria diagnosis is challenged by often lacking laboratory ...

    • Challenges in diagnosing pediatric malaria in Dar es Salaam, Tanzania 

      Strøm, Gro Elizabeth Ann; Haanshuus, Christel Gill; Moyo, Sabrina John; Fataki, Maulidi; Langeland, Nina; Blomberg, Bjørn (Conference poster, 2012-10-15)

    • Change in pulmonary diffusion capacity in a general population sample over 9 years 

      Storebø, Michael Langballe; Eagan, Tomas Mikal; Eide, Geir Egil; Gulsvik, Amund; Thorsen, Einar; Bakke, Per S. (Peer reviewed; Journal article, 2016-09-02)
      Rationale: Data on the change in diffusion capacity of the lung for carbon monoxide (DLCO) over time are limited. We aimed to examine change in DLCO (ΔDLCO) over a 9-year period and its predictors. Methods: A Norwegian ...

    • Change in pulmonary diffusion capacity in a general population sample over 9 years 

      Storebø, Michael Langballe; Eagan, Tomas Mikal; Eide, Geir Egil; Gulsvik, Amund; Thorsen, Einar; Bakke, Per S. (Peer reviewed; Journal article, 2016-09-02)
      Rationale: Data on the change in diffusion capacity of the lung for carbon monoxide (DL_CO) over time are limited. We aimed to examine change in DL_CO (ΔDL_CO) over a 9-year period and its predictors. Methods: A Norwegian ...

    • Changes in cardiopulmonary exercise capacity and limitations 3 to 12 months after COVID-19 

      Ingul, Charlotte Bjørk; Edvardsen, Anne; Follestad, Turid; Trebinjac, Divna; Ankerstjerne, Odd Andre Wathne; Brønstad, Eivind; Rasch-Halvorsen, Øystein; Aarli, Bernt Bøgvald; Dalen, Håvard; Nes, Bjarne; Lerum, Tøri Vigeland; Einvik, Gunnar; Stavem, Knut; Skjørten, Ingunn (Journal article; Peer reviewed, 2023)
      Rationale: To describe cardiopulmonary function during exercise 12 months after hospital discharge for coronavirus disease 2019 (COVID-19), assess the change from 3 to 12 months, and compare the results with matched controls ...