Blar i Department of Clinical Science på tittel

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    • Diffusing capacity of the lung for carbon monoxide. Variability and longitudinal changes over nine years 

      Storebø, Michael Langballe (Doctoral thesis, 2019-03-13)
      Pulmonary gas exchange oxygenates our blood and facilitates transfer of carbon dioxide produced out of the body. Measurement of pulmonary gas exchange by diffusing capacity of the lung for carbon monoxide (DLCO) shows a ...

    • Diffusion tension imaging is a good tool for assessing patients with dementia and behavioral problems and discriminating them from other dementia patients 

      Naik, Mala; Esmaeili, Morteza; Thomas, Owen Matthew Truscott; Geitung, Jonn Terje (Journal article; Peer reviewed, 2021)
      Background Dementia is one of the leading public health concerns as the world’s population ages. Although Alzheimer’s disease (AD) is the most common dementia diagnosis among older patients, some patients have additional ...

    • Diflubenzuron in Atlantic Cod (Gadus morhua) - Multiple Dose Pharmacokinetic Study 

      Erdal, Ane (Master thesis, 2012-05-21)
      Diflubenzuron, a chitin synthesis inhibitor, is used as a parasiticide against sea lice in farmed salmonids. It is administered orally via medicated feed pellets. Due to low bioavailability and biliary secretion of the ...

    • Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure 

      Boorsma, Eva M.; ter Maaten, Jozine M.; Damman, Kevin; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Anker, Stefan D.; Filippatos, Gerasimos; Lang, Chim C.; Metra, Marco; Santos, Karine; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims Recently, dipeptidyl peptidase 3 (DPP3) has been discovered as the peptidase responsible for cleavage of angiotensin (1–7) [Ang (1–7)]. Ang (1–7) is part of the angiotensin-converting enzyme–Ang (1–7)–Mas pathway ...

    • Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey 

      Boge, Ranveig Marie; Haugen, Arvid Steinar; Nilsen, Roy Miodini; Bruvik, Frøydis Kristine; Harthug, Stig (Peer reviewed; Journal article, 2019)
      Background: The Discharge Care Experiences Survey (DICARES) was previously developed to measure quality of discharge care in elderly patients (≥ 65 years). The objective of this study was to test the factorial validity of ...

    • Discovery and characterization of novel STAT3 and androgen receptor inhibitors in prostate cancer cells 

      Hua, Yaping (Doctoral thesis, 2020-05-04)
      Prostate cancer (PCa) recurs and leads to incurable castration-resistant prostate cancer (CRPC) after the failure of androgen deprivation therapies (ADT). CRPC development relies on androgen receptor (AR) signalling. The ...

    • Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy 

      Gjertsen, Bjorn T; Schöffski, Patrick (Peer reviewed; Journal article, 2015)
      Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology. In recent years, several Plk1 inhibitors have ...

    • Discovery of novel candidates for anti- liposarcoma therapies by medium-scale high-throughput drug screening 

      Grad, Iwona; Hanes, Robert; Ayuda-Durán, Pilar; Kuijjer, Marieke Lydia; Enserink, Jorrit; Meza-Zepeda, Leonardo A; Myklebost, Ola (Journal article; Peer reviewed, 2021)
      Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor mutation analysis has not led to significant treatment ...

    • Discovery of novel potential reversible peptidyl arginine deiminase inhibitor 

      Aliko, Ardita; Kaminska, Marta; Falkowski, Katherine; Bielecka, Ewa; Benedyk-Machaczka, Malgorzata; Malicki, Stanislaw; Koziel, Joanna; Wong, Alicia; Bryzek, Danuta; Kantyka, Tomasz Tadeusz; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2019)
      Citrullination, a posttranslational modification, is catalyzed by peptidylarginine deiminases (PADs), a unique family of enzymes that converts peptidyl-arginine to peptidyl-citrulline. Overexpression and/or increased PAD ...

    • Discovery of shared genomic loci using the conditional false discovery rate approach 

      Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Fan, Chun Chieh; Bahrami, Shahram; Holland, Dominic; Djurovic, Srdjan; Thompson, Wesley Kurt; Dale, Anders; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)
      In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated variants have been uncovered, offering new insights into the genetic ...

    • Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination 

      Tete, Sarah; Krammer, Florain; Jalloh, Sarah Larteley Lartey; Bredholt, Geir; Wood, John M.; Skrede, Steinar; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016-07-28)
      Traditionally, neutralising antibodies that are directed to the major surface glycoprotein hemagglutinin (HA) head domain are measured as surrogate correlates of protection against influenza. In addition to neutralization, ...

    • Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors 

      Mullins, Niamh; Kang, JooEun; Campos, Adrian I.; Coleman, Jonathan R.I.; Edwards, Alexis C.; Galfalvy, Hanga; Levey, Daniel F.; Lori, Adriana; Shabalin, Andrey A; Andreassen, Ole; Melle, Ingrid; Morken, Gunnar; Starnawska, Anna; Su, Mei-Hsin; Watson, Hunna J; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonathan; Hishimoto, Akitoyo; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo; Ware, Erin B.; Stephan, Ripke; Bergen, Andrew W.; Berrettini, Wade H.; Bohus, Martin; Brandt, Harry; Chang, Xiao; Chen, Wei J; Chen, Hsi-Chung; Crawford, Steven; Crow, Scott; DiBlasi, Emily; Duriez, Philibert; Fichter, Manfred M; Fernández-Aranda, Fernando; Gallinger, Steven; Glatt, Stephen J.; Gorwood, Philip; Guo, Yiran; Hakonarson, Hakon; Halmi, Katherine A; Hwu, Hai-Gwo; Jain, Sonia; Jamain, Stephane; Jimenez-Murcia, Susana; Johnson, Craig; Djurovic, Srdjan (Journal article; Peer reviewed, 2022)
      Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic ...

    • Distant metastasis dynamics following subsequent surgeries after primary breast cancer removal 

      Demicheli, Romano; Dillekås, Hanna; Straume, Oddbjørn; Biganzoli, Elia (Peer reviewed; Journal article, 2019)
      Background: The aim of the research was to separate the distant metastasis (DM) enhancing effect due to breast tumour removal from that due to surgical manoeuvre by itself. Methods: DM dynamics following surgery for ...

    • Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders 

      Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2017-06-09)
      The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ...

    • Distinct pathophysiological pathways in women and men with heart failure 

      Ravera, Alice; Santema, Bernadet T.; de Boer, Rudolf A.; Anker, Stefan D.; Samani, Nilesh J.; Lang, Chim C.; Ng, Leong; Cleland, John G.F.; Dickstein, Kenneth; Lam, Carolyn S.P.; Van Spall, Harriette G. C.; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Metra, Marco; Voors, Adriaan A.; Sama, Iziah E. (Journal article; Peer reviewed, 2022)
      Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ...

    • Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine 

      Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe; Sulen, André; Reikvam, Håkon; Aarstad, Hans Jørgen; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2013-07-11)
      Background: Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is ...

    • Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy 

      Savic, Miloje; Dembinski, Jennifer Lynn; Laake, Ida; Hungnes, Olav; Cox, Rebecca Jane; Oftung, Fredrik; Trogstad, Lill; Mjaaland, Siri (Peer reviewed; Journal article, 2017-11-16)
      Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not ...

    • Distinct T cell subsets in adipose tissue are associated with obesity 

      Haugstøyl, Martha Eimstad; Cornillet, Martin; Strand, Kristina; Stiglund, Natalie; Sun, Dan; Lawrence-Archer, Laurence; Hjellestad, Iren Drange; Sparrelid, Ernesto; Busch, Christian; Hjelmesæth, Jøran Sture; Hertel, Jens Kristoffer; Ponzetta, Andrea; Mellgren, Gunnar; Fernø, Johan; Björkström, Niklas K. (Journal article; Peer reviewed, 2022)
      Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data ...

    • Distinctions Between Self-Report and Performance-Based Measures of Physical Function in Older Patients Prior to Chemotherapy 

      Torstveit, Ann Helen; Løyland, Borghild; Grov, Ellen Karine; Guren, Marianne; Paul, Steven M.; Ritchie, Christine; Vistad, Ingvild; Miaskowski, Christine; Utne, Inger (Journal article; Peer reviewed, 2021)
      Background: The maintenance of physical function (PF) is an extremely important outcome for older adults. Objective: The aims of this study were to, identify differences in subjective and objective measures of PF between ...

    • Distribution of psychotropic drugs into lipoproteins 

      Serkland, Trond T.; Schjøtt, Jan; Berg, Jon Andsnes; Herfindal, Lars; Riedel, Bettina; Skrede, Silje (Peer reviewed; Journal article, 2019)
      Aim: The aim of this pilot study was to investigate whether psychotropic drugs frequently analyzed in a routine therapeutic drug monitoring laboratory bind to low-density lipoproteins/very-low-density lipoproteins (LDL/VLDL) ...