Blar i Department of Clinical Science på tittel

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    • A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts 

      Gereige, Jessica D.; Xu, Hanfei; Ortega, Victor E.; Cho, Michael H.; Liu, Ming; Sakornsakolpat, Phuwanat; Silverman, Edwin K.; Beaty, Terri H.; Miller, Bruce E.; Bakke, Per S.; Gulsvik, Amund; Hersh, Craig P.; Morrow, Jarrett D.; Ampleford, Elizabeth J.; Hawkins, Gregory A.; Bleecker, Eugene R.; Meyers, Deborah A.; Peters, Stephen P.; Celedón, Juan C.; Tantisira, Kelan; Li, Jiang; Dupuis, Josée; O’connor, George T. (Journal article; Peer reviewed, 2022)
      Introduction Bronchodilator response (BDR) is a measurement of acute bronchodilation in response to short-acting β2-agonists, with a heritability between 10 and 40%. Identifying genetic variants associated with BDR may ...

    • Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth 

      Helgeland, Øyvind; Vaudel, Marc; Juliusson, Petur Benedikt; Holmen, Oddgeir Lingaas; Juodakis, Julius; Bacelis, Jonas; Jacobsson, Bo; Lindekleiv, Haakon; Hveem, Kristian; Lie, Rolv T.; Knudsen, Gun Peggy Strømstad; Stoltenberg, Camilla; Magnus, Per; Sagen, Jørn V.; Molven, Anders; Johansson, Stefan; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2019-10-01)
      Infant and childhood growth are dynamic processes with large changes in BMI during development. By performing genome-wide association studies of BMI at 12 time points from birth to eight years (9286 children, 74,105 ...

    • Genome-wide copy number variation (CNV) in patients with autoimmune Addison’s disease 

      Brønstad, Ingeborg; Wolff, Anette S. B.; Løvås, Kristian; Knappskog, Per; Husebye, Eystein Sverre (Peer reviewed; Journal article, 2011-08-18)
      Background: Addison’s disease (AD) is caused by an autoimmune destruction of the adrenal cortex. The pathogenesis is multi-factorial, involving genetic components and hitherto unknown environmental factors. The aim of the ...

    • Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers 

      Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Athanasiu, Lavinia; Bahrami, Shahram; Bergh, Sverre; Djurovic, Srdjan; Fladby, Tormod; Jarholm, Jonas Alexander; Knapskog, Anne Brita; Pålhaugen, Lene; Saltvedt, Ingvild; Selbæk, Geir; Selnes, Per; Andreassen, Ole; Shadrin, Alexey; Skoog, Ingmar; Soininen, Hilkka; Tsolaki, Magda; Van Broeckhoven, Christine; Van Dongen, Jasper; van Swieten, John C.; Vandenberghe, Rik; Vidal, Jean-Sébastien; Visser, Pieter J.; Vogelgsang, Jonathan; Waern, Margda; Wagner, Michael; Wiltfang, Jens; Wittens, Mandy M.J.; Zetterberg, Henrik; Zulaica, Miren; van Duijn, Cornelia M.; Bjerke, Maria; Engelborghs, Sebastiaan; Jessen, Frank; Teunissen, Charlotte E.; Pastor, Pau; Hiltunen, Mikko; Ingelsson, Martin; Clarimón, Jordi; Sleegers, Kristel; Ruiz, Agustín; Ramirez, Alfredo; Cruchaga, Carlos; Lambert, Jean-Charles; van der Flier, Wiesje M. (Journal article; Peer reviewed, 2022)
      Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European ...

    • Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma 

      Halle, Mari Kyllesø; Sundaresan, Aishwarya; Zhang, Jianqing; Pedamallu, Chandra S.; Srinivasasainagendra, Vinodh; Blair, Jessica; Brooke, Dewey; Bertelsen, Bjørn; Woie, Kathrine; Shrestha, Sadeep; Tiwari, Hemant K.; Wong, Yick Fu; Krakstad, Camilla; Ojesina, Akinyemi I (Journal article; Peer reviewed, 2021)
      Despite recent advances in the prevention of cervical cancer, the disease remains a leading cause of cancer-related deaths in women worldwide. By applying the GISTIC2.0 and/or the MutSig2CV algorithms on 430 whole-exome-sequenced ...

    • Genomic characterization and therapeutic targeting of HPV undetected cervical carcinomas 

      Ruiz, Fiona J.; Sundaresan, Aishwarya; Zhang, Jin; Pedamallu, Chandra S.; Halle, Mari K.; Srinivasasainagendra, Vinodh; Zhang, Jianqing; Muhammad, Naoshad; Stanley, Jennifer; Markovina, Stephanie; Tiwari, Hemant K.; Grigsby, Perry W.; Krakstad, Camilla; Schwarz, Julie K.; Ojesina, Akinyemi I. (Journal article; Peer reviewed, 2021)
      Cervical cancer tumors with undetectable HPV (HPVU) have been underappreciated in clinical decision making. In this study, two independent CC datasets were used to characterize the largest cohort of HPVU tumors to date ...

    • Genomic epidemiology of Streptococcus dysgalactiae subsp. equisimilis strains causing invasive disease in Norway during 2018 

      Kaci, Alba; Jonassen, Christine M; Skrede, Steinar; Sivertsen, Audun; Steinbakk, Martin; Oppegaard, Oddvar (Journal article; Peer reviewed, 2023)
      Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an emerging global pathogen, yet the epidemiology and population genetics of SDSE species have not been extensively characterized. Methods: We ...

    • The Geriatric Prognostic Index: a clinical prediction model for survival of older diffuse large B-cell lymphoma patients treated with standard immunochemotherapy 

      Isaksen, Kathrine Thuestad; Galleberg, Renate Berget; Mastroianni, Maria Adele; Rinde, Marit; Rusten, Leiv Sindre; Barzenje, Dlawer Abdulla; Ramslien, Lloyd Frode; Fluge, Øystein; Jordhøy, Marit Slaaen; Meyer, Peter Albert; Liestøl, Knut; Smeland, Erlend Bremertun; Lingjærde, Ole Christian; Holte, Harald; Brodtkorb, Marianne (Journal article; Peer reviewed, 2023)
      The International prognostic Index (IPI) is the most widely used clinical prediction model for diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone ...

    • Germline pathogenic variants in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms 

      Venizelos, Andreas; Sorbye, Halfdan; Elvebakken, Hege; Perren, Aurel; Lothe, Inger Marie Bowitz; Couvelard, Anne; Hjortland, Geir Olav; Sundlöv, Anna; Svensson, Johanna; Garresori, Herish; Kersten, Christian; Hofsli, Eva; Detlefsen, Sönke; Vestermark, Lene W.; Ladekarl, Morten; Tabaksblat, Elizaveta Mitkina; Knappskog, Stian (Journal article; Peer reviewed, 2023)
      High-grade gastroenteropancreatic (HG-GEP) neuroendocrine neoplasms (NENs) are highly aggressive cancers. The molecular etiology of these tumors remains unclear, and the prevalence of pathogenic germline variants in patients ...

    • Gestational diabetes mellitus follow-up in Norwegian primary health care: a qualitative study 

      Toft, Johanne Holm; Økland, Inger; Furskog-Risa, Christina (Journal article; Peer reviewed, 2022)
      Background Women with gestational diabetes mellitus (GDM) have a tenfold increased risk of developing diabetes, and a high risk of recurrent GDM. Endorsing the life-course approach, aiming to prevent disease and promote ...

    • Getting personal: Can systems medicine integrate scientific and humanistic conceptions of the patient? 

      Vogt, Henrik; Ulvestad, Elling; Eriksen, Thor Eirik; Getz, Linn (Peer reviewed; Journal article, 2014-12)
      Rationale, aims and objectives The practicing doctor, and most obviously the primary care clinician who encounters the full complexity of patients, faces several fundamental but intrinsically related theoretical and practical ...

    • Giant right ventricular outflow tract thrombus in hereditary spherocytosis: a case report 

      Davidsen, Cedric; Larsen, Terje H.; Gerdts, Eva; Lønnebakken, Mai Tone (Peer reviewed; Journal article, 2016-04-26)
      Background: In hereditary spherocytosis with severe anemia, splenectomy is a recommended treatment. However, the spleen carries an important role both in immune function and coagulation. The increased risk of bacterial ...

    • Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome 

      Hanevik, Kurt; Kristoffersen, Einar; Mørch, Kristine; Rye, Kristin Paulsen; Sørnes, Steinar; Svärd, Staffan; Bruserud, Øystein; Langeland, Nina (Peer reviewed; Journal article, 2017-01-28)
      Background: The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform. ...

    • Giardiasis : with emphasis on treatment and post-infectious manifestations 

      Mørch, Kristine (Doctoral thesis, 2010-05-21)

    • Giardiasis treatment: an update with a focus on refractory disease 

      Mørch, Kristine; Hanevik, Kurt (Journal article; Peer reviewed, 2020-10)
      Purpose of review Giardiasis remains a common cause of diarrhea and intestinal enteropathy globally. Here we give an overview of clinical treatment studies and discuss potential mechanisms and molecular targets for ...

    • Global coronary artery plaque area is associated with myocardial hypoperfusion in women with non-ST elevation myocardial infarction 

      Eskerud, Ingeborg; Gerdts, Eva; Nordrehaug, Jan Erik; Lønnebakken, Mai Tone (Peer reviewed; Journal article, 2015-05)
      Background: Women with non-ST elevation myocardial infarction (NSTEMI) have similar extent of myocardial ischemia but less obstructive coronary artery disease (CAD) than their male counterparts. We tested the impact of ...

    • Global left ventricular load in asymptomatic aortic stenosis: covariates and prognostic implication (the SEAS trial) 

      Rieck, Åshild Elseth; Gerdts, Eva; Lønnebakken, Mai Tone; Bahlmann, Edda; Cioffi, Giovanni; Gohlke-Bärwolf, Christa; Ray, Simon; Cramariuc, Dana (Peer reviewed; Journal article, 2012-11-05)
      Introduction: Valvuloarterial impedance (Zva) is a measure of global (combined valvular and arterial) load opposing left ventricular (LV) ejection in aortic stenosis (AS). The present study identified covariates and tested ...

    • Global Lung Function Initiative 2012 reference equations for spirometry in the Norwegian Population 

      Langhammer, Arnulf; Johannessen, Ane; Holmen, Turid Lingaas; Melbye, Hasse; Stanojevic, Sanja; Lund, May Brit; Melsom, Morten Nissen; Bakke, Per S.; Quanjer, Philip (Peer reviewed; Journal article, 2016)
      We studied the fit of the Global Lung Function Initiative (GLI) all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated ...

    • Glucocorticoid pharmacogenetics in Addison's disease - The role of the immunophilin FK506-binding protein (FKBP51) for glucocorticoid sensitivity 

      Hynne, Martha Schei (Master thesis, 2008-05-31)
      There is great variation in the inter-individual sensitivity to glucocorticoids. The immunophilin FK506 binding protein (FKBP51) confers short-loop negative feedback inhibition of the glucocorticoid signalling pathway. ...

    • Glucocorticoid Treatment and Quality of Life in Addison’s disease 

      Øksnes, Marianne (Doctoral thesis, 2014-06-06)
      Addison’s disease (AD) is rare and result in lack of the adrenal hormones cortisol, aldosterone and adrenal androgens. Despite conventional oral replacement therapy, mortality is increased and Health-Related Quality-of-life ...