Blar i Department of Clinical Science på tittel

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    • Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19 

      Trøseid, Marius; Holter, Jan Cato; Holm, Kristian; Vestad, Beate; Sazonova, Taisiia; Granerud, Beathe Kiland; Dyrhol-Riise, Anne Ma; Holten, Aleksander Rygh; Tonby, Kristian; Kildal, Anders Benjamin; Heggelund, Lars; Tveita, Anders Aune; Bøe, Simen; Müller, Karl Erik; Jenum, Synne; Hov, Johannes Espolin Roksund; Ueland, Thor (Journal article; Peer reviewed, 2023)
      Background Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut ...

    • Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin; Otterdal, Kari; Holm, Kristian; Berge, Rolf Kristian; Mollnes, Tom Eirik; Trøseid, Marius; Halvorsen, Bente; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2020)
      A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications of unknown etiology. We have previously shown that systemic inflammation in CVID correlates ...

    • GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility 

      Eriksson, Daniel; Røyrvik, Ellen Christine; Aranda-Guillen, Maribel; Berger, Amund Holte; Landegren, Nils; Artaza, Haydee; Hallgren, Åsa; Grytaas, Marianne; Strøm, Sara; Bratland, Eirik; Botusan, Ileana; Oftedal, Bergithe Eikeland; Breivik, Lars Ertesvåg; Vaudel, Marc; Helgeland, Øyvind; Falorni, Alberto; Jørgensen, Anders Palmstrøm; Hulting, Anna-Lena; Svartberg, Johan; Ekwall, Olov; Fougner, Kristian J; Wahlberg, Jeanette; Nedrebø, Bjørn Gunnar; Dahlqvist, Per; Study group, Norwegian Addison Registry; Study Group, Swedish Addison Registry; Knappskog, Per Morten; Wolff, Anette Susanne Bøe; Bensing, Sophie; Johansson, Stefan; Kämpe, Olof; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2021)
      Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first ...

    • GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores 

      Mullins, Niamh; Bigdeli, Tim B.; Børglum, Anders D.; Coleman, Jonathan R.I.; Demontis, Ditte; Mehta, Divya; Power, Robert A.; Ripke, Stephan; Stahl, Eli A.; Starnawska, Anna; Anjorin, Adebayo; Corvin, Aiden; Sanders, Alan R.; Forstner, Andreas J.; Reif, Andreas; Koller, Anna C.; Świątkowska, Beata; Baune, Bernhard T.; Müller-Myhsok, Bertram; Penninx, Brenda W.J.H.; Pato, Carlos; Zai, Clement; Rujescu, Dan; Hougaard, David M.; Quested, Digby; Levinson, Douglas F.; Binder, Elisabeth B.; Byrne, Enda M.; Agerbo, Esben; Streit, Fabian; Mayoral, Fermin; Bellivier, Frank; Degenhardt, Franziska; Breen, Gerome; Morken, Gunnar; Turecki, Gustavo; Rouleau, Guy A.; Grabe, Hans J.; Völzke, Henry; Jones, Ian; Giegling, Ina; Agartz, Ingrid; Melle, Ingrid; Lawrence, Jacob; Walters, James T.R.; Strohmaier, Jana; Shi, Jianxin; Hauser, Joanna; Biernacka, Joanna M.; Vincent, John B.; Kelsoe, John; Strauss, John S.; Lissowska, Jolanta; Pimm, Jonathan; Smoller, Jordan W.; Guzman-Parra, José; Berger, Klaus; Scott, Laura J.; Jones, Lisa A.; Azevedo, M. Helena; Trzaskowski, Maciej; Kogevinas, Manolis; Rietschel, Marcella; Boks, Marco; Ising, Marcus; Grigoroiu-Serbanescu, Maria; Hamshere, Marian L.; Leboyer, Marion; Frye, Mark; Nöthen, Markus M.; Alda, Martin; Preisig, Martin; Nordentoft, Merete; Boehnke, Michael; O'Donovan, Michael C.; Owen, Michael J.; Pato, Michele T.; Renteriá, Miguel E.; Budde, Monika; Weissman, Myrna M.; Wray, Naomi R.; Bass, Nicholas; Craddock, Nicholas; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Mors, Ole; Gejman, Pablo V.; Sklar, Pamela; McGrath, Patrick; Hoffmann, Per; McGuffin, Peter; Lee, Phil H.; Mortensen, Preben Bo; Kahn, René S.; Ophoff, Roel A.; Adolfsson, Rolf; Van der Auwera, Sandra; Djurovic, Srdjan; Kloiber, Stefan; Heilmann-Heimbach, Stefanie; Jamain, Stéphane; Hamilton, Steven P.; McElroy, Susan L.; Lucae, Susanne; Cichon, Sven; Schulze, Thomas G.; Hansen, Thomas; Werge, Thomas; Air, Tracy M.; Nimgaonkar, Vishwajit; Appadurai, Vivek; Cahn, Wiepke; Milaneschi, Yuri; Fanous, Ayman H.; Kendler, Kenneth S.; McQuillin, Andrew; Lewis, Cathryn M. (Journal article; Peer reviewed, 2019)
      Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric ...

    • GWAS-based pathway analysis differentiates between fluid and crystallized intelligence 

      Christoforou, Andrea; Espeseth, Thomas; Davis, G.; Fernandes, Carla P.D.; Giddaluru, Sudheer; Mattheisen, Manuel; Tenesa, A.; Harris, Sarah E.; Liewald, David C; Payton, Anthony; Ollier, W; Horan, M.; Pendleton, Neil; Haggarty, Paul; Djurovic, Srdjan; Herms, Stefan; Hoffman, P.; Cichon, Sven; Starr, John M; Lundervold, Astri; Reinvang, Ivar; Steen, Vidar Martin; Deary, Ian J; Le Hellard, Stephanie (Peer reviewed; Journal article, 2014-09)
      Cognitive abilities vary among people. About 40–50% of this variability is due to general intelligence (g), which reflects the positive correlation among individuals' scores on diverse cognitive ability tests. g is positively ...

    • Haemagglutination inhibition and virus microneutralisation serology assays: use of harmonised protocols and biological standards in seasonal influenza serology testing and their impact on inter-laboratory variation and assay correlation: A FLUCOP collaborative study 

      Waldock, Joanna; Remarque, Edmond J.; Zheng, Lingyi; Ho, Sammy; Hoschler, Katja; Neumann, Britta; Sediri-Schön, Hanna; Trombetta, Claudia M.; Montomoli, Emanuele; Marchi, Serena; Lapini, Giulia; Zhou, Fan; Jalloh, Sarah Larteley Lartey; Cox, Rebecca Jane; Facchini, Marzia; Castrucci, Maria Rita; Friel, Damien; Ollinger, Thierry; Caillet, Catherine; Music, Nedzad; Palladino, Giuseppe; Engelhardt, Othmar G. (Journal article; Peer reviewed, 2023)
      Introduction: The haemagglutination inhibition assay (HAI) and the virus microneutralisation assay (MN) are long-established methods for quantifying antibodies against influenza viruses. Despite their widespread use, both ...

    • Half of all hospitalised children treated with antibiotics for pneumonia did not fulfil radiological, microbiological or laboratory criteria 

      Selvåg, Maren Andrea Øvrum; Thaulow, Christian Magnus (Journal article; Peer reviewed, 2021)
      Aim Evaluating the management of paediatric pneumonia is important. We aimed to estimate the proportion of children receiving antibiotics for suspected community-acquired pneumonia (CAP) that were likely to have a bacterial ...

    • Half of children with recurrent or chronic wet cough before three years of age were symptom-free by age seven 

      Sørensen, Karen Galta; Mikalsen, Ingvild Bruun; Neven, Axel; Øymar, Knut (Journal article; Peer reviewed, 2020)
      Aim We aimed to study the natural course of recurrent episodic and chronic wet cough in preschool children, the proportion and age of resolution, and risk factors for persistent symptoms. Methods Parents of children ...

    • Handheld transabdominal ultrasound, after limited training, may confirm first trimester viable intrauterine pregnancy: a prospective cohort study 

      Pedersen, Judith Krossøy; Sira, Cecilie; Trovik, Jone (Journal article; Peer reviewed, 2021)
      Objectives Handheld point-of-care abdominal ultrasound (POCUS) may be used by primary care physicians while vaginal ultrasound is limited to use in specialist care. We aimed to compare abdominal handheld ultrasound to ...

    • Handling of hemolyzed serum samples in clinical chemistry laboratories: The Nordic hemolysis project 

      Gidske, Gro; Aakre, Kristin Moberg; Rustad, Pål; Sandberg, Sverre; Norling, Anna; Pelanti, Jonna; Henriksen, Gitte; Thorsteinsdóttir, Ingunn; Kristensen, Gunn Berit Berge (Peer reviewed; Journal article, 2019)
      Hemolysis of blood samples is a pre-analytical challenge that often leads to sample rejection in medical laboratories [1]. Hemolysis occurs when blood cells break down and the intracellular contents leak into the surrounding ...

    • Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium 

      Waerlop, Gwenn; Leroux-Roels, Geert; Lambe, Teresa; Bellamy, Duncan; Medaglini, Donata; Pettini, Elena; Cox, Rebecca Jane; Trieu, Mai Chi; Davies, Richard Allan; Bredholt, Geir; Montomoli, Emanuele; Gianchecchi, Elena; Clement, Frédéric (Journal article; Peer reviewed, 2022-09-08)
      Influenza continues to be the most important cause of viral respiratory disease, despite the availability of vaccines. Today’s evaluation of influenza vaccines mainly focuses on the quantitative and functional analyses of ...

    • Harmonization and qualification of intracellular cytokine staining to measure influenza-specific CD4+ T cell immunity within the FLUCOP consortium 

      Begue, Sarah; Waerlop, Gwenn; Salaun, Bruno; Janssens, Michel; Bellamy, Duncan; Cox, Rebecca Jane; Davies, Richard Allan; Gianchecchi, Elena; Medaglini, Donata; Montomoli, Emanuele; Pettini, Elena; Leroux-Roels, Geert; Clement, Frédéric; Pagnon, Anke (Journal article; Peer reviewed, 2022-10-20)
      Despite the knowledge that cell-mediated immunity (CMI) contributes to the reduction of severe influenza infection, transmission, and disease outcome, the correlates of protection for cell-mediated immunity remain still ...

    • Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy 

      Woan, Karrune V.; Kim, Hansol; Bjordahl, Ryan; Davis, Zachary B.; Gaidarova, Svetlana; Goulding, John; Hancock, Brian; Mahmood, Sajid; Abujarour, Ramzey; Wang, Hongbo; Tuininga, Katie; Zhang, Bin; Wu, Cheng-Ying; Kodal, Behiye; Khaw, Melissa; Bendzick, Laura; Rogers, Paul; Ge, Moyar Qing; Bonello, Greg; Meza, Miguel; Felices, Martin; Huffman, Janel; Dailey, Thomas; Lee, Tom T.; Walcheck, Bruce; Malmberg, Karl-Johan; Balzar, Bruce R.; Bryceson, Yenan; Valamehr, Bahram; Miller, Jeffrey S.; Cichocki, Frank (Journal article; Peer reviewed, 2021)
      Select subsets of immune effector cells have the greatest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and cell-based immunotherapy is hampered by limited effector-cell ...

    • HbA1c versus oral glucose tolerance test as a method to diagnose diabetes mellitus in vascular surgery patients 

      Hjellestad, Iren Drange; Astor, Marianne; Nilsen, Roy Miodini; Søfteland, Eirik; Jonung, Torbjørn (Peer reviewed; Journal article, 2013-05-25)
      Background: The diagnosis of diabetes mellitus (DM) is based on either fasting plasma glucose levels or an oral glucose tolerance test (OGTT). Recently, an HbA1c value of ≥48 mmol/mol (6.5%) has been included as an additional ...

    • The HDACi panobinostat shows growth inhibition both in vitro and in a bioluminescent orthotopic surgical xenograft model of ovarian cancer 

      Helland, Øystein; Popa, Mihaela Lucia; Bischof, Katharina; Gjertsen, Bjørn Tore; McCormack, Emmet; Bjørge, Line (Peer reviewed; Journal article, 2016-06-28)
      Background: In most epithelial ovarian carcinomas (EOC), epigenetic changes are evident, and overexpression of histone deacetylases (HDACs) represents an important manifestation. In this study, we wanted to evaluate the ...

    • Headache in systemic lupus erythematosus and primary Sjogren's syndrome 

      Tjensvoll, Anne Bolette (Doctoral thesis, 2016-11-09)
      Background Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which can affect multiple organs. The central nervous system (CNS) is frequently affected, and headache, especially migraine, is ...

    • Health Literacy and Risk Factors for Coronary Artery Disease (From the CONCARD PCI Study) 

      Brørs, Gunhild; Dalen, Håvard; Allore, Heather; Deaton, Christi; Fridlund, Bengt Gotthard Anton; Osborne, Richard H.; Palm, Pernille; Wentzel-Larsen, Tore; Norekvål, Tone Merete (Journal article; Peer reviewed, 2022)
      In the setting of established coronary artery disease (CAD), lower health literacy is associated with poor outcomes. The aim of this study was to determine whether health literacy at the index admission was associated with ...

    • Health professionals’ involvement of parents in decision-making in interprofessional practice at the hospital 

      Aarthun, Antje; Øymar, Knut; Akerjordet, Kristin (Peer reviewed; Journal article, 2020)
      Health professionals have the responsibility of involving parents in decision-making regarding children’s healthcare. This is to ensure that healthcare is customised to meet children’s and families’ needs and preferences. ...

    • Health-related quality of life in patients with advanced melanoma treated with ipilimumab: prognostic implications and changes during treatment 

      Aamdal, Elin; Skovlund, Eva; Jacobsen, Kari Dolven; Straume, Oddbjørn; Kersten, Christian; Herlofsen, Oluf; Karlsen, Jarle; Hussain, Israr; Amundsen, Anita; Dalhaug, Astrid; Nyakas, Marta Sølvi; Hagene, Kirsten Thorin; Holmsen, Kjersti; Aamdal, Steinar; Kaasa, Stein; Guren, Tormod Kyrre; Kyte, Jon A (Journal article; Peer reviewed, 2022)
      Background: We have previously reported that the safety and efficacy of ipilimumab in real-world patients with metastatic melanoma were comparable to clinical trials. Few studies have explored health-related quality of ...

    • Health-related quality of life, functional decline, and long-term mortality in older patients following hospitalisation due to COVID-19 

      Walle-Hansen, Marte; Ranhoff, Anette Hylen; Mellingsæter, Marte; Wang-Hansen, Marte Sofie; Myrstad, Marius (Journal article; Peer reviewed, 2021)
      Background Older people are particularly vulnerable to severe COVID-19. Little is known about long-term consequences of COVID-19 on health-related quality of life (HR-QoL) and functional status in older people, and the ...