Blar i Department of Clinical Science på tittel
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N-terminal pro-B-type natriuretic peptide as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest: A prospective observational study
(Journal article; Peer reviewed, 2020-08-24)Background Early risk stratification applying cardiac biomarkers may prove useful in sudden cardiac arrest patients. We investigated the prognostic utility of early-on levels of high sensitivity cardiac troponin-T (hs-cTnT), ... -
N-terminal pro-B-type natriuretic peptide level at longterm follow-up after atrial fibrillation ablation: A marker of reverse atrial remodeling and successful ablation
(Peer reviewed; Journal article, 2011-10-13)Aims: We investigated the relationship between arrhythmia burden, left atrial volume (LAV) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) at baseline and after long-term follow-up of atrial fibrillation (AF) ... -
Nausea and vomiting of pregnancy and hyperemesis gravidarum
(Peer reviewed; Journal article, 2019)Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as 70% of pregnant women. Although no consensus definition is available for hyperemesis gravidarum (HG), it is typically viewed as the severe ... -
Near-Infrared Fluorescent Imaging for Monitoring of Treatment Response in Endometrial Carcinoma Patient-Derived Xenograft Models.
(Journal article; Peer reviewed, 2020)Imaging of clinically relevant preclinical animal models is critical to the development of personalized therapeutic strategies for endometrial carcinoma. Although orthotopic patient-derived xenografts (PDXs) reflecting ... -
Need of education for dry powder inhaler storage and retention – a patient-reported survey
(Peer reviewed; Journal article, 2016-06-08)Background Dry powder inhalers (DPIs) are the most commonly used devices in asthma treatment in the Nordic countries. As new DPIs become available, patients are likely to be exposed to more than one type of device, with ... -
Neuropsychiatric symptoms in dementia: long-term course and neuropathology
(Doctoral thesis, 2019-06-14)Aim: Neuropsychiatric symptoms (NPS) such as anxiety, apathy, and psychosis are important manifestations of dementia that have a major impact on the patient’s quality of life, carer burden, and risk of institutionalisation. ... -
The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
(Peer reviewed; Journal article, 2014-10-04)Background: The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ... -
The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
(Peer reviewed; Journal article, 2014-10-04)Background. The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ... -
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation
(Journal article; Peer reviewed, 2020)Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ... -
A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses
(Peer reviewed; Journal article, 2019-10-30)Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ... -
New procedures for genetic testing and counselling of patients with breast or ovarian cancer
(Doctoral thesis, 2020-05-29)The aim of this PhD project was to evaluate alternative procedures for genetic testing and counselling of patients newly diagnosed with breast or ovarian cancer, in order to meet the expected increasing need of this health ... -
New therapeutic targets in human acute myeloid leukemia
(Doctoral thesis, 2012-03-16) -
Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease
(Peer reviewed; Journal article, 2013-11-06)Background: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was ... -
NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity
(Peer reviewed; Journal article, 2019-07-16)Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be ... -
No asymptomatic malaria parasitaemia found among 108 young children at one health facility in Dar es Salaam, Tanzania
(Peer reviewed; Journal article, 2013-11-14)Background: Asymptomatic malaria parasitaemia has been reported in areas with high malaria transmission. It may serve as a reservoir for continued transmission, and furthermore complicates diagnostics, as not all individuals ... -
No significant associations between breastfeeding practices and overweight in 8-year-old children
(Peer reviewed; Journal article, 2019)Aim: The aim was to examine if breastfeeding practices were associated with body mass index (BMI) and risk of overweight or obesity in third grade (8 years) of elementary school. Methods: In a regional cohort, we related ... -
Norwegian children and adolescents in blended families are at risk of larger one-year BMI increments
(Peer reviewed; Journal article, 2020)Aim: To study how sociodemographic factors and family structure associate with baseline BMI z‐scores (BMIz) and BMIz change in 767 Norwegian children aged 6‐15 years. Methods: Baseline BMIz and 1‐year BMIz increments in ... -
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
(Peer reviewed; Journal article, 2019)Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common ... -
Novel endoscopic and MRI-based methods for evaluating exocrine pancreatic function in pancreatitis and monogenic forms of diabetes
(Doctoral thesis; Peer reviewed, 2013-11-15)Background: Monogenic diabetes (Maturity onset diabetes in the young, MODY) are autosomal dominantly inherited diabetes syndromes characterized by diabetes due to beta cell dysfunction, with typical onset of diabetes before ... -
A novel fibrosis index comprising a non-cholesterol sterol accurately predicts HCV-related liver cirrhosis
(Peer reviewed; Journal article, 2014-04-03)Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. ...