Browsing Department of Clinical Science by Title

Now showing items 1528-1547 of 2390

    • N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity 

      Varland, Sylvia; Silva, Rui Duarte; Kjosås, Ine; Faustino, Alexandra; Bogaert, Annelies; Billmann, Maximilian; Boukhatmi, Hadi; Kellen, Barbara; Costanzo, Michael; Drazic, Adrian; Osberg, Camilla; Chan, Katherine; Zhang, Xiang; Tong, Amy Hin Yan; Andreazza, Simonetta; Lee, Juliette J.; Nedyalkova, Lyudmila; Ušaj, Matej; Whitworth, Alexander J.; Andrews, Brenda J.; Moffat, Jason; Myers, Chad L.; Gevaert, Kris; Boone, Charles; Martinho, Rui Gonçalo; Arnesen, Thomas (Journal article; Peer reviewed, 2023)
      Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between ...

    • N-terminal pro-B-type natriuretic peptide as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest: A prospective observational study 

      Aarsetøy, Reidun; Omland, Torbjørn; Røsjø, Helge; Strand, Heidi; Lindner, Thomas Werner; Aarsetøy, Hildegunn; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2020-08-24)
      Background Early risk stratification applying cardiac biomarkers may prove useful in sudden cardiac arrest patients. We investigated the prognostic utility of early-on levels of high sensitivity cardiac troponin-T (hs-cTnT), ...

    • N-terminal pro-B-type natriuretic peptide for prediction of ventricular arrhythmias: Data from the SMASH study 

      Sourour, Nur; Riveland, Egil Aarstad; Næsgaard, Patrycja; Kjekshus, Harald; Larsen, Alf Inge; Omland, Torbjørn; Røsjø, Helge Rørvik; Myhre, Peder Langeland (Journal article; Peer reviewed, 2023)
      Background Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations predict heart failure (HF) and mortality, but whether NT-proBNP predicts ventricular arrhythmias (VA) is not clear. Hypothesis We ...

    • N-terminal pro-B-type natriuretic peptide level at longterm follow-up after atrial fibrillation ablation: A marker of reverse atrial remodeling and successful ablation 

      Solheim, Eivind; Off, Morten Kristian; Hoff, Per Ivar; De Bortoli, Alessandro; Schuster, Peter; Ohm, Ole-Jørgen; Chen, Jian (Peer reviewed; Journal article, 2011-10-13)
      Aims: We investigated the relationship between arrhythmia burden, left atrial volume (LAV) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) at baseline and after long-term follow-up of atrial fibrillation (AF) ...

    • A national intercalated medical student research program–student perceptions, satisfaction, and factors associated with pursuing a PhD 

      Sandvei, Marie Søfteland; Jacobsen, Geir Wenberg; Stien, Marianne Heldal; Ræder, Helge; Munthe, Ludvig Andre; Skogen, Vegard (Journal article; Peer reviewed, 2022)
      Background: To counteract a decreasing number of physician-scientists, a national intercalated Medical Student Research Programme (MSRP) was launched in Norway in 2002. We aimed to assess whether the students’ favourable ...

    • Nationwide audit and feedback on implementation of antibiotic stewardship programmes in Norwegian hospitals 

      Skodvin, Brita; Høgli, June Utnes; Gravningen, Kirsten Midttun; Neteland, Marion Iren; Harthug, Stig; Akselsen, Per Espen (Journal article; Peer reviewed, 2021)
      Background Implementation of antibiotic stewardship programmes (ASPs) in hospitals is challenging and there is a knowledge gap on how to pursue this process efficiently. Objectives To evaluate whether audit and feedback ...

    • A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001–15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307 

      Fostervold, Aasmund; Hetland, Marit Andrea Klokkhammer; Bakksjø, Ragna-Johanne; Bernhoff, Eva; Holt, Kathryn E.; Samuelsen, Ørjan; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn; Wyres, Kelly L.; Löhr, Iren Høyland (Journal article; Peer reviewed, 2022)
      Objectives To use the nationwide Norwegian surveillance programme on resistant microbes in humans (NORM) to address longitudinal changes in the population structure of Klebsiella pneumoniae isolates from 2001–15, focusing ...

    • A nationwide school fruit and vegetable policy and childhood and adolescent overweight: A quasi-natural experimental study 

      Øvrebø, Bente; Stea, Tonje Holte; Bergh, Ingunn Holden; Bere, Elling Tufte; Suren, Pål; Magnus, Per Minor; Juliusson, Pétur Benedikt; Wills, Andrew Keith (Journal article; Peer reviewed, 2022)
      Background School free fruit and vegetable (FFV) policies are used to promote healthy dietary habits and tackle obesity; however, our understanding of their effects on weight outcomes is limited. We assess the effect of ...

    • The natural history of 21-hydroxylase autoantibodies in autoimmune Addison’s disease 

      Wolff, Anette Susanne Bøe; Breivik, Lars Ertesvåg; Hufthammer, Karl Ove; Grytaas, Marianne; Bratland, Eirik; Husebye, Eystein Sverre; Oftedal, Bergithe Eikeland (Journal article; Peer reviewed, 2021)
      Background: The most common cause of primary adrenal failure (Addison’s disease) in the Western world is autoimmunity characterized by autoantibodies against the steroidogenic enzyme 21-hydroxylase (CYP21A2, 21OH). Detection ...

    • Nausea and vomiting of pregnancy and hyperemesis gravidarum 

      Fejzo, Marlena Schoenberg; Trovik, Jone; Grooten, Iris J.; Sridharan, Kannan; Roseboom, Tessa J.; Vikanes, Åse Vigdis; Painter, Rebecca C.; Mullin, Patrick M. (Peer reviewed; Journal article, 2019)
      Nausea and vomiting of pregnancy (NVP) is a common condition that affects as many as 70% of pregnant women. Although no consensus definition is available for hyperemesis gravidarum (HG), it is typically viewed as the severe ...

    • Nausea Predicts Bacteremia in Immunocompetent Patients with Pneumococcal Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort 

      Fløystad, Hans Kristian; Holter, Jan Cato; Husebye, Einar; Siljan, William Ward; Berild, Dag; Holm, Are Martin; Heggelund, Lars (Journal article; Peer reviewed, 2023)
      Background: In pneumococcal community-acquired pneumonia (CAP), bacteremia is associated with increased mortality, but initial clinical severity scores frequently fail to identify bacteremic patients at risk. We have ...

    • Near-Infrared Fluorescent Imaging for Monitoring of Treatment Response in Endometrial Carcinoma Patient-Derived Xenograft Models. 

      Fonnes, Tina; Strand, Elin; Fasmer, Kristine Eldevik; Berg, Hege Fredriksen; Espedal, Heidi; Sortland, Kristina; Stefansson, Ingunn; Bjørge, Line; Haldorsen, Ingfrid S.; Krakstad, Camilla; Mc Cormack, Emmet (Journal article; Peer reviewed, 2020)
      Imaging of clinically relevant preclinical animal models is critical to the development of personalized therapeutic strategies for endometrial carcinoma. Although orthotopic patient-derived xenografts (PDXs) reflecting ...

    • Need of education for dry powder inhaler storage and retention – a patient-reported survey 

      Norderud Lærum, Birger; Telg, Gunilla; Stratelis, Georgios (Peer reviewed; Journal article, 2016-06-08)
      Background Dry powder inhalers (DPIs) are the most commonly used devices in asthma treatment in the Nordic countries. As new DPIs become available, patients are likely to be exposed to more than one type of device, with ...

    • Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice 

      Skarpengland, Tonje; Holm, Sverre; Scheffler, Katja; Gregersen, Ida; Dahl, Tuva Børresdatter; Suganthan, Rajikala; Segers, Filip; Østlie, Ingunn; Otten, Jeroen J.T.; Gomez, Luisa Fernanda Luna; Ketelhuth, Daniel F.J.; Lundberg, Anna M.; Neurauter, Christine Gran; Hildrestrand, Gunn Annette; Skjelland, Mona; Bjørndal, Bodil; Svardal, Asbjørn M.; Iversen, Per Ole; Hedin, Ulf; Nygård, Ståle; Olstad, Ole Kristoffer; Krohg-Sørensen, Kirsten; Slupphaug, Geir; Eide, Lars; Kusnierczyk, Anna; Folkersen, Lasse; Ueland, Thor; Berge, Rolf Kristian; Hansson, Göran K.; Biessen, Erik A.L.; Halvorsen, Bente; Bjørås, Magnar; Aukrust, Pål (Journal article; Peer reviewed, 2016)
      Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial ...

    • Neonatal outcomes associated with time from a high fetal blood lactate concentration to operative delivery 

      Berge, Magnus Bollum; Kessler, Jørg; Yli, Branislava Markovic; Staff, Anne Cathrine; Gunnes, Nina; Jacobsen, Anne Flem (Journal article; Peer reviewed, 2023)
      Introduction: Adjunctive technologies to cardiotocography intend to increase the specificity of the diagnosis of fetal hypoxia. If correctly diagnosed, time to delivery could affect neonatal outcome. In the present study, ...

    • Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren’s syndrome 

      Tjensvoll, Anne Bolette; Lauvsnes, Maria Boge; Zetterberg, Henrik; Kvaløy, Jan Terje; Kvivik, Ingeborg; Maroni, Stian; Greve, Ole Jacob; Beyer, Mona K.; Hirohata, Shunsei; Putterman, Chaim; Alves, Guido Werner; Harboe, Erna; Blennow, Kaj; Gøransson, Lasse; Omdal, Roald (Journal article; Peer reviewed, 2020)
      Background To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF ...

    • Neuroinflammation Associated With Inborn Errors of Immunity 

      Lindahl, Hannes; Bryceson, Yenan (Journal article; Peer reviewed, 2022)
      The advent of high-throughput sequencing has facilitated genotype-phenotype correlations in congenital diseases. This has provided molecular diagnosis and benefited patient management but has also revealed substantial ...

    • Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes 

      Fedotkina, Olena; Jain, Ruchi; Prasad, Rashmi B.; Luk, Andrea; García-Ramírez, Marta; Özgümüs, Türküler; Cherviakova, Liubov; Khalimon, Nadiya; Svietleisha, Tetiana; Buldenko, Tetiana; Kravchenko, Victor; Jain, Deepak; Vaag, Allan; Chan, Juliana; Khalangot, Mykola D.; Hernández, Cristina; Nilsson, Peter M.; Simo, Rafael; Artner, Isabella; Lyssenko, Valeriya (Journal article; Peer reviewed, 2022-05-05)
      Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are ...

    • Neuropsychiatric symptoms in dementia: long-term course and neuropathology 

      Vik-Mo, Audun Osland (Doctoral thesis, 2019-06-14)
      Aim: Neuropsychiatric symptoms (NPS) such as anxiety, apathy, and psychosis are important manifestations of dementia that have a major impact on the patient’s quality of life, carer burden, and risk of institutionalisation. ...

    • The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance 

      Jersin, Regine Åsen; Jonassen, Laura Roxana; Dankel, Simon N (Journal article; Peer reviewed, 2022)
      Obesity, insulin resistance and type 2 diabetes represent major global health challenges, and a better mechanistic understanding of the altered metabolism in these conditions may give improved treatment strategies. SLC7A10, ...