Browsing Department of Clinical Science by Title

Now showing items 1639-1658 of 2390

    • p53 protein biosignatures in acute myeloid leukemia 

      Ånensen, Nina (Doctoral thesis, 2006-03-10)
      p53 is a tumor suppressor protein often regarded as the guardian of the genome. It is a highly connected protein involved in many signaling processes in the cell. The inactivation of p53 through genetic mutations in TP53 ...

    • p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy 

      Haaland, Ingvild; Hjelle, Sigrun Margrethe; Reikvam, Håkon; Sulen, André; Ryningen, Anita; McCormack, Emmet; Bruserud, Øystein; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2021)
      p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic ...

    • Pain and pain tolerance in whiplash-associated disorders:A population-based study 

      Myrtveit, Solbjørg Makalani; Skogen, Jens Christoffer; Sivertsen, Børge; Steingrímsdóttir, Ólöf Anna; Stubhaug, Audun; Nielsen, Christopher Sivert (Peer reviewed; Journal article, 2015)
      Background: Pain is a cardinal symptom in individuals with whiplash-associated disorders (WAD). We aimed to compare pain characteristics between individuals with WAD and individuals reporting chronic pain from other causes, ...

    • Paradoxical sinus deceleration during dobutamine stress echocardiography: case series and review of the literature 

      Sulo, Enxhela; Davidsen, Einar Skulstad; Lønnebakken, Mai Tone; Bleie, Øyvind; Saeed, Sahrai (Journal article; Peer reviewed, 2022)
      Background: Dobutamine stress echocardiography is an established diagnostic modality for assessing myocardial ischaemia in patients with known or suspected coronary artery disease. Dobutamine infusion causes dose-dependent ...

    • Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit 

      Tandberg, Bente Silnes; Flacking, Renée; Markestad, Trond Jacob; Grundt, Hege; Moen, Atle (Peer reviewed; Journal article, 2019-11-05)
      Background Studies of parents’ psychological well-being in single-family rooms in neonatal intensive care units have shown conflicting results. Aims To compare emotional distress in the form of depression, anxiety, stress ...

    • Parental anxiety related to referral of childhood heart murmur; an observational/interventional study 

      Bårdsen, Tonje; Sørbye, Mari Hoven; Trønnes, Håvard; Greve, Gottfried; Berg, Ansgar (Peer reviewed; Journal article, 2015-11-21)
      Background: Detection of a heart murmur in healthy children is common, but may generate anxiety among parents. Many parents believe a heart murmur is a sign of heart disease, although the majority of heart murmurs are ...

    • Parental involvement in decision-making about their child's health care at the hospital 

      Aarthun, Antje; Øymar, Knut; Akerjordet, Kristin (Peer reviewed; Journal article, 2018-07-30)
      Aim: To explore parents’ experiences on parental involvement in decision‐making about their child’s health care at the hospital and to identify how health professionals can improve parental involvement. Design: An explorative ...

    • Parental smoking and risk of childhood-onset type 1 diabetes 

      Magnus, Maria Christine; Tapia, German; Olsen, Sjurdur Frodi; Granström, Charlotta; Mårild, Karl Staffan; Ueland, Per Magne; Midttun, Øivind; Svensson, Jannet; Johannesen, Jesper; Skrivarhaug, Torild; Joner, Geir; Njølstad, Pål Rasmus; Størdal, Ketil; Stene, Lars Christian Mørch (Peer reviewed; Journal article, 2018-11)
      Background: A few prospective studies suggest an association between maternal smoking during pregnancy and lower risk of type 1 diabetes. However, the role of unmeasured confounding and misclassification remains unclear. ...

    • Parents’ Attitudes toward Clinical Genetic Testing for Autism Spectrum Disorder—Data from a Norwegian Sample 

      Johannessen, Tor Jarle; Nærland, Terje; Hope, Sigrun; Torske, Tonje; Høyland, Anne Lise; Strohmaier, Jana; Heiberg, Arvid; Rietschel, Marcella; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2017-05-18)
      Clinical genetic testing (CGT) of children with autism spectrum disorder (ASD) may have positive and negative effects. Knowledge about parents’ attitudes is needed to ensure good involvement of caregivers, which is crucial ...

    • Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study 

      Knudsen, Gerd Toril Mørkve; Dharmage, Shyamali C.; Janson, Christer; Abramson, Michael J.; Benediktsdóttir, Bryndís; Malinovschi, Andrei; Skulstad, Svein Magne; Bertelsen, Randi Jacobsen; Real, Francisco Gomez; Schlünssen, Vivi; Jögi, Nils Oskar; Sánchez-Ramos, José Luis; Holm, Mathias; Garcia-Aymerich, Judith; Forsberg, Bertil; Svanes, Cecilie; Johannessen, Ane (Journal article; Peer reviewed, 2020)
      Emerging evidence suggests that parents’ preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index ...

    • PARP-inhibition reprograms macrophages toward an anti-tumor phenotype 

      Wang, Lin; Wang, Dan; Sonzogni, Olmo; Ke, Shizhong; Wang, Qi; Thavamani, Abhishek; Batalini, Felipe; Stopka, Sylwia A.; Regan, Michael S.; Vandal, Steven; Tian, Shengya; Pinto, Jocelin; Cyr, Andrew M.; Bret-Mounet, Vanessa C.; Baquer, Gerard; Eikesdal, Hans Petter; Yuan, Min; Asara, John M.; Heng, Yujing J.; Bai, Peter; Agar, Nathalie Y.R.; Wulf, Gerburg M. (Journal article; Peer reviewed, 2022)
      Poly(ADP)ribosylation inhibitors (PARPis) are toxic to cancer cells with homologous recombination (HR) deficiency but not to HR-proficient cells in the tumor microenvironment (TME), including tumor-associated macrophages ...

    • A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1 

      Oftedal, Bergithe Eikeland; Berger, Amund Holte; Bruserud, Øyvind; Goldfarb, Yael; Sulen, André; Breivik, Lars Ertesvåg; Hellesen, Richard Alexander Svortevik; Haffner-Krausz, Rebecca; Knappskog, Per Morten; Johansson, Stefan; Wolff, Anette Susanne Bøe; Bratland, Eirik; Abramson, Jakub; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      Autoimmune polyendocrine syndrome type 1 (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene. Most patients present with severe chronic mucocutaneous candidiasis and organ-specific autoimmunity from early ...

    • Participation in research bronchoscopy: a literature review 

      Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Bakke, Per S.; Eagan, Tomas Mikal; Grønseth, Rune (Peer reviewed; Journal article, 2016-02-03)
      Bronchoscopy is the preferred method for collecting biological samples from the lower airways of subjects in clinical research. However, ensuring participation in clinical research can be challenging when the research ...

    • Paternal and maternal birthweight and offspring risk of macrosomia at term gestations: A nationwide population study 

      Rasmussen, Svein; Carlsen, Ellen Øen; Linde, Lorentz; Morken, Nils-Halvdan; Håberg, Siri Eldevik; Ebbing, Cathrine (Journal article; Peer reviewed, 2023)
      Background There is a paucity of data on whether parents' macrosomia (birthweight ≥4500 g) status influences the risk of macrosomia in the offspring. The role of maternal overweight in the generational effect of macrosomia ...

    • Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes 

      Magnus, Maria Christine; Olsen, Sjurdur Frodi; Granström, Charlotta; Lund-Blix, Nicolai Andre; Svensson, Jannet; Johannesen, Jesper; Fraser, Abigail; Skrivarhaug, Torild; Joner, Geir; Njølstad, Pål Rasmus; Størdal, Ketil; Stene, Lars Christian Mørch (Peer reviewed; Journal article, 2018-02-05)
      Background Our objective was to examine the associations of parental body mass index (BMI) and maternal gestational weight gain with childhood-onset type 1 diabetes. Comparing the associations of maternal and paternal BMI ...

    • Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes 

      Magnus, Maria Christine; Olsen, Sjurdur Frodi; Granström, Charlotta; Lund-Blix, Nicolai Andre; Svensson, Jannet; Johannesen, Jesper; Fraser, Abigail; Skrivarhaug, Torild; Joner, Geir; Njølstad, Pål Rasmus; Størdal, Ketil; Stene, Lars Christian Mørch (Peer reviewed; Journal article, 2018-04)
      Background Our objective was to examine the associations of parental body mass index (BMI) and maternal gestational weight gain with childhood-onset type 1 diabetes. Comparing the associations of maternal and paternal BMI ...

    • Pathophysiological pathways in patients with heart failure and atrial fibrillation 

      Santema, Bernadet T.; Arita, Vicente Artola; Sama, Iziah E.; Kloosterman, Mariëlle; van den Berg, Maarten P.; Nienhuis, Hans L.A.; Van Gelder, Isabelle C.; van der Meer, Peter; Zannad, Faiez; Metra, Marco; Ter Maaten, Jozine M.; Cleland, John G.; Ng, Leong L.; Anker, Stefan D.; Lang, Chim C.; Samani, Nilesh J.; Dickstein, Kenneth; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Lam, Carolyn S.P.; Rienstra, Michiel; Voors, Adriaan A. (Journal article; Peer reviewed, 2022)
      Aims Atrial fibrillation (AF) and heart failure (HF) are two growing epidemics that frequently co-exist. We aimed to gain insights into the underlying pathophysiological pathways in HF patients with AF by comparing ...

    • Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure 

      Ceelen, Daan; Voors, Adriaan A.; Tromp, Jasper; van Veldhuisen, Dirk J.; Dickstein, Kenneth; de Boer, Rudolf A.; Lang, Chim C.; Anker, Stefan D.; Ng, Leong L.; Metra, Marco; Ponikowski, Piotr; Figarska, Sylwia M. (Journal article; Peer reviewed, 2022)
      Aims Elevated concentrations of growth differentiation factor 15 (GDF-15) in patients with heart failure (HF) have been consistently associated with worse clinical outcomes, but what disease mechanisms high GDF-15 ...

    • PathwayMatcher: proteoform-centric network construction enables fine-granularity multi-omics pathway mapping 

      Hernández Sánchez, Luis Francisco; Burger, Bram; Horro Marcos, Carlos; Fabregat, Antonio; Johansson, Stefan; Njølstad, Pål Rasmus; Barsnes, Harald; Hermjakob, Henning; Vaudel, Marc (Peer reviewed; Journal article, 2019-07-30)
      Background Mapping biomedical data to functional knowledge is an essential task in bioinformatics and can be achieved by querying identifiers (e.g., gene sets) in pathway knowledge bases. However, the isoform and ...

    • Pathway‑level mutation analysis in primary high‑grade serous ovarian cancer and matched brain metastases 

      Duchnowska, Renata; Supernat, Anna Maria; Pęksa, Rafał; Łukasiewicz, Marta; Stokowy, Tomasz; Ronen, Roy; Dutkowski, Janusz; Umińska, Monika; Iżycka-Świeszewska, Ewa; Kowalczyk, Anna; Och, Waldemar; Rucińska, Monika; Olszewski, Wojciech P.; Mandat, Tomasz; Jarosz, Bożena; Bieńkowski, Michał; Biernat, Wojciech; Jassem, Jacek (Journal article; Peer reviewed, 2022)
      Brain metastases (BMs) in ovarian cancer (OC) are a rare event. BMs occur most frequently in high-grade serous (HGS) OC. The molecular features of BMs in HGSOC are poorly understood. We performed a whole-exome sequencing ...