Blar i Department of Clinical Science på utgivelsesdato
Viser treff 21-40 av 2390
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Nuclear Receptor Coregulators Role of Protein-Protein Interactions and cAMP/PKA Signaling
(Doctoral thesis, 2007-02-02) -
Inflammatory biomarkers with focus on Calprotectin (S100A8/S100A9) and S100A12 (EN-RAGE) : method development and application in acute radiation proctitis and rheumatoid arthritis patients
(Doctoral thesis, 2007-02-02)Assessments of diseases are usually performed by a combination of clinical symptoms, signs and objective measurements. Biochemical markers of inflammation are important in evaluation of treatment of acute and chronic ... -
The effects of smoking cessation intervention in patients with coronary heart disease : a randomised, controlled trial
(Doctoral thesis, 2007-02-09)Background: Smoking cessation is the most important action to reduce mortality after a coronary event. Largely, it has previously been unknown whether a smoking cessation program applicable in an ordinary clinical setting ... -
Immunological aspects of acute myelogenous leukemia
(Doctoral thesis, 2007-02-23)Acute myelogenous leukemia (AML) is an aggressive malignancy characterized by accumulation of immature myeloid cells in the bone marrow. The overall disease-free survival is less than 50% even for the younger patients who ... -
Early outcome and restenosis after coronary stenting : intervention with stent-coatings, antioxidants and radiation
(Doctoral thesis, 2007-03-16) -
Comprehensive Analysis of Exported Proteins from Mycobacterium tuberculosis H37Rv
(Proteomics, Peer reviewed; Journal article, 2007-04-21)Proteins secreted by Mycobacterium tuberculosis play an essential role in the pathogenesis of tuberculosis. The culture filtrates of M. tuberculosis H37Rv made by Sadamu Nagai (Japan), are considerably enriched for secreted ... -
Identification of diarrheagenic Escherichia coli isolated from infants and children in Dar es Salaam, Tanzania
(Peer reviewed; Journal article, 2007-08-09)Background: Relatively few studies have been done in Tanzania to detect and classify diarrheagenic Escherichia coli (DEC) strains among children with diarrhea. This study aimed at investigating DEC among children in Dar ... -
Flt3 receptor tyrosine kinase in AML and its modulation of the p53/Hdm2/Bcl-2 pathway
(Doctoral thesis, 2007-09-06)Acute myeloid leukemia (AML) is an aggressive disease with a poor overall survival rate. The most frequent mutations associated with AML are internal tandem duplications (ITD) in the juxtamembrane region of the receptor ... -
Secreted proteins and surface markers on tubercle bacilli
(Doctoral thesis, 2007-12-12)Tuberculosis caused by Mycobacterium tuberculosis (M. tuberculosis) is the major cause of mortality and morbidity of over two million people each year. Mapping of proteins exported by the pathogen to the extracellular ... -
Calprotectin (S100A8/A9) and S100A12 in inflammatory arthritis : clinical and epidemiological studies of rheumatoid and psoriatic arthritis
(Doctoral thesis, 2007-12-14)Rheumatoid- and psoriatic arthritis (RA and PsA) are the two most prevalent inflammatory joint diseases in Caucasian. Different biomarkers in peripheral blood may contribute in the diagnostic and prognostic process, as ... -
Adjuvant treatment: the contribution of expression microarrays
(Peer reviewed; Journal article, 2007-12-20) -
Prevalence of enteropathogenic viruses and molecular characterization of group A rotavirus among children with diarrhea in Dar es Salaam Tanzania
(Peer reviewed; Journal article, 2007-12-27)Background Different groups of viruses have been shown to be responsible for acute diarrhea among children during their first few years of life. Epidemiological knowledge of viral agents is critical for the development of ... -
Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study
(Peer reviewed; Journal article, 2007-12-27)Background: To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, - M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs). Methods: A total of ... -
Fatty acids in synovial fluid (SF) and inflammatory markers in SF and serum from patients with inflammatory joint diseases. With focus on correlation of n-6 and n-3 polyunsaturated fatty acids to SF cytokines interleukin (IL)-6 and IL-12 and serum Creactive protein
(Master thesis, 2008)Little attention has been brought on the lipid content and fatty acid composition directly in synovial fluid (SF) from joints of patients with inflammatory joint diseases. Studies indicate that excessive SF lipids and fatty ... -
Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques
(Peer reviewed; Journal article, 2008-01-26)Background: The reported diagnostic yield from bronchoscopies in patients with lung cancer varies greatly. The optimal combination of sampling techniques has not been finally established. The objectives of this study were ... -
Stimulated monocyte IL-6 secretion predicts survival of patients with head and neck squamous cell carcinoma
(Peer reviewed; Journal article, 2008-01-30)Background This study was performed in order to determine whether monocyte in vitro function is associated with presence, stage and prognosis of head and neck squamous cell carcinoma (HNSCC) disease. Methods Prospective ... -
Herpesviral interactomics. Intraviral and virus-host protein-protein interaction network from different species of herpesviruses
(Doctoral thesis, 2008-02-01) -
Kjernereseptorar og endokrinforstyrrande stoff: Ligandaktiveringsstudiar av human Pregnan X Reseptor (hPXR) og human Østrogen Reseptor alfa (hERalfa) med luciferase transfeksjonsassay
(Master thesis, 2008-05-28)Samandrag Pregnan X Reseptor (PXR) er ein kjernereseptor som ved aktivering kan indusere transkripsjon av CYP3A4 enzym. Desse enzyma er involvert i metabolisme av mange sambindingar som til dømes legemiddel. PXR vert ... -
A rat modell to assess interventions to reduce cardiotoxicity of anthracyclines Does pre-treatment with morphine reduce the cardiotoxicity of doxorubicin?
(Master thesis, 2008-05-30)A rat model to assess interventions to reduce cardiotoxicity of anthracyclines is of interest. The model should be able to induce significant myocardial damage rapidly but at the same time allow for measurement of protective ... -
Glucocorticoid pharmacogenetics in Addison's disease - The role of the immunophilin FK506-binding protein (FKBP51) for glucocorticoid sensitivity
(Master thesis, 2008-05-31)There is great variation in the inter-individual sensitivity to glucocorticoids. The immunophilin FK506 binding protein (FKBP51) confers short-loop negative feedback inhibition of the glucocorticoid signalling pathway. ...