• Association of adult lung function with accelerated biological aging 

      Rezwan, Faizal I; Imboden, Medea; Amaral, André F.S.; Wielscher, Matthias; Jeong, Ayoung; Triebner, Kai; Gomez Real, Francisco; Jarvelin, Marjo-Riitta; Jarvis, Deborah; Probst-Hensch, Nicole M; Holloway, John W (Journal article; Peer reviewed, 2020)
      Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan ...
    • Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status 

      Nerpin, Elisabet; Ferreira, Diogenes Seraphim; Weyler, Joost; Schlunnsen, Vivi; Jogi, Rain; Raherison, Chantal; Gislasson, Thorainn; Demoly, Pascal; Heinrich, Joachim; Nowak, Dennis; Corsico, Angelo; Accordini, Simone; Marcon, Alessandro; Squillacioti, Giulia; Olivieri, Mario; Nielsen, Rune; Johannessen, Ane; Real, Francisco Gomez; Garcia-Aymerich, Judith; Urrutia, Isabel; Pereira-Vega, Antonio; Gullón, José-Antonio; Olin, Anna-Carin; Forsberg, Bertil; Emilsson, Össur Ingi; Pin, Isabelle; Jarvis, Deborah; Janson, Christer; Malinovschi, Andrei (Journal article; Peer reviewed, 2021)
      Background Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and ...
    • Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels 

      Triebner, Kai; Johannessen, Ane; Svanes, Cecilie; Leynaert, Bénédicte; Benediktsdóttir, Bryndís; Demoly, Pascal; Dharmage, Shyamali C.; Franklin, Karl A.; Heinrich, Joachim; Holm, Mathias; Jarvis, Deborah; Lindberg, Eva; Moratalla, Jesús Martínez; Agirre, Nerea Muniozguren; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Skulstad, Svein Magne; Hustad, Steinar; Rodríguez, Francisco J.; Gomez Real, Francisco (Journal article; Peer reviewed, 2020)
      Objective Most women live to experience menopause and will spend 4–8 years transitioning from fertile age to full menstrual stop. Biologically, reproductive ageing is a continuous process, but by convention, it is defined ...
    • Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III 

      Nerpin, Elisabet; Olivieri, Mario; Gislason, Thorainn; Olin, Anna C.; Nielsen, Rune; Johannessen, Ane; Ferreira, Diogenes S.; Marcon, Alessandro; Cazzoletti, Lucia; Accordini, Simone; Pin, Isabelle; Corsico, Angelo; Demoly, Pascal; Weyler, Joost; Nowak, Dennis; Jõgi, Rain; Forsberg, Bertil; Zock, Jan P.; Sigsgaard, Torben; Heinric, Joachim; Bono, Roberto; Leynaert, Bénédicte; Jarvis, Deborah; Janson, Christer; Malinovschi, Anderi (Peer reviewed; Journal article, 2019)
      Introduction: The fractional exhaled nitric oxide (FENO ) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors ...
    • Epigenome-wide association of father's smoking with offspring DNA methylation: a hypothesis-generating study 

      Knudsen, Gerd Toril Mørkve; Rezwan, FI; Johannessen, Ane; Skulstad, Svein Magne; Bertelsen, Randi Jacobsen; Gomez Real, Francisco; Krauss-Etschmann, Susanne; Patil, Viswanath; Jarvis, Deborah; Arshad, SH; Holloway, John W; Svanes, Cecilie (Peer reviewed; Journal article, 2019)
      Epidemiological studies suggest that father’s smoking might influence their future children’s health, but few studies have addressed whether paternal line effects might be related to altered DNA methylation patterns in the ...
    • European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation 

      Budu-Aggrey, Ashley; Kilanowski, Anna; Sobczyk, Maria K.; Shringarpure, Suyash S.; Mitchell, Ruth; Reis, Kadri; Reigo, Anu; Mägi, Reedik; Nelis, Mari; Tanaka, Nao; Brumpton, Ben Michael; Thomas, Laurent Francois; Sole-Navais, Pol; Flatley, Christopher; Espuela-Ortiz, Antonio; Herrera-Luis, Esther; Lominchar, Jesus V. T.; Bork-Jensen, Jette; Marenholz, Ingo; Arnau-Soler, Aleix; Jeong, Ayoung; Fawcett, Katherine A.; Baurecht, Hansjorg; Rodriguez, Elke; Alves, Alexessander Couto; Kumar, Ashish; Sleiman, Patrick M.; Chang, Xiao; Medina-Gomez, Carolina; Hu, Chen; Xu, Cheng-jian; Qi, Cancan; El-Heis, Sarah; Titcombe, Philip; Antoun, Elie; Fadista, João; Wang, Carol A.; Thiering, Elisabeth; Wu, Baojun; Kress, Sara; Kothalawala, Dilini M.; Kadalayil, Latha; Duan, Jiasong; Zhang, Hongmei; Hadebe, Sabelo; Hoffmann, Thomas; Jorgenson, Eric; Choquet, Hélène; Risch, Neil; Njølstad, Pål Rasmus; Andreassen, Ole; Johansson, Stefan; Almqvist, Catarina; Gong, Tong; Ullemar, Vilhelmina; Karlsson, Robert; Magnusson, Patrik K. E.; Szwajda, Agnieszka; Burchard, Esteban G.; Thyssen, Jacob P.; Hansen, Torben; Kårhus, Line L.; Dantoft, Thomas M.; Jeanrenaud, Alexander C.S.N.; Ghauri, Ahla; Arnold, Andreas; Homuth, Georg; Lau, Susanne; Nöthen, Markus M.; Hübner, Norbert; Imboden, Medea; Visconti, Alessia; Falchi, Mario; Bataille, Veronique; Hysi, Pirro; Ballardini, Natalia; Boomsma, Dorret I.; Hottenga, Jouke J.; Müller-Nurasyid, Martina; Ahluwalia, Tarunveer S.; Stokholm, Jakob; Chawes, Bo; Schoos, Ann-Marie M.; Esplugues, Ana; Bustamante, Mariona; Raby, Benjamin; Arshad, Syed; German, Chris; Esko, Tõnu; Milani, Lili A.; Metspalu, Andres; Terao, Chikashi; Abuabara, Katrina; Løset, Mari; Hveem, Kristian; Jacobsson, Bo; Pino-Yanes, Maria; Strachan, David P.; Grarup, Niels; Linneberg, Allan; Lee, Young-Ae; Probst-Hensch, Nicole; Weidinger, Stephan; Jarvelin, Marjo-Riitta; Melén, Erik; Hakonarson, Hakon; Irvine, Alan D.; Jarvis, Deborah; Nijsten, Tamar; Duijts, Liesbeth; Vonk, Judith M.; Koppelmann, Gerard H.; Godfrey, Keith M.; Barton, Sheila J.; Feenstra, Bjarke; Pennell, Craig E.; Sly, Peter D.; Holt, Patrick G.; Williams, L. Keoki; Bisgaard, Hans; Bønnelykke, Klaus; Curtin, John; Simpson, Angela; Murray, Clare; Schikowski, Tamara; Bunyavanich, Supinda; Weiss, Scott T.; Holloway, John W.; Min, Josine L.; Brown, Sara J.; Standl, Marie; Paternoster, Lavinia (Journal article; Peer reviewed, 2023)
      Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery ...
    • Latitude, Birth Date, and Allergy 

      Wjst, Matthias; Dharmage, Shyamali; André, Elisabeth; Norbäck, Dan; Raherison, Chantal; Villani, Simona; Manfreda, Jure; Sunyer, Jordi; Jarvis, Deborah; Burney, Peter; Svanes, Cecilie (PLoS Medicine 2(10): e294, Peer reviewed; Journal article, 2005-10-04)
      Background: The space and time distribution of risk factors for allergic diseases may provide insights into disease mechanisms. Allergy is believed to vary by month of birth, but multinational studies taking into account ...
    • Menopause as a predictor of new-onset asthma 

      Triebner, Kai; Johannessen, Ane; Puggini, Luca; Benediktsdottir, Bryndis; Bertelsen, Randi Jacobsen; Bifulco, Ersilia; Dharmage, Shyamali C.; Franklin, Karl A.; Gislason, Þórarinn; Holm, Mathias; Jarvis, Deborah; Leynaert, Bénédicte; Lindberg, Eva; Macsali, Ferenc; Malinovschi, Andrej; Norbäck, Dan; Omenaas, Ernst; Rodriguez, Francisco J; Saure, Eirunn Waatevik; Schlünssen, Vivi; Sigsgaard, Torben; Skorge, Trude Duelien; Wieslander, Gunilla; Zemp, Elisabeth; Svanes, Cecilie; Hustad, Simon Steinar; Gomez Real, Francisco (Peer reviewed; Journal article, 2015-01)
      Background: There is limited and conflicting evidence on the effect of menopause on asthma. Objectives: We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal ...
    • Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III 

      Janson, Christer; Accordini, Simone; Cazzoletti, Lucia; Cerveri, Isa; Chanoine, S; Corsico, Angelo; Ferreira, D.S.; Garcia-Aymerich, Judith; Gislason, Thorarinn; Nielsen, Rune; Johannessen, Ane; Jõgi, Rain; Malinovschi, Andrei; Moratalla, Jesús Martínez; Marcon, Alessandro; Pin, Isabelle; Quint, JK; Siroux, Valerie; Almar, Enrique; Bellisario, Valeria; Franklin, Karl A.; Gullon, JA; Holm, Mathias; Heinrich, Joachim; Nowak, Dennis; Sánchez-Ramos, José Luis; Weyler, Joost; Jarvis, Deborah (Peer reviewed; Journal article, 2019)
      Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with ...
    • Residential greenspace and lung function decline over 20 years in a prospective cohort: The ECRHS study 

      Markevych, Iana; Zhao, Tianyu; Fuertes, Elaine; Marcon, Alessandro; Dadvand, Payam; Vienneau, Danielle; Garcia Aymerich, Judith; Nowak, Dennis; de Hoogh, Kees; Jarvis, Deborah; Abramson, Michael J.; Accordini, Simone; Amaral, Andre FS; Bentouhami, Hayat; Bertelsen, Randi Jacobsen; Boudier, Anne; Bono, Roberto; Bowatte, Gayan; Casas, Lidia; Dharmage, Shyamali C; Forsberg, Bertil; Gislason, Thorarinn; Gnesi, Marco; Holm, Mathias; Jacquemin, Benedicte; Janson, Christer; Jogi, Rain; Johannessen, Ane; Keidel, Dirk; Leynaert, Benedicte; Maldonado Perez, José Antonio; Marchetti, Pierpaolo; Migliore, Enrica; Martínez-Moratalla, Jesús; Orru, Hans; Pin, Isabelle; Potts, James; Probst-Hensch, Nicole; Ranzi, Andrea; Sánchez-Ramos, José Luis; Siroux, Valerie; Soussan, David; Sunyer, Jordi; Urrutia Landa, Isabel; Villani, Simona; Heinrich, Joachim (Journal article; Peer reviewed, 2023)
      Background: The few studies that have examined associations between greenspace and lung function in adulthood have yielded conflicting results and none have examined whether the rate of lung function decline is ...