• A MicroRNA Linking Human Positive Selection and Metabolic Disorders 

      Wang, Lifeng; Sinnott-Armstrong, Nicholas A; Wagschal, Alexandre; Wark, Abigail R.; Camporez, Joao-Paulo; Perry, Rachel J.; Ji, Fei; Sohn, Yoojin; Oh, Justin; Wu, Su; Chery, Jessica; Moud, Bahareh Nemati; Saadat, Alham; Dankel, Simon N; Mellgren, Gunnar; Tallapragada, Divya Sri Priyanka; Strobel, Sophie Madlen; Lee, Mi-Jeong; Tewhey, Ryan; Sabeti, Pardis C.; Schaefer, Anne; Petri, Andreas; Kauppinen, Sakari; Chung, Raymond T.; Soukas, Alexander; Avruch, Joseph; Fried, Susan K.; Hauner, Hans; Sadreyev, Ruslan I.; Shulman, Gerald I.; Claussnitzer, Melina; Näär, Anders M. (Journal article; Peer reviewed, 2020)
      Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also ...
    • Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance 

      Jersin, Regine Å.; Tallapragada, Divya Sri Priyanka; Madsen, André; Skartveit, Linn; Fjære, Even; McCann, Adrian; Dyer, Laurence; Willems, Aron; Bjune, Jan-Inge; Bjune, Mona S.; Våge, Villy; Nielsen, Hans Jørgen; Thorsen, Håvard Luong; Nedrebø, Bjørn Gunnar; Busch, Christian; Steen, Vidar M.; Blüher, Matthias; Jacobson, Peter; Svensson, Per-Arne; Fernø, Johan; Rydén, Mikael; Arner, Peter; Nygård, Ottar; Claussnitzer, Melina; Ellingsen, Ståle; Madsen, Lise; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2021)
      Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ...