Blar i Department of Clinical Science på tidsskrift "iScience"

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    • Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans 

      Nepal, Chirag; Taranta, Andrzej; Hadzhiev, Yavor; Pundhir, Sachin; Mydel, Piotr Mateusz; Lenhard, Boris; Müller, Ferenc; Andersen, Jesper B. (Journal article; Peer reviewed, 2020-04)
      HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient ...

    • Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producing Klebsiella pneumoniae infections 

      Wannigama, Dhammika Leshan; Sithu Shein, Aye Mya; Hurst, Cameron; Monk, Peter N.; Hongsing, Parichart; Phattharapornjaroen, Phatthranit; Fox Ditcham, William Graham; Ounjai, Puey; Saethang, Thammakorn; Chantaravisoot, Naphat; Wapeesittipan, Pattama; Luk-in, Sirirat; Sae-Joo, Sasipen; Nilgate, Sumanee; Rirerm, Ubolrat; Tanasatitchai, Chanikan; Kueakulpattana, Naris; Laowansiri, Matchima; Liao, Tingting; Kupwiwat, Rosalyn; Rojanathanes, Rojrit; Ngamwongsatit, Natharin; Tungsanga, Somkanya; Leelahavanichkul, Asada; Devanga Ragupathi, Naveen Kumar; Badavath, Vishnu Nayak; Hosseini Rad, S.M. Ali; Kanjanabuch, Talerngsak; Hirankarn, Nattiya; Storer, Robin James; Cui, Longzhu; Amarasiri, Mohan; Ishikawa, Hitoshi; Higgins, Paul G.; Stick, Stephen M.; Kicic, Anthony; Chatsuwan, Tanittha; Abe, Shuichi (Journal article; Peer reviewed, 2023)
      Developing an effective therapy to overcome carbapenemase-positive Klebsiella pneumoniae (CPKp) is an important therapeutic challenge that must be addressed urgently. Here, we explored a Ca-EDTA combination with aztreonam ...

    • DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance 

      Zhang, Juan; Terán, Graciela; Popa, Mihaela-Lucia; Madapura, Harsha; Ladds, Marcus J.G.W.; Lianoudaki, Danai; Grünler, Jacob; Arsenian-Henriksson, Marie; McCormack, Emmet; Rottenberg, Martin Enrique; Catrina, Sergiu-Bogdan; Laín, Sonia; Darekar, Suhas (Journal article; Peer reviewed, 2021)
      Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer ...

    • Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes 

      Oftedal, Bergithe Eikeland; Assing, Kristian; Baris, Safa; Safgren, Stephanie L.; Johansen, Isik S.; Jakobsen, Marianne Antonius; Babovic-Vuksanovic, Dusica; Agre, Katherine; Klee, Eric W.; Majcic, Emina; Ferré, Elise M.N.; Schmitt, Monica M.; DiMaggio, Tom; Rosen, Lindsey B.; Rahman, Muhammad; Chrysis, Dionisios; Giannakopoulos, Aristeidis; Garcia, Maria Tallon; González-Granado, Luis Ignacio; Stanley, Katherine; Galant-Swafford, Jessica; Suwannarat, Pim; Meyts, Isabelle; Lionakis, Michail S.; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disease characterized by severe and childhood onset organ-specific autoimmunity caused by mutations in the autoimmune regulator (AIRE) gene. More ...

    • HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived induced pluripotent stem cells 

      Ng, Natasha Hui Jin; Jasmen, Joanita Binte; Lim, Chang Siang; Lau, Hwee Hui; Krishnan, Vidhya Gomathi; Kadiwala, Juned; Kulkarni, Rohit N.; Ræder, Helge; Vallier, Ludovic; Hoon, Shawn; Teo, Adrian Kee Keong (Peer reviewed; Journal article, 2019-06-28)
      Maturity-onset diabetes of the young 1 (MODY1) is a monogenic diabetes condition caused by heterozygous HNF4A mutations. We investigate how HNF4A haploinsufficiency from a MODY1/HNF4A mutation influences the development ...

    • Vaccination prevents severe COVID-19 outcome in patients with neutralizing type 1 interferon autoantibodies 

      Wolff, Anette Susanne Bøe; Hansen, Lena; Grytaas, Marianne Aardal; Oftedal, Bergithe Eikeland; Breivik, Lars Ertesvåg; Zhou, Fan; Hufthammer, Karl Ove; Sjøgren, Thea; Olofsson, Jan Stefan; Trieu, Mai Chi; Meager, Anthony; Jørgensen, Anders Palmstrøm; Lima, Kari; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox Brokstad, Rebecca Jane; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      A hallmark of patients with autoimmune polyendocrine syndrome type 1 (APS-1) is serological neutralizing autoantibodies against type 1 interferons (IFN-I). The presence of these antibodies has been associated with severe ...