dc.contributor.author | Kmiecik, Justyna | en_US |
dc.contributor.author | Poli, Aurélie | en_US |
dc.contributor.author | Brons, Nicolaas H.C. | en_US |
dc.contributor.author | Waha, Andreas | en_US |
dc.contributor.author | Eide, Geir Egil | en_US |
dc.contributor.author | Enger, Per Øyvind | en_US |
dc.contributor.author | Zimmer, Jacques | en_US |
dc.contributor.author | Chekenya, Martha | en_US |
dc.date.accessioned | 2014-01-14T09:39:52Z | |
dc.date.available | 2014-01-14T09:39:52Z | |
dc.date.issued | 2013-11-15 | eng |
dc.Published | Journal of Neuroimmunology 264 (1-2): 71–83 | eng |
dc.identifier.issn | 0165-5728 | |
dc.identifier.uri | https://hdl.handle.net/1956/7668 | |
dc.description.abstract | We characterized GBM patients' tumor and systemic immune contexture with aim to reveal themechanisms of immunological escape, their impact on patient outcome, and identify targets for immunotherapy. Increased CD3+ T-cell infiltration was associated with prolonged survival independent of age, MGMT promoter methylation and post-operative treatment that implies potential for immunotherapy for GBM. Several mechanisms of escape were identified: within the tumor microenvironment: induced CD8+CD28−Foxp3+ Tregs that may tolerize antigen presenting cells, elevated CD73 and CD39 ectonucleotidases that suppress T-cell function, and at the systemic level: elevated IL-10 levels in serum, diminished helper T-cell counts, and upregulated inhibitory CTLA-4. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Elsevier | eng |
dc.relation.ispartof | <a href="http://hdl.handle.net/1956/7670" target="blank">Immunological mechanisms of tumour progression. The rationale for natural killer cell based immunotherapy for glioblastoma</a> | eng |
dc.relation.ispartof | <a href="http://hdl.handle.net/1956/7866" target="blank">Targeting the anti-inflammatory interplay promoting glioblastoma progression with combined natural killer cells and mab9.2.27 against NG2/CSPG4</a> | eng |
dc.rights | Attribution-NonCommercial-NoDerivs CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0 | eng |
dc.subject | Tumor infiltrating cells | eng |
dc.subject | Regulatory T cells | eng |
dc.subject | Antigen presenting cells | eng |
dc.title | Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2013 The Authors | |
dc.identifier.doi | https://doi.org/10.1016/j.jneuroim.2013.08.013 | |
dc.identifier.cristin | 1095798 | |
dc.source.journal | Journal of Neuroimmunology | |
dc.source.40 | 264 | |
dc.source.14 | 1-2 | |
dc.source.pagenumber | 71-83 | |