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dc.contributor.authorKmiecik, Justynaen_US
dc.contributor.authorPoli, Aurélieen_US
dc.contributor.authorBrons, Nicolaas H.C.en_US
dc.contributor.authorWaha, Andreasen_US
dc.contributor.authorEide, Geir Egilen_US
dc.contributor.authorEnger, Per Øyvinden_US
dc.contributor.authorZimmer, Jacquesen_US
dc.contributor.authorChekenya, Marthaen_US
dc.PublishedJournal of Neuroimmunology 264 (1-2): 71–83eng
dc.description.abstractWe characterized GBM patients' tumor and systemic immune contexture with aim to reveal themechanisms of immunological escape, their impact on patient outcome, and identify targets for immunotherapy. Increased CD3+ T-cell infiltration was associated with prolonged survival independent of age, MGMT promoter methylation and post-operative treatment that implies potential for immunotherapy for GBM. Several mechanisms of escape were identified: within the tumor microenvironment: induced CD8+CD28−Foxp3+ Tregs that may tolerize antigen presenting cells, elevated CD73 and CD39 ectonucleotidases that suppress T-cell function, and at the systemic level: elevated IL-10 levels in serum, diminished helper T-cell counts, and upregulated inhibitory CTLA-4.en_US
dc.relation.ispartof<a href="" target="blank">Immunological mechanisms of tumour progression. The rationale for natural killer cell based immunotherapy for glioblastoma</a>eng
dc.relation.ispartof<a href="" target="blank">Targeting the anti-inflammatory interplay promoting glioblastoma progression with combined natural killer cells and mab9.2.27 against NG2/CSPG4</a>eng
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.subjectTumor infiltrating cellseng
dc.subjectRegulatory T cellseng
dc.subjectAntigen presenting cellseng
dc.titleElevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic levelen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2013 The Authors
dc.source.journalJournal of Neuroimmunology

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