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dc.contributor.authorPortales-Casamar, Elodieeng
dc.contributor.authorThongjuea, Supateng
dc.contributor.authorKwon, Andrew T.eng
dc.contributor.authorArenillas, Davideng
dc.contributor.authorZhao, Xiaobeieng
dc.contributor.authorValen, Eivindeng
dc.contributor.authorYusuf, Dimaseng
dc.contributor.authorLenhard, Boriseng
dc.contributor.authorWasserman, Wyeth W.eng
dc.contributor.authorSandelin, Albineng
dc.description.abstractJASPAR ( is the leading open-access database of matrix profiles describing the DNA-binding patterns of transcription factors (TFs) and other proteins interacting with DNA in a sequence-specific manner. Its fourth major release is the largest expansion of the core database to date: the database now holds 457 non-redundant, curated profiles. The new entries include the first batch of profiles derived from ChIP-seq and ChIPchip whole-genome binding experiments, and 177 yeast TF binding profiles. The introduction of a yeast division brings the convenience of JASPAR to an active research community. As binding models are refined by newer data, the JASPAR database now uses versioning of matrices: in this release, 12% of the older models were updated to improved versions. Classification of TF families has been improved by adopting a new DNA-binding domain nomenclature. A curated catalog of mammalian TFs is provided, extending the use of the JASPAR profiles to additional TFs belonging to the same structural family. The changes in the database set the system ready for more rapid acquisition of new high-throughput data sources. Additionally, three new special collections provide matrix profile data produced by recent alternative high-throughput approaches.en_US
dc.publisherOxford University Pressen_US
dc.relation.ispartof<a href="" target="blank">Analysis of transcription factor complexes and their associated chromatin interactions during erythropoiesis</a>en_US
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.titleJASPAR 2010: the greatly expanded open-access database of transcription factor binding profilesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2009. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.source.journalNucleic Acids Research

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