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dc.contributor.authorKlingen, Tor Audunen_US
dc.contributor.authorChen, Yingen_US
dc.contributor.authorSuhrke, Pålen_US
dc.contributor.authorStefansson, Ingunnen_US
dc.contributor.authorGundersen, Marian D.en_US
dc.contributor.authorAkslen, Lars A.en_US
dc.date.accessioned2014-05-23T08:25:33Z
dc.date.available2014-05-23T08:25:33Z
dc.date.issued2013-05-15eng
dc.identifier.issn1746-1596
dc.identifier.urihttps://hdl.handle.net/1956/7933
dc.description.abstractBackground: The differential diagnosis between primary and secondary breast cancers might be difficult, especially in poorly differentiated tumors. Thyroid Transcription Factor-1 (TTF-1) has been regarded as a reliable marker for lung or thyroid origin, with only occasional positive staining in other tumors. However, positive cases have recently been reported among primary breast carcinomas. Methods and results: Here, we analyzed expression of TTF-1 protein (clone SPT24) by immunohistochemical staining of sections from paraffin embedded tumor samples in 247 primary breast cancers from the population- based Norwegian Breast Cancer Screening Program. Positive staining (weak or strong) was observed in 7 cases (2,8%). As novel observations, positivity was demonstrated more frequently in estrogen receptor negative cases (14,0% vs. 1,4%; p = 0,004), highly proliferative tumors (8,8% vs. 1,1%; p = 0,008), tumors with a basal-like phenotype by showing expression of CK5/6 and/or P-cadherin (11,1% vs. 1,4%; p = 0,01), and tumors with blood vessel invasion (9,7% vs. 1,9%; p = 0,04). Also, TTF-1 was associated with histological grade 3 tumors compared with grade 1 or 2 tumors (7,7% vs. 1,5%; p = 0,04) as well as lymph node positive cases (5,2% vs. 1,8%; p = 0,03). Conclusions: Our population-based findings indicate that TTF-1 may be positive in approximately 3% of primary breast cancers, and positivity indicates an association with adverse prognostic factors.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0eng
dc.subjectThyroid transcription factor-1eng
dc.subjectBreast cancereng
dc.subjectBasal-like phenotypeeng
dc.subjectAdverse prognostic factorseng
dc.titleExpression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomasen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2013-08-23T08:50:36Z
dc.description.versionpublishedVersionen_US
dc.rights.holderTor A Klingen et al.; licensee BioMed Central Ltd.
dc.rights.holderCopyright 2013 Klingen et al.; licensee BioMed Central Ltd
dc.source.articlenumber80
dc.identifier.doihttps://doi.org/10.1186/1746-1596-8-80
dc.identifier.cristin1034161
dc.source.journalDiagnostic Pathology
dc.source.408


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