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dc.contributor.authorMidttun, Inaen_US
dc.date.accessioned2014-07-16T08:05:45Z
dc.date.available2014-07-16T08:05:45Z
dc.date.issued2014-05-15eng
dc.date.submitted2014-05-15eng
dc.identifier.urihttps://hdl.handle.net/1956/8160
dc.description.abstractLifestyle diseases like obesity and type 2 diabetes are highly prevalent worldwide, and represent a major public health concern. A potential link between lifestyle diseases and methylmercury exposure have been proposed in several studies. Methylmercury is an ubiquitous environmental contaminant emerging from both natural and anthropogenic sources. Methylmercury accumulates in the marine food chain and therefore represent a potential health risk for consumers. We aimed to investigate the potential role of methylmercury on obesity development and diabetes, evaluating dose response effects of methylmercury, and the effects on glucose tolerance and insulin sensitivity. In addition, we aimed to explore the accumulation of mercury in different tissues of the body. Obesity-prone C57BL/6 mice were exposed to an obesogenic high fat/high sucrose diet. Progressive concentrations of methylmercury-cysteine complex were added to the diets at 0.3 mg/kg, 1mg/kg, 3 mg/kg and 10 mg/kg. Our results demonstrated that chronic exposures to methylmercury did not induce obesity development: however, it attenuated obesity development and reduced basal insulin secretion due to the highest exposure (10 mg/kg). Further, we found a dose-dependent accumulation of mercury in several organs, with the highest levels accumulated in liver and pancreas.en_US
dc.format.extent2724649 byteseng
dc.format.mimetypeapplication/pdfeng
dc.language.isoengeng
dc.publisherThe University of Bergeneng
dc.subjectDiabeteseng
dc.subjectType 2 diabeteseng
dc.subjectOvervekteng
dc.subjectObesityeng
dc.subjectLivsstilsykdommereng
dc.subjectLifestyle diseaseseng
dc.subjectErnæringeng
dc.subjectNutritioneng
dc.subject.meshDiabetes Mellitus, Type 2eng
dc.subject.meshObesityeng
dc.subject.meshLife Styleeng
dc.titleDietary methylmercury accumulates in pancreas and reduces basal insulin secretion in miceen_US
dc.typeMaster thesis
dc.rights.holderCopyright the author. All rights reserved
dc.description.degreeMaster i Human ernæring
dc.description.localcodeMAMD-NUHUM
dc.description.localcodeNUHUM395
dc.subject.nus759999eng
fs.subjectcodeNUHUM395


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