dc.contributor.author | Frentz, Dineke | en_US |
dc.contributor.author | Van de Vijver, David A. M. C. | en_US |
dc.contributor.author | Abecasis, Ana B. | en_US |
dc.contributor.author | Albert, Jan | en_US |
dc.contributor.author | Hamouda, Osamah | en_US |
dc.contributor.author | Jørgensen, Louise B. | en_US |
dc.contributor.author | Kücherer, Claudia | en_US |
dc.contributor.author | Struck, Daniel | en_US |
dc.contributor.author | Schmit, Jean-Claude | en_US |
dc.contributor.author | Vercauteren, Jurgen | en_US |
dc.contributor.author | Åsjø, Birgitta | en_US |
dc.contributor.author | Balotta, Claudia | en_US |
dc.contributor.author | Beshkov, Danail | en_US |
dc.contributor.author | Camacho, Ricardo J. | en_US |
dc.contributor.author | Clotet, Bonaventura | en_US |
dc.contributor.author | Coughlan, Suzie | en_US |
dc.contributor.author | Griskevicius, Algirdas | en_US |
dc.contributor.author | Grossman, Zehava | en_US |
dc.contributor.author | Horban, Andrzej | en_US |
dc.contributor.author | Kolupajeva, Tatjana | en_US |
dc.contributor.author | Korn, Klaus | en_US |
dc.contributor.author | Kostrikis, Leondios G. | en_US |
dc.contributor.author | Liitsola, Kirsi | en_US |
dc.contributor.author | Linka, Marek | en_US |
dc.contributor.author | Nielsen, Claus | en_US |
dc.contributor.author | Otelea, Dan | en_US |
dc.contributor.author | Paraskevis, Dimitrios | en_US |
dc.contributor.author | Paredes, Roger | en_US |
dc.contributor.author | Poljak, Mario | en_US |
dc.contributor.author | Puchhammer-Stöckl, Elisabeth | en_US |
dc.contributor.author | Sönnerborg, Anders | en_US |
dc.contributor.author | Stanekova, Danica | en_US |
dc.contributor.author | Stanojevic, Maja | en_US |
dc.contributor.author | Van Wijngaerden, Eric | en_US |
dc.contributor.author | Wensing, Annemarie M. J. | en_US |
dc.contributor.author | Boucher, Charles A. B. | en_US |
dc.contributor.author | on behalf of the SPREAD Programme | en_US |
dc.date.accessioned | 2014-09-05T11:35:24Z | |
dc.date.available | 2014-09-05T11:35:24Z | |
dc.date.issued | 2014-07-21 | eng |
dc.identifier.issn | 1471-2334 | |
dc.identifier.uri | https://hdl.handle.net/1956/8424 | |
dc.description.abstract | Background: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data from the European Spread program. Methods: Clinical, epidemiological and virological data from 4317 patients newly diagnosed with HIV-1 infection between 2002 and 2007 were analysed. Patients were enrolled using a pre-defined sampling strategy. Results: The overall prevalence of TDRM in this period was 8.9% (95% CI: 8.1-9.8). Interestingly, significant changes over time in TDRM caused by the different drug classes were found. Whereas nucleoside resistance mutations remained constant at 5%, a significant decline in protease inhibitors resistance mutations was observed, from 3.9% in 2002 to 1.6% in 2007 (p = 0.001). In contrast, resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) doubled from 2.0% in 2002 to 4.1% in 2007 (p = 0.004) with 58% of viral strains carrying a K103N mutation. Phylogenetic analysis showed that these temporal changes could not be explained by large clusters of TDRM. Conclusion: During the years 2002 to 2007 transmitted resistance to NNRTI has doubled to 4% in Europe. The frequent use of NNRTI in first-line regimens and the clinical impact of NNRTI mutations warrants continued monitoring. | en_US |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | eng |
dc.subject | Europe | eng |
dc.subject | HIV-1 | eng |
dc.subject | Resistance | eng |
dc.subject | Transmission | eng |
dc.title | Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2014-08-27T11:26:16Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 Frentz et al.; licensee BioMed Central Ltd. | |
dc.rights.holder | Dineke Frentz et al.; licensee BioMed Central Ltd. | |
dc.source.articlenumber | 407 | |
dc.identifier.doi | https://doi.org/10.1186/1471-2334-14-407 | |
dc.identifier.cristin | 1164318 | |
dc.source.journal | BMC Infectious Diseases | |
dc.source.40 | 14 | |