dc.contributor.author | Apalset, Ellen M. | en_US |
dc.contributor.author | Gjesdal, Clara Gram | en_US |
dc.contributor.author | Ueland, Per Magne | en_US |
dc.contributor.author | Øyen, Jannike | en_US |
dc.contributor.author | Meyer, Klaus | en_US |
dc.contributor.author | Midttun, Øivind | en_US |
dc.contributor.author | Eide, Geir Egil | en_US |
dc.contributor.author | Tell, Grethe Seppola | en_US |
dc.date.accessioned | 2014-12-08T12:39:29Z | en_US |
dc.date.accessioned | 2014-12-09T08:36:09Z | en_US |
dc.date.accessioned | 2014-12-10T12:30:31Z | |
dc.date.available | 2014-12-10T12:30:31Z | |
dc.date.issued | 2014-05-10 | eng |
dc.identifier.issn | 0937-941X | |
dc.identifier.uri | https://hdl.handle.net/1956/8889 | |
dc.description.abstract | Summary The cytokine interferon gamma (IFN-γ) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. High levels of neopterin were associated with increased hip fracture risk, as were some of the kynurenines, suggesting a role of IFN-γ-mediated inflammation in the processes leading to hip fracture. Introduction Low-grade systemic inflammation has been associated with bone loss and risk of fractures. Interferon gamma (IFN-γ) initiates macrophage release of neopterin and also stimulates degradation of tryptophan along the kynurenine pathway as part of cell-mediated immune activation. Plasma neopterin and the kynurenine/tryptophan ratio (KTR) are thus markers of IFN-γ-mediated inflammation. Risk of hip fracture was investigated in relation to markers of inflammation and metabolites in the kynurenine pathway (kynurenines). Methods Participants (71 to74 years, N = 3,311) in the community-based Hordaland Health Study (HUSK) were followed for hip fractures from enrolment (1998–2000) until 31 December 2009. Plasma C-reactive protein (CRP), neopterin, KTR, and six kynurenines were investigated as predictors of hip fracture, using Cox proportional hazards regression analyses. Results A hazard ratio (HR) of 1.9 (95 % confidence interval (CI) 1.3–2.7) for hip fracture was found in the highest compared to the lowest quartile of neopterin (p trend across quartiles <0.001). CRP and KTR were not related to hip fracture risk. Among the kynurenines, a higher risk of fracture was found in the highest compared to the lowest quartiles of anthranilic acid and 3-hydroxykynurenine. For subjects in the highest quartiles of neopterin, CRP, and KTR compared to those in no top quartiles, HR was 2.5 (95 % CI 1.6–4.0). Conclusions This may indicate a role for low-grade immune activation in the pathogenic processes leading to hip fracture. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Springer | eng |
dc.rights | Attribution-NonCommercial CC BY-NC | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | eng |
dc.subject | Hip fracture | eng |
dc.subject | Inflammation | eng |
dc.subject | Kynurenine pathway | eng |
dc.subject | Neopterin | eng |
dc.subject | Osteoimmunology | eng |
dc.subject | Osteoporosis | eng |
dc.title | Interferon gamma (IFN-γ)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: The Hordaland Health Study | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2014-12-08T12:39:29Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 The Authors | |
dc.identifier.doi | https://doi.org/10.1007/s00198-014-2720-7 | |
dc.identifier.cristin | 1161436 | |
dc.source.journal | Osteoporosis International | |
dc.source.40 | 25 | |
dc.source.14 | 8 | |
dc.source.pagenumber | 2067-2075 | |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Rheumatology: 759 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 | nob |