Blar i Faculty of Mathematics and Natural Sciences på tidsskrift "International Journal of Molecular Sciences"
Viser treff 1-8 av 8
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BonMOLière: Small-Sized Libraries of Readily Purchasable Compounds, Optimized to Produce Genuine Hits in Biological Screens across the Protein Space
(Journal article; Peer reviewed, 2021)Experimental screening of large sets of compounds against macromolecular targets is a key strategy to identify novel bioactivities. However, large-scale screening requires substantial experimental resources and is ... -
Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
(Peer reviewed; Journal article, 2018-12-07)The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally ... -
Composition of Lignin-to-Liquid Solvolysis Oils from Lignin Extracted in a Semi-Continuous Organosolv Process
(Peer reviewed; Journal article, 2017-01-23)The interest and on-going research on utilisation of lignin as feedstock for production of renewable and sustainable aromatics is expanding and shows great potential. This study investigates the applicability of semi-continuously ... -
The Effect of Femtosecond Laser Irradiation and Plasmon Field on the Degree of Conversion of a UDMA-TEGDMA Copolymer Nanocomposite Doped with Gold Nanorods
(Journal article; Peer reviewed, 2022)In this work, the effects of femtosecond laser irradiation and doping with plasmonic gold nanorods on the degree of conversion (DC) of a urethane dimethacrylate (UDMA)–triethylene glycol dimethacrylate (TEGDMA) nanocomposite ... -
Mathematical modelling of nitric oxide/cyclic GMP/cyclic AMP signalling in platelets
(Peer reviewed; Journal article, 2018-02-19)Platelet activation contributes to normal haemostasis but also to pathologic conditions like stroke and cardiac infarction. Signalling by cGMP and cAMP inhibit platelet activation and are therefore attractive targets for ... -
Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish
(Journal article; Peer reviewed, 2023)DJ-1 is a redox sensitive protein with a wide range of functions related to oxidative stress protection. Mutations in the park7 gene, which codes for DJ-1 are associated with early onset familial Parkinson’s disease and ... -
Similarity-Based Methods and Machine Learning Approaches for Target Prediction in Early Drug Discovery: Performance and Scope
(Journal article; Peer reviewed, 2020-05)Computational methods for predicting the macromolecular targets of drugs and drug-like compounds have evolved as a key technology in drug discovery. However, the established validation protocols leave several key questions ... -
Skin Doctor: Machine learning models for skin sensitization prediction that provide estimates and indicators of prediction reliability
(Peer reviewed; Journal article, 2019-09-28)The ability to predict the skin sensitization potential of small organic molecules is of high importance to the development and safe application of cosmetics, drugs and pesticides. One of the most widely accepted methods ...