Blar i Faculty of Mathematics and Natural Sciences på tidsskrift "eLIFE"

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    • An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae 

      Kralt, Annemarie; Wojtynek, Matthias; Fischer, Jonas S.; Agote-Aran, Arantxa; Mancini, Roberta; Dultz, Elisa; Noor, Elad; Uliana, Federico; Tatarek-Nossol, Marianna; Antonin, Wolfram; Onishchenko, Evgeny; Medalia, Ohad; Weis, Karsten (Journal article; Peer reviewed, 2022)
      The nuclear pore complex (NPC) is the central portal for macromolecular exchange between the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear envelope (NE) during interphase, but the process ...

    • Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci 

      Han, Fan; Jamsandekar, Minal; Pettersson, Mats; Su, Leyi; Fuentes-Pardo, Angela P.; Davis, Brian W.; Bekkevold, Dorte; Berg, Florian; Casini, Michele; Dahle, Geir; Farrell, Edward D.; Folkvord, Arild; Andersson, Leif (Journal article; Peer reviewed, 2020)
      Atlantic herring is widespread in North Atlantic and adjacent waters and is one of the most abundant vertebrates on earth. This species is well suited to explore genetic adaptation due to minute genetic differentiation at ...

    • The effect of the COVID-19 pandemic on the gender gap in research productivity within academia 

      Lee, Kiran GL; Mennerat, Adele; Lukas, Dieter; Dugdale, Hannah L; Culina, Antica (Journal article; Peer reviewed, 2023)
      Using measures of research productivity to assess academic performance puts women at a disadvantage because gender roles and unconscious biases, operating both at home and in academia, can affect research productivity. The ...

    • Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network 

      Torres Cleuren, Yamila Nicole; Ewe, Chee Kiang; Chipman, Kyle C; Mears, Emily R; Wood, Cricket G; Al-Alami, Coco Emma Alma; Alcorn, Melissa R; Turner, Thomas L; Joshi, Pradeep M; Snell, Russell G; Rothman, Joel H (Peer reviewed; Journal article, 2019-08-15)
      Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, ...

    • Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate 

      Feng, Chungang; Pettersson, Mats; Lamichhaney, Sangeet; Rubin, Carl-Johan; Rafati, Nima; Casini, Michele; Folkvord, Arild; Andersson, Leif (Peer reviewed; Journal article, 2017-06-30)
      The Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (π = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation ...

    • Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution 

      Marti Solans, Josep; Børve, Aina; Bump, Paul; Hejnol, Andreas; Lynagh, Timothy Peter (Journal article; Peer reviewed, 2023)
      Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, ...

    • Rapid genome editing by CRISPR-Cas9-POLD3 fusion 

      Reint, Ganna; Li, Zhuokun; Labun, Kornel; Keskitalo, Salla; Soppa, Inkeri; Mamia, Katariina Aino Inkeri; Tolo, Eero; Szymanska, Monika; Meza-Zepeda, Leonardo A.; Lorenz, Susanne; Cieslar-Pobuda, Artur Grzegorz; Hu, Xian; Bodin, Diana L; Staerk, Judith; Valen, Eivind Dale; Schmierer, Bernhard; Varjosalo, Markku; Taipale, Jussi; Haapaniemi, Emma Maria (Journal article; Peer reviewed, 2021)
      Precision CRISPR gene editing relies on the cellular homology-directed DNA repair (HDR) to introduce custom DNA sequences to target sites. The HDR editing efficiency varies between cell types and genomic sites, and the ...