Browsing Department of Biological Sciences by Author "Gavgani, Fatemeh Mazloumi"

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    • Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins 

      Gavgani, Fatemeh Mazloumi; Slinning, Malene Skuseth; Morovicz, Andrea Papdine; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; D'Santos, Clive S.; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)
      Polyphosphoinositides (PPIns) play essential roles as lipid signaling molecules, and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin ...

    • Nucleolar roles of the PI3K pathway in cancer and differentiation 

      Gavgani, Fatemeh Mazloumi (Doctoral thesis, 2017-12-18)
      The phosphoinositide 3-kinase (PI3K) pathway is essential for many cellular functions including; proliferation, cell survival, differentiation and metabolism. Although this pathway has been well studied in the cytoplasm, ...

    • Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction 

      Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Edson, Amanda Jayne; Goris, Marianne; Altankhuyag, Altanchimeg; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2019)
      Biomolecular interactions between proteins and polyphosphoinositides (PPIn) are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the ...