Browsing Department of Physics and Technology by Author "Dahle, Tordis Johnsen"

Now showing items 1-8 of 8

    • Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET 

      Henjum, Helge; Dahle, Tordis Johnsen; Mairani, Andrea; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Boer, Camilla Grindeland; Redalen, Kathrine Røe; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)
      Introduction Tumor hypoxia is associated with poor treatment outcome. Hypoxic regions are more radioresistant than well-oxygenated regions, as quantified by the oxygen enhancement ratio (OER). In optimization of proton ...

    • The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors 

      Dahle, Tordis Johnsen; Rusten, Espen; Stokkevåg, Camilla Hanquist; Silvoniemi, Antti; Mairani, Andrea; Fjæra, Lars Fredrik; Rørvik, Eivind; Henjum, Helge; Wright, Pauliina; Boer, Camilla Grindeland; Forsback, Sarita; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)
      Introduction The increased radioresistance of hypoxic cells compared to well-oxygenated cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion of ...

    • Hypoxia adapted relative biological effectiveness models for proton therapy: a simulation study 

      Garrido Hernandez, Guillermo; Henjum, Helge; Høiskar, Marte Kåstad; Dahle, Tordis Johnsen; Redalen, Kathrine; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2022)
      In proton therapy, a constant relative biological effectiveness (RBE) factor of 1.1 is applied although the RBE has been shown to depend on factors including the Linear Energy Transfer (LET). The biological effectiveness ...

    • Inter-patient variations in relative biological efectiveness for craniospinal irradiation with protons 

      Ytre-Hauge, Kristian; Fjæra, Lars Fredrik; Rørvik, Eivind; Dahle, Tordis Johnsen; Dale, Jon Espen; Pilskog, Sara; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2020)
      Cranio-spinal irradiation (CSI) using protons has dosimetric advantages compared to photons and is expected to reduce risk of adverse effects. The proton relative biological effectiveness (RBE) varies with linear energy ...

    • The Organ Sparing Potential of Different Biological Optimization Strategies in Proton Therapy 

      Henjum, Helge; Dahle, Tordis Johnsen; Fjæra, Lars Fredrik; Rørvik, Eivind; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla H.; Mairani, Andrea; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2021)
      Purpose: Variable relative biological effectiveness (RBE) models allow for differences in linear energy transfer (LET), physical dose, and tissue type to be accounted for when quantifying and optimizing the biological ...

    • Performance Evaluation of a Small-Animal PET/CT System 

      Dahle, Tordis Johnsen (Master thesis, 2014-06-02)
      This master project is the first vendor-independent performance evaluation of the new nanoScan PET/CT system at the University of Bergen. A comprehensive performance evaluation of a novel scanner is very important, ...

    • Reduction of PTV margins for elective pelvic lymph nodes in online adaptive radiotherapy of prostate cancer patients 

      Brennsæter, John Alfred; Dahle, Tordis Johnsen; Moi, Jannicke Nøkling; Svanberg, Ingvild Førsvoll; Haaland, Gry Sandvik; Pilskog, Sara Margareta Cecilia (Journal article; Peer reviewed, 2023)
      Background Cone beam CT (CBCT) based online adaptive radiotherapy (oART) is a new development in radiotherapy. With oART, the requirements for planning target volume (PTV) margins differ from standard therapy because ...

    • Studies of the Relative Biological Effectiveness and Biological Dose in Proton and Carbon Ion Therapy 

      Dahle, Tordis Johnsen (Doctoral thesis, 2020-04-28)
      Protons and heavier ions have an increased relative biological effectiveness (RBE) compared to photons. While variable RBE models are applied clinically in carbon ion therapy, the RBE in proton therapy is accounted for ...