Blar i Department of Chemistry på tittel
Viser treff 136-155 av 568
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Development and validation of a novel method for serotonin and 5-hydroxyindole-acetic acid determination in plasma using liquid chromatography tandem mass spectrometry
(Master thesis, 2014-05-07)5-Hydroxytryptamine (5-HT) also known as serotonin is a biomarker in gastrointestinal disorder and several other pathological diseases where 5-HT and its metabolite 5-hydroxyindole-acetic acid are implicated. A sensitive ... -
Development of a novel extraction method for the analysis of prostaglandins and leukotrienes in fish liver by using liquid chromatography mass spectrometry
(Master thesis, 2015-09-06)Eicosanoids are the major metabolites of fatty acids and they have pro-inflammatory anti-inflammatory proprieties, their role and production in solid biological tissue is important due to correlation with many kinds of ... -
Development of a solid phase extraction method for evaluating the production of classic and nonclassic eicosanoids in human and fish cells using liquid chromatography tandem mass spectrometry
(Master thesis, 2014-03-14)Eicosanoids are the major metabolites of fatty acids and they are correlated with many kinds of diseases such as Alzheimer's, cancer and cardiovascular diseases. Usually, most of the eicosanoids derived from omega-6 fatty ... -
Development of a System for Microdosimetric Assessment of Clinical Proton Treatment Plans via Proton Energy Spectra
(Master thesis, 2024-06-03)Purpose: The biological effectiveness of proton radiation depends on variables beyond the absorbed dose. In particular, the dose deposition on a micrometer scale may be relevant for subcellular structures such as DNA. ... -
Development of an extraction method for the analysis of pro-inflammatory prostaglandin-E2 and leukotriene-B4 in human plasma by liquid chromatography tandem mass spectrometry
(Master thesis, 2013-02-21)A simple and rapid method for extracting PGE2 and LTB4 from human plasma and further determination by LC-MS/MS proposed and validated. Extracting solvents, formic acid (10 µL) and acetonitrile (140 µL) were added subsequently ... -
Development of an imaging method for in vivo single-cell tracking under high-noise conditions: a proof of principle
(Journal article; Peer reviewed, 2023)This paper reports the development of a positron imaging method for in vivo single-cell tracking under high-noise conditions. Following biological processes spatially and temporally at a single-cell level in a living ... -
Development of Endothelial Barrier Models for Nanotoxicity Testing
(Master thesis, 2022-02-07)Nanotechnology is a field of both research and innovation that is ever-growing. It Is the study and manipulation of matter at the nanoscale to produce materials and devices with enhanced properties. Industries are spending ... -
Development of Methodology for the Synthesis of Cytotoxic NHC-Ag-Complexes
(Master thesis, 2016-06-02)Recently disclosed silver N-heterocyclic carbene complexes holding 4-alkylated imidazoles have been proved to hold cytotoxic properties. In this work, derivatives of such alkylated imidazoles were synthesised to be complexed ... -
Development of methods based on NIR and Raman spectroscopies together with chemometric tools for the qualitative and quantitative analysis of gasoline
(Master thesis, 2019-09-28)Gasoline quality control is essential for SI engines performance and to reduce environmental impacts by generation of undesirable pollutants. Methods established by the American Society for Test and Materials (ASTM) are ... -
Development of Small Molecules that Post-Transitionally Stabilizes the SMN Protein for the Treatment of Spinal Muscular Atrophy
(Master thesis, 2019-08-31)Spinal Muscular Atrophy is an autosomal recessive neurodegenerative disorder, caused by the lack of SMN genes. Previous work done by Laboratory for Drug Discovery in Neurodegeneration (LDDN) at Brigham and Women’s Hospital ... -
Development, validation and application of in-silico methods to predict the macromolecular targets of small organic compounds
(Doctoral thesis, 2021-12-10)Computational methods to predict the macromolecular targets of small organic drugs and drug-like compounds play a key role in early drug discovery and drug repurposing efforts. These methods are developed by building ... -
Di-μ-chlorido-bis{bis[N,N-bis(trimethylsilyl)amido]titanium(III)}
(Journal article; Peer reviewed, 2017)The molecular structure of the title compound, [Ti2Cl2(C6H18NSi2)4], shows a binuclear motif of TiIII atoms, formulated as [Ti(μ-Cl)(N(SiMe3)2)2]2, with two μ-Cl atoms bridging two ((Me3Si)2N)2Ti moieties. The coordination ... -
Diels-Alder reactions with 1,1-diethoxybut-3-yn-2-one and some 1,1-diethoxy-5-hydroxyalk-3-yn-2-ones and their acetates
(Journal article; Peer reviewed, 2020) -
Dimethyl 3,3′-dimethoxybiphenyl-4,4′-dicarboxylate
(Peer reviewed; Journal article, 2014)In the title compound, C18H18O6, the biphenyl moiety is twisted with a dihedral angle of 29.11 (10)°. The carbomethoxy groups form C-C-C-O torsion angles of -18.3 (3) and -27.7 (3)° with the attached rings, as a result ... -
Direct Injection Electrospray Mass Spectrometry (DI-ESI-MS) and Liquid Chromatography Electrospray Mass Spectrometry (LC-ESI-MS) method development for characterisation of organic acids in petroleum and bio-oil samples
(Master thesis, 2017-05-09)Analysis and characterisation of complex mixtures such as petroleum and bio-oils are unarguably challenging. Finding suitable analytical method therefore needs to be considered carefully by analytical chemists. Electrospray ... -
Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene
(Journal article; Peer reviewed, 2024)Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated ... -
Discrimination of n-3 Rich Oils by Gas Chromatography
(Peer reviewed; Journal article, 2010-11-22)Exploring the capabilities of instrumental techniques for discriminating n-3 rich oils derived from animals is a very important though much neglected area that was emphasized more than 100 years ago. In this study the ... -
Dissecting peripheral protein-membrane interfaces
(Journal article; Peer reviewed, 2022-12-14)Peripheral membrane proteins (PMPs) include a wide variety of proteins that have in common to bind transiently to the chemically complex interfacial region of membranes through their interfacial binding site (IBS). In ... -
Distribution of fat, selenium, mercury, cadmium, arsenic, and persistent organic pollutants in Atlantic Bluefin Tuna (Thunnus thynnus) and implications for sampling and food safety
(Master thesis, 2021-10-01)The Atlantic bluefin tuna (ABFT)(Thunnus thynnus) has for a long time been absent off the Norwegian coast, but has started reappearing increasingly in the last decade. The ABFT has both high economic and cultural values, ... -
Djupneforståing i tradisjonelle prøvar - Ein kvalitativ studie av kapittelprøvar og elevsvar frå programfag i kjemi
(Master thesis, 2021-12-20)Skriftlege prøvar er ei mykje brukt vurderingsform i norsk skule, også i programfaga kjemi 1 og kjemi 2. Dei er nokså enkle å gjennomføre, ein får testa mykje på ein gong, og elevane er vane med at produksjon av skriftlege ...