Browsing Department of Chemistry by Author "Galster, Magdalena"

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    • Phenylethylene glycol-derived LpxC inhibitors with diverse Zn2+-binding groups 

      Galster, Magdalena; Loeppenberg, Marius; Galla, Fabian; Börgel, Frederik; Agoglitta, Oriana; Kirchmair, Johannes; Holl, Ralph (Peer reviewed; Journal article, 2019)
      The Zn2+-dependent bacterial deacetylase LpxC is a promising target for the development of novel antibiotics. Most of the known LpxC inhibitors carry a hydroxamate moiety as Zn2+-binding group. However, hydroxamic acids ...