Browsing Department of Chemistry by Author "Schubert, Ulrich"

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The intriguing Cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding

Solbak, Sara Marie Øie; Reksten, Tove Ragna; Wray, Victor; Bruns, Karsten; Horvli, Ole; Raae, Arnt Johan; Henklein, Petra; Henklein, Peter; Röder, Rene; Mitzner, David; Schubert, Ulrich; Fossen, Torgils (Peer reviewed; Journal article, 2010-10-04)

Background: Cyclophilin A (CypA) represents a potential target for antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication, although the mechanism through which ...
Mutation of the highly conserved ser-40 of the HIV-1 p6 gag protein to phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of gag

Hahn, Friedrich; Setz, Christian; Friedrich, Melanie; Rauch, Pia; Solbak, Sara Marie Øie; Frøystein, Nils Åge; Henklein, Petra; Votteler, Jörg; Fossen, Torgils; Schubert, Ulrich (Peer reviewed; Journal article, 2014-10-02)

The HIV-1 p6 Gag protein contains two late assembly (l-) domains that recruit proteins of the endosomal sorting complex required for transport (ESCRT) pathway to mediate membrane fission between the nascent virion and the ...