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dc.contributor.authorHejnol, Andreaseng
dc.contributor.authorMartindale, Mark Q.eng
dc.date.accessioned2015-01-26T13:52:51Z
dc.date.available2015-01-26T13:52:51Z
dc.date.issued2009-10-01eng
dc.identifier.issn1741-7007
dc.identifier.urihttps://hdl.handle.net/1956/9268
dc.description.abstractBackground: Hox genes are critical for patterning the bilaterian anterior-posterior axis. The evolution of their clustered genomic arrangement and ancestral function has been debated since their discovery. As acoels appear to represent the sister group to the remaining Bilateria (Nephrozoa), investigating Hox gene expression will provide an insight into the ancestral features of the Hox genes in metazoan evolution. Results: We describe the expression of anterior, central and posterior class Hox genes and the ParaHox ortholog Cdx in the acoel Convolutriloba longifissura. Expression of all three Hox genes begins contemporaneously after gastrulation and then resolves into staggered domains along the anterior-posterior axis, suggesting that the spatial coordination of Hox gene expression was present in the bilaterian ancestor. After early surface ectodermal expression, the anterior and central class genes are expressed in small domains of putative neural precursor cells co-expressing ClSoxB1, suggesting an evolutionary early function of Hox genes in patterning parts of the nervous system. In contrast, the expression of the posterior Hox gene is found in all three germ layers in a much broader posterior region of the embryo. Conclusion: Our results suggest that the ancestral set of Hox genes was involved in the anteriorposterior patterning of the nervous system of the last common bilaterian ancestor and were later co-opted for patterning in diverse tissues in the bilaterian radiation. The lack of temporal colinearity of Hox expression in acoels may be due to a loss of genomic clustering in this clade or, alternatively, temporal colinearity may have arisen in conjunction with the expansion of the Hox cluster in the Nephrozoa.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0eng
dc.titleCoordinated spatial and temporal expression of Hox genes during embryogenesis in the acoel Convolutriloba longifissuraeng
dc.typeJournal articleeng
dc.typePeer reviewedeng
dc.date.updated2013-08-28T16:41:59Z
dc.description.versionpublishedVersion
dc.description.versionPeer Reviewed
dc.rights.holderCopyright 2009 Hejnol and Martindale; licensee BioMed Central Ltd
dc.rights.holderAndreas Hejnol et al.; licensee BioMed Central Ltd.eng
dc.source.articlenumber65
dc.identifier.doihttps://doi.org/10.1186/1741-7007-7-65
dc.identifier.cristin500543
dc.source.journalBMC Biology
dc.source.407


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