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Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder
(Peer reviewed; Journal article, 2019)Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood ... -
Circadian rest-activity rhythms during benzodiazepine tapering covered by melatonin versus placebo add-on: data derived from a randomized clinical trial
(Peer reviewed; Journal article, 2016-10-13)Background: Patients with severe mental illness often suffer from disruptions in circadian rest-activity cycles, which might partly be attributed to ongoing psychopharmacological medication. Benzodiazepines are frequently ... -
Circadian typology and implications for adolescent sleep health. Results from a large, cross-sectional, school-based study
(Journal article; Peer reviewed, 2021)Study objectives To investigate circadian typology in a large, representative sample of Norwegian adolescents, and its implications for sleep health. Methods The sample included 3920 1st year high school students aged ... -
The circular RNome of primary breast cancer
(Peer reviewed; Journal article, 2019)Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs ... -
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival
(Peer reviewed; Journal article, 2014)Background The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The ... -
Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations
(Peer reviewed; Journal article, 2017-06)Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ... -
Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : Nested case-control study within Lung Cancer Cohort Consortium
(Peer reviewed; Journal article, 2019-01-03)Objectives: Inflammation may play an important role in lung cancer pathogenesis. Previous studies have suggested an association between C-reactive protein (CRP) as a marker of inflammation, and risk of lung cancer, but ... -
Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis
(Journal article; Peer reviewed, 2021)INTRODUCTION: Primary sclerosing cholangitis (PSC) is a progressive liver disease characterized by bile duct inflammation and fibrosis. The role of macrophages in PSC development and progression is less studied. Macrophage ... -
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
(Peer reviewed; Journal article, 2019-02)Background & Aims: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation. We aimed to investigate whether ... -
Circulating monocyte subsets in multiple myeloma patients receiving autologous stem cell transplantation – a study of the preconditioning status and the course until posttransplant reconstitution for a consecutive group of patients
(Journal article, 2019)Background Induction therapy of multiple myeloma patients prior to autologous stem cell transplantation has changed from conventional chemotherapy to treatment based on proteasome inhibitors or immunomodulatory drugs. We ... -
Circulating trimethylamine N-oxide levels do not predict 10-year survival in patients with or without coronary heart disease
(Journal article; Peer reviewed, 2022)Background Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for ... -
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease
(Journal article; Peer reviewed, 2020)Background The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). Riboflavin is a cofactor in TMAO synthesis. ... -
Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort
(Peer reviewed; Journal article, 2016-11-04)Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective ... -
Circumstances surrounding non-fatal opioid overdoses attended by ambulance services
(Peer reviewed; Journal article, 2017-05)Introduction and Aims: Opioid overdose fatalities are a significant concern globally. Non-fatal overdoses have been described as a strong predictor for future overdoses, and are often attended by the ambulance services. ... -
Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer
(Peer reviewed; Journal article, 2015-09-22)Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility ... -
The CLARION study: first report on safety findings in patients newly initiating treatment with cladribine tablets or fingolimod for multiple sclerosis
(Journal article; Peer reviewed, 2023)Objectives As part of the CLARION study: (1) characterize the incidence of severe infections, herpes zoster, and malignancies in patients newly initiating cladribine or fingolimod for relapsing multiple sclerosis (MS); ... -
Clarity and consistency in stillbirth reporting in Europe: why is it so hard to get this right?
(Journal article; Peer reviewed, 2022)Background Stillbirth is a major public health problem, but measurement remains a challenge even in high-income countries. We compared routine stillbirth statistics in Europe reported by Eurostat with data from the ... -
Classification and targeted treatment of patients with Non Specific Chronic Low Back Pain
(Doctoral thesis, 2011-04-27)Non-specific chronic low back pain (NSCLBP) disorders have proven highly resistant to change in spite of enormous resources directed at them. There is lack of evidence for single treatment interventions for patients with ... -
Classification of comorbidity in trauma: agreement and reliability of the pre-injury ASA-PS Scale
(Conference poster, 2012-03-22) -
Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers
(Peer reviewed; Journal article, 2019-07-31)Background Claudin-low breast cancer is a molecular subtype associated with poor prognosis and without targeted treatment options. The claudin-low subtype is defined by certain biological characteristics, some of which may ...