Blar i Faculty of Medicine på tittel

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    • Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis 

      Austevoll, Ivar Magne; Hermansen, Erland; Fagerland, Morten Wang; Storheim, Kjersti; Brox, Jens Ivar; Solberg, Tore; Rekeland, Frode; Franssen, Eric; Weber, Clemens; Brisby, Helena; Grundnes, Oliver; Algaard, Knut; Bøker, Tordis; Banitalebi, Hasan; Indrekvam, Kari; Hellum, Christian (Journal article; Peer reviewed, 2021)
      BACKGROUND In patients with lumbar spinal stenosis and degenerative spondylolisthesis, it is uncertain whether decompression surgery alone is noninferior to decompression with instrumented fusion. METHODS We conducted an ...

    • Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells 

      Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila; Djurovic, Srdjan (Journal article; Peer reviewed, 2020)
      Schizophrenia (SCZ) is a severe mental disorder with a high heritability. Although its pathophysiology is mainly unknown, dysregulated immune activation and inflammation have recently emerged as possible candidates in the ...

    • Decreased survival of medial pivot designs compared with cruciate-retaining designs in TKA without patellar resurfacing. 

      Øhrn, Frank-David; Gøthesen, Øystein; Lygre, Stein Håkon Låstad; Peng, Yi; Lian, Øystein Bjerkestrand; Lewis, Peter L; Furnes, Ove; Röhrl, Stephan Maximillian (Journal article; Peer reviewed, 2020)
      Background The medial pivot TKA design was introduced in the 1990s. These are fixed-bearing, medial-conforming implants with virtually no translation in the medial part of the knee, in contrast to the flat lateral part ...

    • Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays 

      Thunemann, Martin; Lu, Yichen; Liu, Xin; Kılıç, Kıvılcım; Desjardins, Michèle; Vandenberghe, Matthieu; Sadegh, Sanaz; Saisan, Payam A.; Cheng, Qun; Weldy, Kimberly L.; Lyu, Hongming; Djurovic, Srdjan; Andreassen, Ole Andreas; Dale, Anders; Devor, Anna; Kuzum, Duygu (Peer reviewed; Journal article, 2018-05-23)
      Recent advances in optical technologies such as multi-photon microscopy and optogenetics have revolutionized our ability to record and manipulate neuronal activity. Combining optical techniques with electrical recordings ...

    • Deep exploration of a CDKN1C mutation causing a mixture of Beckwith-Wiedemann and IMAGe syndromes revealed a novel transcript associated with developmental delay 

      Berland, Siren; Haukanes, Bjørn Ivar; Juliusson, Petur Benedikt; Houge, Gunnar (Journal article; Peer reviewed, 2022)
      Background: Loss-of-function mutations in CDKN1C cause overgrowth, that is, Beckwith-Wiedemann syndrome (BWS), while gain-of-function variants in the gene’s PCNA binding motif cause a growth-restricted condition called ...

    • Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2 

      Juliusson, Petur B.; Bruserud, Ingvild S.; Oehme, Ninnie Helen Bakken; Madsen, Andre; Forthun, Ingvild Halsør; Balthasar, Melissa Rajini; Viste, kristin; Jugessur, Astanand; Schell, Lawrence M.; Bjerknes, Robert; Roelants, Mathieu; Karen, Rosendahl (Journal article; Peer reviewed, 2023)
      Background The Bergen Growth Study 2 (BGS2) aims to characterise somatic and endocrine changes in healthy Norwegian children using a novel methodology. Subjects and methods A cross-sectional sample of 1285 children ...

    • Default-mode network functional connectivity is closely related to metabolic activity 

      Passow, Susanne; Specht, Karsten; Adamsen, Tom Christian; Biermann, Martin; Brekke, Njål; Craven, Alexander R.; Ersland, Lars; Grüner, Renate; Kleven-Madsen, Nina; Kvernenes, Ole Heine; Schwarzlmüller, Thomas; Olesen, Rasmus Aamand; Hugdahl, Kenneth (Peer reviewed; Journal article, 2015-06)
      Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ...

    • Defective i⁶A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA 

      Yarham, John W.; Lamichhane, Tek N.; Pyle, Angela; Mattijssen, Sandy; Baruffini, Enrico; Bruni, Francesco; Donnini, Claudia; Vassilev, Alex; He, Langping; Blakely, Emma L.; Griffin, Helen; Santibanez-Koref, Mauro; Bindoff, Laurence; Ferrero, Iliana; Chinnery, Patrick F.; McFarland, Robert; Maraia, Richard J.; Taylor, Robert W. (Peer reviewed; Journal article, 2014-06-05)
      Identifying the genetic basis for mitochondrial diseases is technically challenging given the size of the mitochondrial proteome and the heterogeneity of disease presentations. Using next-generation exome sequencing, we ...

    • Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease 

      Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos (Peer reviewed; Journal article, 2016-11-22)
      Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ...

    • Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid–sensitive hypoglycemia 

      St-Louis, Johanna L.; el Jellas, Khadija; Velasco, Kelly; Slipp, Brittany A.; Hu, Jiang; Helgeland, Geir; Steine, Solrun; De Jesus, Dario F.; Kulkarni, Rohit N.; Molven, Anders (Journal article; Peer reviewed, 2023)
      Congenital hyperinsulinism of infancy (CHI) can be caused by a deficiency of the ubiquitously expressed enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). To test the hypothesis that SCHAD-CHI arises from a specific ...

    • Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta 

      Gavasso, Sonia; Mosleth, Ellen Færgestad; Marøy, Tove Helene; Jørgensen, Katarina Mariann; Nakkestad, Hanne Linda; Gjertsen, Bjørn Tore; Myhr, Kjell-Morten; Vedeler, Christian A. (Peer reviewed; Journal article, 2014-02-19)
      Background: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. ...

    • Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality 

      Oddsson, Asmundur; Sulem, Patrick; Sveinbjornsson, Gardar; Arnadottir, Gudny A.; Steinthorsdottir, Valgerdur; Halldorsson, Gisli H.; Atlason, Bjarni A.; Oskarsson, Gudjon R.; Helgason, Hannes; Nielsen, Henriette Svarre; Westergaard, David; Karjalainen, Juha; Katrinardottir, Hildigunnur; Fridriksdottir, Run; Jensson, Brynjar O.; Tragante, Vinicius; Ferkingstad, Egil; Jónsson, Hákon; Gudjonsson, Sigurjon A.; Beyter, Doruk; Moore, Kristjan H.S.; Thordardottir, Helga B.; Kristmundsdottir, Snædis; Stefansson, Olafur A.; Rantapää Dahlqvist, Solbritt; Sonderby, Ida Elken; Didriksen, Maria; Stridh, Pernilla; Haavik, Jan; Tryggvadottir, Laufey; Frei, Oleksandr; Walters, G. Bragi; Kockum, Ingrid; Hjalgrim, Henrik; Olafsdottir, Thorunn A; Selbæk, Geir; Nyegaard, Mette; Erikstrup, Christian; Brodersen, Thorsten; Sævarsdottir, Sædis; Olsson, Tomas; Nielsen, Kaspar Rene; Haraldsson, Àsgeir; Bruun, Mie Topholm; Hansen, Thomas Folkmann; Steingrimsdottir, Thora; Jacobsen, Rikke Louise; Lie, Rolv T.; Djurovic, Srdjan; Alfredsson, Lars; Portilla, A.L.; Brunak, Søren; Havdahl, Alexandra; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with ...

    • Defining the Ethiopian Essential Health Service Package : Process, methods and cost-effectiveness evidence for the prioritisation of health interventions 

      Eregata, Getachew Teshome (Doctoral thesis, 2021-06-15)
      Background: All countries have signed up to the United Nations (UN) Sustainable Development Goals (SDGs), including Target 3.8 on achieving universal health coverage (UHC). UHC is realised when everyone has access to quality ...

    • Defining Transabdominal Intestinal Ultrasound Treatment Response and Remission in Inflammatory Bowel Disease: Systematic Review and Expert Consensus Statement 

      Ilvermarl, Johan FKF; Hansen, Tawnya; Goodsall, Thomas M.; Seidelin, Jakob B.; Al-Farhan, Heba; Allocca, Mariangela; Begun, Jakob; Bryant, Robert V.; Carter, Dan; Christensen, Britt; Dubinsky, Marla C.; Gecse, Krisztina B.; Kucharzik, Torsten; Lu, Cathy; Maaser, Christian; Maconi, Giovanni; Nylund, Kim; Palmela, Carolina; Wilson, Stephanie; Wilkens, Rune (Journal article; Peer reviewed, 2021)
      Background and Aims No consensus exists on defining intestinal ultrasound response, transmural healing, or transmural remission in inflammatory bowel disease, nor clear guidance for optimal timing of assessment during ...

    • Defining when specialised mental health care is needed: A focus group study 

      Nymoen, Marit; Biringer, Eva Aaker; Helgeland, Jostein; Hellesen, Harald Bjarne; Sande, Liv Alsaker; Hartveit, Miriam (Journal article; Peer reviewed, 2020)
      Background: Shared understanding between GPs and hospital specialists concerning when patients need specialised mental health care is important to ensure patients receive appropriate care. The large amount of rejected ...

    • The definition of immigrant status matters: impact of nationality, country of origin, and length of stay in host country on mortality estimates 

      Gimeno-Feliu, Luis Andrés; Calderón-Larrañaga, Amaia; Diaz, Esperanza; Laguna-Berna, Clara; Poblador-Plou, Beatriz; Coscollar-Santaliestra, Carlos; Prados-Torres, Alexandra (Peer reviewed; Journal article, 2019-02-28)
      Background: Mortality is a robust indicator of health and offers valuable insight into the health of immigrants. However, mortality estimates can vary significantly depending on the manner in which immigrant status is ...

    • Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv 

      Målen, Hiwa; Pathak, Sharad; Søfteland, Tina; De Souza, Gustavo A.; Wiker, Harald G. (Peer reviewed; Journal article, 2010-04-29)
      Background Membrane- and membrane-associated proteins are important for the pathogenicity of bacteria. We have analysed the content of these proteins in virulent Mycobacterium tuberculosis H37Rv using Triton X-114 ...

    • Deformation and initial stability in hip arthroplasty. Effect of neck geometry and fixation – an experimental cadaver study 

      Enoksen, Cathrine Harstad (Doctoral thesis, 2017-06-08)
      Introduction: The search for and development of the optimal joint implant include preclinical testing. Restoration of the individual and natural biomechanics in the hip joint is a central goal in hip arthroplasty, and can ...

    • Degenerative bony changes in the temporal component of the temporomandibular joint – review of the literature 

      Vîrlan, Maria Justina Roxana; Costea, Daniela Elena; Păun, Diana Loreta; Zamfir-Chiru-anton, Adina; Sterian, Alin Gabriel; Spînu, Arsenie Dan; Nimigean, Victor; Nimigean, Vanda Roxana (Journal article; Peer reviewed, 2022)
      Temporomandibular joint (TMJ) changes are quite frequent in adults, but not all changes are degenerative. A high prevalence of bone alterations in the TMJs was reported by different research groups. Disturbed remodeling ...

    • Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells 

      Kulikova, Veronika; Shabalin, Konstantin; Nerinovski, Kirill; Yakimov, Alexander; Svetlova, Maria; Solovjeva, Ljudmila; Kropotov, Andrey; Khodorkovskiy, Mikhail; Migaud, Marie E.; Ziegler, Mathias; Nikiforov, Andrey (Peer reviewed; Journal article, 2019-11-29)
      Nicotinamide adenine dinucleotide (NAD) is an essential redox carrier, whereas its degradation is a key element of important signaling pathways. Human cells replenish their NAD contents through NAD biosynthesis from ...