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Disulfiram, a ferroptosis inducer, triggers lysosomal membrane permeabilization by up-regulating ROS in glioblastoma
(Journal article; Peer reviewed, 2020)Introduction: Disulfiram (DSF), a drug used in the treatment of alcoholism since 1948, has been shown to have antitumor properties in various tumor types possibly due to the induction of a type cell death, ferroptosis, and ... -
The disvalue of death in the global burden of disease
(Peer reviewed; Journal article, 2018)In the Global Burden of Disease study, disease burden is measured as disability-adjusted life years (DALYs). The paramount assumption of the DALY is that it makes sense to aggregate years lived with disability (YLDs) and ... -
Diurnal variation of motor activity in adult ADHD patients analyzed with methods from graph theory
(Journal article; Peer reviewed, 2020-11)Attention-deficit /hyperactivity disorder (ADHD) is a common neurodevelopmental syndrome characterized by age-inappropriate levels of motor activity, impulsivity and attention. The aim of the present study was to study ... -
Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction
(Journal article; Peer reviewed, 2022)Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are ... -
Diversity of Rotavirus Strains in Children; Results From a Community-Based Study in Nepal
(Journal article; Peer reviewed, 2021)Objective: The objectives of this study were to describe the incidence and genetic diversity of Rotavirus (RV) infection among children up to 3 years of age in a community in Nepal. Methods: We investigated community-acquired ... -
'The divorce program': gendered experiences of HIV positive mothers enrolled in PMTCT programs - the case of rural Malawi
(Peer reviewed; Journal article, 2010-10-26)Background For HIV infected mothers in developing countries, choosing to enroll in a prevention of mother to child transmission (PMTCT) of HIV program is supposed to represent the first step towards protecting their child ... -
Dixon T2 imaging of vertebral bone edema: reliability and comparison with short tau inversion recovery
(Journal article; Peer reviewed, 2022)Background It is uncertain whether T2-weighted Dixon water images (DixonT2w) and short tau inversion recovery (STIR) are interchangeable when evaluating vertebral bone edema, or if one method is superior or visualizes the ... -
Dizziness and physical health are associated with pain in dizzy patients—A cross‐sectional study
(Journal article; Peer reviewed, 2021)Background and Purpose Associations between dizziness, health-related quality of life, and musculoskeletal pain have not been systematically explored in patients with vestibular disorders. Such knowledge may be important ... -
DNA Methylation Age Acceleration Is Not Associated with Age of Onset in Parkinson's Disease
(Journal article; Peer reviewed, 2023)Background Epigenetic clocks using DNA methylation (DNAm) to estimate biological age have become popular tools in the study of neurodegenerative diseases. Notably, several recent reports have shown a strikingly similar ... -
DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival
(Journal article; Peer reviewed, 2022)Background: Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ... -
DNA methylation in newborns conceived by assisted reproductive technology
(Journal article; Peer reviewed, 2022)Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo ... -
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
(Peer reviewed; Journal article, 2010-03-25)Background: Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, we aimed to ... -
DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy
(Peer reviewed; Journal article, 2017-04)Background: Maternal smoking during pregnancy, especially when sustained, leads to numerous adverse health outcomes in offspring. Pregnant women disproportionately underreport smoking and smokers tend to have lower follow-up ... -
The DNA methylome of cervical cells can predict the presence of ovarian cancer
(Journal article; Peer reviewed, 2022)The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived ... -
DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer
(Peer reviewed; Journal article, 2015-04-21)Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ... -
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion
(Journal article; Peer reviewed, 2021)Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases ... -
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients
(Journal article; Peer reviewed, 2022)Purpose: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that ... -
DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells
(Peer reviewed; Journal article, 2016-07-09)DNA topoisomerases (Topo) are multifunctional enzymes resolving DNA topological problems such as those arising during DNA replication, transcription and mitosis. Mammalian cells express 2 class II isoforms, Topoisomerases ... -
A DNA vaccine that targets hemagglutinin to antigen-presenting cells protects mice against H7 influenza
(Peer reviewed; Journal article, 2017-12)Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently, no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires the ability ... -
DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease
(Peer reviewed; Journal article, 2014-08-20)Background: Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of ...