Blar i Faculty of Medicine på tittel
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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
(Peer reviewed; Journal article, 2018-10-08)Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the ... -
Applying the theory of planned behaviour to explain HIV testing in antenatal settings in Addis Ababa - a cohort study
(Peer reviewed; Journal article, 2011-08-18)Background: To facilitate access to the prevention of mother-to-child HIV transmission (PMTCT) services, HIV counselling and testing are offered routinely in antenatal care settings. Focusing a cohort of pregnant women ... -
Appraising Drugs Based on Cost-effectiveness and Severity of Disease in Norwegian Drug Coverage Decisions
(Journal article; Peer reviewed, 2022)Importance: Rising health care costs are a major health policy challenge globally. Norway has implemented a priority-setting system intended to balance cost-effectiveness and concerns for fair distribution, but little is ... -
Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum
(Peer reviewed; Journal article, 2016-01-04)The World Health Organization (WHO) calls for an accurate, rapid, and simple point-of-care (POC) test for the diagnosis of pediatric tuberculosis (TB) in order to make progress “Towards Zero Deaths”. Whereas the sensitivity ... -
Appropriate waist circumference cut points for identifying insulin resistance in black youth: a cross sectional analysis of the 1986 Jamaica birth cohort
(Peer reviewed; Journal article, 2010-12-07)Background While the International Diabetes Federation (IDF) has ethnic specific waist circumference (WC) cut-points for the metabolic syndrome for Asian populations it is not known whether the cut-points for black populations ... -
Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults
(Peer reviewed; Journal article, 2010-06-10)Background Arachnoid cyst (AC) fluid has not previously been compared with cerebrospinal fluid (CSF) from the same patient. ACs are commonly referred to as containing "CSF-like fluid". The objective of this study was to ... -
Arc expression and protein-protein interactions in a mouse model of Alzheimer’s disease. Exercise- and novelty-induced changes in Arc, BDNF, and PS1 expression and Arc PS1 interaction in APP/PS1 and WT mice
(Master thesis, 2017)The overarching goal of this project was to help elucidate how some of the molecular mechanisms behind memory and learning differ between healthy brains and those with neurodegenerative diseases, specifically by studying ... -
Arc interacts with the integral endoplasmic reticulum protein, calnexin
(Peer reviewed; Journal article, 2017-09-20)Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum ... -
Arc is a flexible modular protein capable of reversible self-oligomerization
(Peer reviewed; Journal article, 2015)The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ... -
The Arc of synaptic memory
(Peer reviewed; Journal article, 2010)The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. ... -
Arc protein-protein interactions in long-term potentiation in the rat dentate gyrus in vivo
(Master thesis, 2014-06-02)Synaptic plasticity is the ability of neuronal synapses to change in strength over time, and is considered to be a foundation for learning and memory. Long-term potentiation (LTP) is a widely studied form of synaptic ... -
Are 90% of deaths from cancer caused by metastases?
(Peer reviewed; Journal article, 2019)Numerous publications have stated that metastases are responsible for 90% of cancer deaths, but data underlying this assertion has been lacking. Our objective was to determine what proportions of cancer deaths are caused ... -
Are attitudes in employees of public employment service in line with the principles of individual placement and support? A questionnaire-based survey
(Journal article; Peer reviewed, 2022)A high proportion of people with severe mental illness (SMI) want to work, consider it essential for recovery, yet employment rates are low. Many employees in public employment services (PES) work according to traditional ... -
Are children with tuberculosis in Pakistan managed according to National programme policy guidelines? A study from 3 districts in Punjab
(Peer reviewed; Journal article, 2010-11-30)Background: The adherence to policies of National TB Control Programme (NTP) to manage a case of tuberculosis (TB) is a fundamental step to have a successful programme in any country. Childhood TB services faces an unmet ... -
Are Chronic Pain Patients with Dementia Being Undermedicated?
(Journal article; Peer reviewed, 2021)In dementia, neuropathological changes alter the perception and expression of pain. For clinicians and family members, this knowledge gap leads to difficulties in recognizing and assessing chronic pain, which may consequently ... -
Are general practitioners characteristics associated with the quality of type 2 diabetes care in general practice? Results from the Norwegian ROSA4 study from 2014
(Peer reviewed; Journal article, 2018-05-02)Objective: To explore the associations between general practitioners (GPs) characteristics such as gender, specialist status, country of birth and country of graduation and the quality of care for patients with type 2 ... -
Are infants exposed to antimicrobials during the first 3 months of life at increased risk of recurrent use? An explorative data-linkage study
(Journal article; Peer reviewed, 2022)Objectives: To investigate whether infants exposed to antimicrobials in hospital during the first 3 months of life had an increased risk of ambulatory antimicrobial use during the following year compared with infants not ... -
Are MRI high-signal changes of alar and transverse ligaments in acute whiplash injury related to outcome?
(Peer reviewed; Journal article, 2010-11-11)Background: Upper neck ligament high-signal changes on magnetic resonance imaging (MRI) have been found in patients with whiplash-associated disorders (WAD) but also in non-injured controls. The clinical relevance of such ... -
Are patients with pulmonary tuberculosis identified by active and by passive case detection different? A cross-sectional study in Pakistan
(Journal article; Peer reviewed, 2022)Objectives Our objective was to compare the characteristics of patients with pulmonary tuberculosis (TB) identified through “extended contact screening” (ECS) with those of patients identified through routine passive case ... -
Are severely injured trauma victims in Norway offered advanced pre-hospital care? National, retrospective, observational cohort
(Peer reviewed; Journal article, 2017-08)Background: Studies of severely injured patients suggest that advanced pre‐hospital care and/or rapid transportation provides a survival benefit. This benefit depends on the disposition of resources to patients with the ...