Blar i Faculty of Medicine på tittel
Viser treff 4029-4048 av 8748
-
Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism
(Journal article; Peer reviewed, 2023-04-25)The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small ... -
Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach
(Journal article; Peer reviewed, 2023)Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ... -
Identification of diarrheagenic Escherichia coli isolated from infants and children in Dar es Salaam, Tanzania
(Peer reviewed; Journal article, 2007-08-09)Background: Relatively few studies have been done in Tanzania to detect and classify diarrheagenic Escherichia coli (DEC) strains among children with diarrhea. This study aimed at investigating DEC among children in Dar ... -
Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy
(Peer reviewed; Journal article, 2014-10-01)Background: Maternal smoking during pregnancy is associated with significant infant morbidity and mortality, and may influence later disease risk. One mechanism by which smoking (and other environmental factors) might have ... -
Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid
(Peer reviewed; Journal article, 2013)Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact. When cells are exposed to high concentrations of okadaic ... -
Identification of gait domains and key gait variables following hip fracture
(Peer reviewed; Journal article, 2015-11-18)Background Restoration of gait is an important goal of rehabilitation after hip fracture. Numerous spatial and temporal gait variables have been reported in the literature, but beyond gait speed, there is little agreement ... -
Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment
(Peer reviewed; Journal article, 2020)Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified ... -
Identification of genetic loci shared between schizophrenia and the Big Five personality traits
(Peer reviewed; Journal article, 2017-05-22)Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between ... -
Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder
(Peer reviewed; Journal article, 2019)Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, ... -
Identification of host biomarkers from dried blood spots for monitoring treatment response in extrapulmonary tuberculosis
(Journal article; Peer reviewed, 2023)There is a lack of objective tools for monitoring treatment response in extrapulmonary tuberculosis (EPTB). This study aimed to explore the utility of inflammatory biomarkers from the dry blood spots (DBS) as a tool for ... -
Identification of immune-related genes contributing to the development of glioblastoma using weighted gene co-expression network analysis
(Journal article; Peer reviewed, 2020)Background: The tumor microenvironment (TME) of human glioblastoma (GBM) exhibits considerable immune cell infiltration, and such cell types have been shown to be widely involved in the development of GBM. Here, weighted ... -
Identification of inhibitors of tryptophan hydroxylase 1
(Master thesis, 2014-05-20)Background: In this study we use molecular docking to find compounds that interact with the enzyme tryptophan hydroxylase (TPH), followed by experimental validation. TPH is a tetrahydrobiopterin (BH4) dependent enzyme that ... -
Identification of microRNAs from medicinal plant Murraya Koenigii by high-throughput sequencing and their functional implications in secondary metabolite biosynthesis
(Journal article; Peer reviewed, 2022)MicroRNAs (miRNAs) are small noncoding RNA molecules that play crucial post-transcriptional regulatory roles in plants, including development and stress-response signaling. However, information about their involvement in ... -
Identification of nine new susceptibility loci for endometrial cancer
(Peer reviewed; Journal article, 2018-08-09)Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial ... -
Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
(Journal article; Peer reviewed, 2023)Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity and overlapping symptoms. However, the causative mechanisms underlying this relationship are poorly understood. Here we aimed to ... -
Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms
(Peer reviewed; Journal article, 2015-07-02)Background: Human T cell leukemia virus type 1 (HTLV-1) gene expression is controlled by the key regulatory proteins Tax and Rex. The concerted action of these proteins results in a two-phase kinetics of viral expression ... -
Identification of pharmacological chaperones for Phenylalanine Hydroxylase. A virtual screening approach to discover novel drug candidates for treatment of phenylketonuria
(Master thesis, 2014-05-20)Phenylalanine hydroxylase (PAH) is an enzyme that catalyses the hydroxylation of phenylalanine into tyrosine in the liver, which is the rate-limiting step in phenylalanine catabolism. PAH is a non-heme iron-dependent enzyme ...