Blar i Faculty of Medicine på tittel
Viser treff 4508-4527 av 8751
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Integrated Genomic Analysis of the 8q24 Amplification in Endometrial Cancers Identifies ATAD2 as Essential to MYC-Dependent Cancers
(Peer reviewed; Journal article, 2013-02-05)Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC. To explore the roles of the genes most ... -
Integrated treatment of hepatitis C virus infection among people who inject drugs: A multicenter randomized controlled trial (INTRO-HCV)
(Journal article; Peer reviewed, 2021)Background The standard pathways of testing and treatment for hepatitis C virus (HCV) infection in tertiary healthcare are not easily accessed by people who inject drugs (PWID). The aim of this study was to evaluate the ... -
Integrated treatment of hepatitis C virus infection among people who inject drugs: study protocol for a randomised controlled trial (INTRO-HCV)
(Peer reviewed; Journal article, 2019-11-08)Background: A large proportion of people who inject drugs (PWID) living with hepatitis C virus (HCV) infection have not been treated. It is unknown whether inclusion of HCV diagnostics and treatment into integrated substance ... -
Integrating pediatric TB services into child healthcare services in Africa: study protocol for the INPUT cluster-randomized stepped wedge trial
(Journal article; Peer reviewed, 2020)Background Tuberculosis is among the top-10 causes of mortality in children with more than 1 million children suffering from TB disease annually worldwide. The main challenge in young children is the difficulty in ... -
Integrating protein structural dynamics and evolutionary analysis with Bio3D
(Peer reviewed; Journal article, 2014-12-10)Background: Popular bioinformatics approaches for studying protein functional dynamics include comparisons of crystallographic structures, molecular dynamics simulations and normal mode analysis. However, determining how ... -
Integration of ear and hearing care into primary health care in Malawi with special reference to task-sharing.
(Doctoral thesis, 2020-04-29)Introduction: The prevalence of hearing impairment has increased rapidly over the last two decades. The burden is higher in Africa and South East Asia than in richer parts of the world. The majority of this hearing impairment ... -
Integration of smoking cessation into standard treatment for patients receiving opioid agonist therapy who are smoking tobacco: protocol for a randomised controlled trial (ATLAS4LAR)
(Journal article; Peer reviewed, 2022)Background About 85% of patients receiving opioid agonist therapy (OAT) for opioid dependence are smoking tobacco. Although smoke-related pulmonary diseases are significant contributors to morbidity and mortality, few ... -
Integration of tuberculosis services in Taiwan, 2001: challenges and opportunities
(Doctoral thesis, 2012-10-02) -
Integrin a11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression
(Peer reviewed; Journal article, 2017-04)BACKGROUND: Cancer-associated fibroblasts (CAFs) were shown to be important for tumour progression in head and neck squamous cell carcinomas (HNSCCs). Their heterogeneity and lack of specific markers is increasingly ... -
Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts
(Journal article; Peer reviewed, 2020)The link between integrin activity regulation and cellular mechanosensing of tissue rigidity, especially on different extracellular matrix ligands, remains poorly understood. Here, we find that primary mouse mammary gland ... -
Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation
(Peer reviewed; Journal article, 2019)Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both ... -
Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?
(Journal article; Peer reviewed, 2022)There is currently an increased interest in understanding the role of the tumor microenvironment (TME) in tumor growth and progression. In this context the role of integrins in cancer-associated fibroblasts (CAFs) will ... -
Integrin α11β1 is a receptor for collagen XIII
(Journal article; Peer reviewed, 2021)Collagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that collagen XIII modulates tissue development and homeostasis. Integrins are a family of receptors ... -
Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes
(Peer reviewed; Journal article, 2020)Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. ... -
Intense pulsed light treatment in meibomian gland dysfunction: Past, present, and future
(Journal article; Peer reviewed, 2023)Dry eye disease is a highly prevalent condition, which can substantially impair quality of life, work productivity, and vision. It is considered an inflammatory disease and the most common cause is meibomian gland dysfunction. ... -
Intensified follow-up of patients with type 1 diabetes and poor glycaemic control: A multicentre quality improvement collaborative based on data from the Norwegian Diabetes Register for Adults
(Journal article; Peer reviewed, 2023)Background Patients with type 1 diabetes mellitus (T1DM) and poor glycaemic control are at high risk of developing microvascular and macrovascular complications. The aim of this study was to determine if a quality improvement ... -
Intensity-modulated radiotherapy of pelvic lymph nodes in locally advanced prostate cancer: planning procedures and early experiences
(Peer reviewed; Journal article, 2008-07-15) -
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
(Peer reviewed; Journal article, 2010-07-09)Background Several observations suggest that immunological events early after chemotherapy, possibly during the period of severe treatment-induced cytopenia, are important for antileukemic immune reactivity in acute myeloid ... -
Intensive Group Training in a Local Community Setting for Children with Cerebral Palsy. Methodological Aspects and Change in Motor Functioning
(Doctoral thesis, 2010-02-18)The purpose of this thesis was to examine measurement properties of three outcome measures of motor function for children with cerebral palsy (CP), and to investigate change in their motor functioning following three weeks ...