Browsing Faculty of Medicine by Title
Now showing items 8809-8828 of 9409
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Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
(Journal article; Peer reviewed, 2023)Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from ... -
Transcriptomic landscape of blood platelets in healthy donors
(Journal article; Peer reviewed, 2021)Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy ... -
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
(Journal article; Peer reviewed, 2022-06-02)Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ... -
Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells
(Peer reviewed; Journal article, 2015-01-09)Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, ... -
Transfer of newborns to neonatal care unit: a registry based study in Northern Tanzania
(Peer reviewed; Journal article, 2011-10-04)Background: Reduction in neonatal mortality has been slower than anticipated in many low income countries including Tanzania. Adequate neonatal care may contribute to reduced mortality. We studied factors associated with ... -
Transforming subjectivities in psychiatric care
(Peer reviewed; Journal article, 2009)This paper is based upon ethnographic fieldwork in a Norwegian psychiatric unit practicing a psycho-educational treatment of young adults diagnosed with schizophrenia. An aim of the programme is that patients learn to ... -
Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial
(Peer reviewed; Journal article, 2013-05-23)Background: Transfusion of red blood cells (RBC) is recommended in septic shock and the majority of these patients receive RBC transfusion in the intensive care unit (ICU). However, benefit and harm of RBCs have not been ... -
Transgenerational and intergenerational epigenetic inheritance in allergic diseases
(Peer reviewed; Journal article, 2018-09)It has become clear that early life (including in utero exposures) is a key window of vulnerability during which environmental exposures can alter developmental trajectories and initiate allergic disease development. ... -
Transitioning from transrectal to transperineal prostate biopsy using a freehand cognitive approach
(Journal article; Peer reviewed, 2024)Objectives To report a single-centre experience of a complete transition from transrectal (TR) to transperineal (TP) prostate biopsy under local anaesthesia using a freehand cognitive coaxial approach and without use ... -
Translating global recommendations on HIV and infant feeding to the local context : the development of culturally sensitive counselling tools in the Kilimanjaro Region, Tanzania
(Peer reviewed; Journal article, 2006-10-03)Background: This paper describes the process used to develop an integrated set of culturally sensitive, evidence-based counselling tools (job aids) by using qualitative participatory research. The aim of the intervention ... -
Translating new evidence into clinical practice: a quasi-experimental controlled before–after study evaluating the effect of a novel outreach mentoring approach on knowledge, attitudes and confidence of health workers providing HIV and infant feeding counselling in South Africa
(Journal article; Peer reviewed, 2020)Objectives We report the effectiveness of a mentoring approach to improve health workers’ (HWs’) knowledge, attitudes and confidence with counselling on HIV and infant feeding. Design Quasi-experimental controlled ... -
Translating weight loss into agency: Men’s experiences 5 years after bariatric surgery
(Peer reviewed; Journal article, 2015-06-09)Fewer men than women with severe obesity undergo bariatric surgery for weight loss, and knowledge about men's situation after surgery, beyond medical status, is lacking. Our aim was to explore men's experiences with life ... -
Translation and validation of the Alberta Context Tool for use in Norwegian nursing homes
(Journal article; Peer reviewed, 2021)Purpose: Organizational context is recognized as important for facilitating evidence-based practice and improving patient outcomes. Organizational context is a complex construct to measure and appropriate instruments that ... -
Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data
(Journal article; Peer reviewed, 2019)Background Many data are available on expansion protocols for mesenchymal stromal cells (MSCs) for both experimental settings and manufacturing for clinical trials. However, there is a lack of information on translation ... -
Translation of Biophysical Environment in Bone into Dynamic Cell Culture under Flow for Bone Tissue Engineering
(Journal article; Peer reviewed, 2023)Bone is a dynamic environment where osteocytes, osteoblasts, and mesenchymal stem/progenitor cells perceive mechanical cues and regulate bone metabolism accordingly. In particular, interstitial fluid flow in bone and bone ... -
Translation, adaptation, validation and performance of the American Weight Efficacy Lifestyle Questionnaire Short Form (WEL-SF) to a Norwegian version: a cross-sectional study
(Peer reviewed; Journal article, 2014-09-16)Background. Researchers have emphasized a need to identify predictors that can explain the variability in weight management after bariatric surgery. Eating self-efficacy has demonstrated predictive impact on patients’ ... -
Translation, cross-cultural adaption and measurement properties of the evidence-based practice profile
(Peer reviewed; Journal article, 2017-01-13)Background: The evidence-based practice profile (EBP2) questionnaire assesses students’ self-reported knowledge, behaviour and attitudes related to evidence-based practice. The aim of this study was to translate and ... -
Translation, transcultural adaptation, reliability and validation of the pelvic organ prolapse quality of life (P-QoL) in Amharic
(Peer reviewed; Journal article, 2019)Background: The Prolapse Quality of Life (P-QoL) is a disease-specific instrument designed to measure the health-related quality of life in women with prolapse; however, there is no Amharic version of the instrument. The ... -
Translational ethics: an analytical framework of translational movements between theory and practice and a sketch of a comprehensive approach
(Peer reviewed; Journal article, 2014-09-30)Background: Translational research in medicine requires researchers to identify the steps to transfer basic scientific discoveries from laboratory benches to bedside decision-making, and eventually into clinical practice. ... -
Translational ethics: An analytical framework of translational movements between theory and practice and a sketch of a comprehensive approach
(Peer reviewed; Journal article, 2014-09-30)Background: Translational research in medicine requires researchers to identify the steps to transfer basic scientific discoveries from laboratory benches to bedside decision-making, and eventually into clinical practice. ...