Browsing Faculty of Medicine by Title
Now showing items 4804-4823 of 8740
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Label-free impedance flow cytometry for nanotoxicity screening
(Peer reviewed; Journal article, 2020)The development of reliable and cost-efficient methods to assess the toxicity of nanomaterials (NMs) is critical for the proper identification of their impact on human health and for ensuring a safe progress of nanotechnology. ... -
Label-free monitoring of uptake and toxicity of endoprosthetic wear particles in human cell cultures
(Peer reviewed; Journal article, 2018)The evaluation of the biological effects of endoprosthetic wear particles on cells in vitro relies on a variety of test assays. However, most of these methods are susceptible to particle-induced interferences; therefore, ... -
Label-free quantitative proteomic analysis of the oral bacteria Fusobacterium nucleatum and Porphyromonas gingivalis to identify protein features relevant in biofilm formation
(Journal article; Peer reviewed, 2021)Background The opportunistic pathogens Fusobacterium nucleatum and Porphyromonas gingivalis are Gram-negative bacteria associated with oral biofilm and periodontal disease. This study investigated interactions between F. ... -
Labor epidural analgesia and subsequent risk of offspring autism spectrum disorder and attention-deficit/hyperactivity disorder: A cross-national cohort study of over 4.5 million individuals and their siblings in Finland, Norway, and Sweden
(Journal article; Peer reviewed, 2023)Background A recent study has suggested that labor epidural analgesia may be associated with increased rates of offspring autism spectrum disorder. Subsequent replication attempts have lacked sufficient power to confidently ... -
Laboratory contamination in airway microbiome studies
(Peer reviewed; Journal article, 2019-08-14)Background The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have ... -
Laboratory tests in out-of-hours services in Norway. Studies with special emphasis on use and consequences of C-reactive protein test in children
(Doctoral thesis, 2017-05-31)Background: Children with infections and respiratory symptoms have the highest contact rate with Norwegian out-of-hours (OOH) services, especially in the youngest age group, and during the winter season. Many contacts are ... -
Labour onset and early labour. An exploration of first-time mothers’ and midwives’ experiences
(Doctoral thesis, 2011-10-28)This dissertation is about how women experience waiting for the onset of labour, and how first-time mothers and midwives communicate during the early phases of labour. Most women in Norway give birth in public hospitals, ... -
Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson’s Disease Cohorts
(Journal article; Peer reviewed, 2021)Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson’s disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on ... -
Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis
(Journal article; Peer reviewed, 2020)Liver and adipose tissues play important roles in the regulation of systemic glucose and lipid metabolism. Extracellular matrix synthesis and remodelling are significantly altered in these tissues in obesity and type 2 ... -
Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma
(Peer reviewed; Journal article, 2017)Neo-angiogenesis represents an important factor for the delivery of oxygen and nutrients to a growing tumour, and is considered to be one of the main pathodiagnostic features of glioblastomas (GBM). Anti-angiogenic therapy ... -
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis
(Journal article; Peer reviewed, 2022)Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, ... -
Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients
(Journal article; Peer reviewed, 2021)Purpose: Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have ... -
The laminin response in inflammatory bowel disease: Protection or malignancy?
(Peer reviewed; Journal article, 2014-10-27)Laminins (LM), basement membrane molecules and mediators of epithelial-stromal communication, are crucial in tissue homeostasis. Inflammatory Bowel Diseases (IBD) are multifactorial pathologies where the microenvironment ... -
Langtidsoppfølging av pasienter med Oral Lichen Planus - en retrospektiv studie
(Master thesis, 2010-02-01)The aim of this study was to evaluate progression of clinical appearance and symptoms in patients diagnosed with oral lichen planus (OLP), and observe if any malign transformation occurred. The study was retrospective and ... -
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero – the Norwegian Mother and Child Cohort Study
(Peer reviewed; Journal article, 2020)Background and purpose: The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8 years of mothers with epilepsy. Methods: The study ... -
Laparoscopic rectal cancer resection yields comparable clinical and oncological results with shorter hospital stay compared to open access: a 5-year national cohort
(Journal article; Peer reviewed, 2023)Purpose Although widely applied, the results following laparoscopic rectal resection (LRR) compared to open rectal resection (ORR) are still debated. The aim of this study was to assess clinical short- and long-term ... -
Laparoskopisk gastrisk bypassoperasjon versus livsstilsbehandling av unge med sykelig overvekt
(Journal article; Peer reviewed, 2020)BAKGRUNN Kunnskapsgrunnlaget om effekten av og komplikasjoner ved vektreduserende kirurgi hos ungdom er mangelfullt. Hovedformålet med 4XL-studien er å avklare om laparoskopisk Roux-en-Y gastrisk bypassoperasjon (LGBP) ... -
A large community outbreak of waterborne giardiasis- delayed detection in a non-endemic urban area
(BMC Public Health 6(141), Peer reviewed; Journal article, 2006-05-25)Background: Giardia is not endemic in Norway, and more than 90% of reported cases acquire the infection abroad. In late October 2004, an increase in laboratory confirmed cases of giardiasis was reported in the city of ... -
Large-scale external validation and comparison of prognostic models: An application to chronic obstructive pulmonary disease
(Peer reviewed; Journal article, 2018-03-02)Background: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease ... -
Large-scale genomics unveil polygenic architecture of human cortical surface area
(Peer reviewed; Journal article, 2015-07-20)Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence ...