Browsing Faculty of Medicine by Title
Now showing items 9296-9315 of 9778
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U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells
(Peer reviewed; Journal article, 2014-08)It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination ... -
UCP1 induction during recruitment of Brown Adipocytes in White Adipose tissue is dependent on Cyclooxygenase activity
(Peer reviewed; Journal article, 2010-06-30)Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and ... -
UGT1A4 og UGT2B15 enkeltnukleotidpolymorfismer. Etablering av real time PCR metoder og betydning for tamoxifen metabolisme
(Master thesis, 2008-06-02)Brystkreft er den vanligste kreftformen blant kvinner i Norge og adjuvant tamoxifenbehandling er vist å øke tilbakefallsfri og total overlevelse. Den interinidividuelle varaiasjonen i effekt og bivirkninger av tamoxifen ... -
Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA
(Journal article; Peer reviewed, 2022)While DNA methylation is established as a major regulator of gene expression in the nucleus, the existence of mitochondrial DNA (mtDNA) methylation remains controversial. Here, we characterized the mtDNA methylation landscape ... -
Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation
(Journal article; Peer reviewed, 2022)Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ... -
Ultraprosessert mat burde være et kostråd: JA
(Journal article, 2023) -
Ultrasensitive Assays for Targeted Breast Cancer Treatment
(Doctoral thesis, 2025-01-23)Den avgjørende rollen til østrogen i østrogenreseptor-positiv (ER+) brystkreft er veletablert, hvor aromatasehemmere som hemmer østrogensyntesen er sentral i behandlingen av brystkreft. Imidlertid er kvantifiseringen av ... -
An ultrasensitive routine LC-MS/MS method for estradiol and estrone in the clinically relevant sub-picomolar range
(Journal article; Peer reviewed, 2020)Background Current analytical routine methods lack the sensitivity to monitor plasma estrogen levels in breast cancer patients treated with aromatase inhibitors. Such monitoring is warranted for premenopausal patients ... -
Ultrasonographic evaluation of disease activity in Crohn’s Disease
(Doctoral thesis, 2020-09-21)Background: Crohn's disease (CD) is a chronic inflammatory disorder in the gastrointestinal (GI) tract, characterized by alternating periods of remission and relapse. Patients’ symptoms do not reliably represent inflammatory ... -
Ultrasonography of major salivary glands in primary and juvenile Sjögren’s syndrome
(Doctoral thesis, 2019-06-07)Background: Primary Sjögrens’s syndrome (pSS) is a systemic autoimmune disease, mainly affecting the salivary and lacrimal glands. Primary SS can also affect the younger population and when it does, the denomination is ... -
Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys
(Journal article; Peer reviewed, 2021-11-29)The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ... -
Ultrasound Detection of Pneumothorax. Development of a porcine pneumothorax model to assess and teach lung ultrasound diagnostics.
(Doctoral thesis, 2013-10-21)Background: Pneumothorax (PTX) is common after blunt chest injury, and failure to diagnose and rapidly treat an enlarging PTX may cause patient death. The anteroposterior supine chest x-ray (CXR) is the least sensitive of ... -
Ultrasound echo-intensity predicts severe Pancreatic affection in cystic fibrosis patients
(Peer reviewed; Journal article, 2015-03-24)Background: Pancreatic destruction affects the majority of patients with cystic fibrosis. We aimed to relate ultrasound findings to exocrine pancreatic function and cystic fibrosis genotype. Methods: Patients with cystic ... -
Ultrasound imaging for assessing functions of the GI tract
(Journal article; Peer reviewed, 2021)Objective: In the following review we outline how ultrasound can be used to measure physiological processes in the gastrointestinal tract. Approach: We have investigated the potential of ultrasound in assessing ... -
Ultrasound in Crohn’s Disease - bowel wall characteristics and perfusion estimates using microbubbles
(Doctoral thesis, 2013-01-18)Crohn’s disease (CD) is a chronic inflammatory bowel disease which often presents early in life and sometimes can be debilitating. The patients need frequent diagnostic work-up to assess disease activity, location, extent ... -
Ultrasound Strain Rate Imaging in Functional Dyspepsia : in-vitro and clinical evaluation
(Doctoral thesis, 2008-06-20)Functional dyspepsia (FD) is a chronic condition that is characterized by abdominal pain or discomfort, nausea, vomiting, early satiation and abdominal fullness. The Rome III classification of functional gastrointestinal ... -
Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells
(Journal article; Peer reviewed, 2020)Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles ... -
Ultrasound-Assisted Endoscopic Removal of Pretibial Cysts Related to Biointerference Screw Degradation
(Journal article; Peer reviewed, 2021)We report on the treatment of cases of painful subcutaneous pretibial cyst due to broken and displaced materials of only partly absorbed bioabsorbable interference screws used for anterior cruciate ligament reconstruction. ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
(Peer reviewed; Journal article, 2018-01-16)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ... -
Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)
(Journal article; Peer reviewed, 2021)Background Solar ultraviolet radiation (UVR) affects the body through pathways that exhibit positive as well as negative health effects such as immunoregulation and vitamin D production. Different vitamin D metabolites ...