Browsing Faculty of Medicine by Author "O'Keeffe, Maria"
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A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice
O'Keeffe, Maria; Oterhals, Åge; Weishaupt, Hrafn; Leh, Sabine; Ulvik, Arve; Ueland, Per Magne; Halstensen, Alfred; Marti, Hans Peter; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2023)Purpose The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish ... -
Dietary fish intake increased the concentration of soluble ACE2 in rats: can fish consumption reduce the risk of COVID-19 infection through interception of SARS-CoV-2 by soluble ACE2?
O'Keeffe, Maria; Oterhals, Åge; Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Mellgren, Gunnar; Halstensen, Alfred; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2023)The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells after binding to the membrane-bound receptor angiotensin-converting enzyme 2 (ACE2), but this may be prevented through interception by soluble ... -
Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats
Toto, Benuarda; Refosco, Alice; O'Keeffe, Maria; Barkhald, Øyvind Halås; Brønstad, Aurora Margrethe; Lied, Gülen Arslan; Yadetie, Fekadu; Goksøyr, Anders; Kögel, Tanja; Dierkes, Jutta (Journal article; Peer reviewed, 2022)Microplastic particles are ubiquitous in the environment. However, little is known about their uptake and effects in humans or mammalian model organisms. Here, we studied the effects of pristine polyamide (15–20 µm) and ...