Browsing Faculty of Medicine by Journals "EMBO Molecular Medicine"

Now showing items 1-4 of 4

    • Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways 

      Fack, Fred; Tardito, Saverio; Hochart, Guillaume; Oudin, Anaïs; Zheng, Liang; Fritah, Sabrina; Golebiewska, Anna; Nazarov, Petr; Bernard, Amandine; Hau, Ann-Christin; Keunen, Olivier; Leenders, William P.J.; Lund-Johansen, Morten; Stauber, Jonathan; Gottlieb, Eyal; Bjerkvig, Rolf; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2017)
      Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ...

    • Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations 

      Liang, Xiao; Kristiansen, Cecilie Katrin; Mostafavi, Sepideh; Vatne, Guro H.; Zantingh, Gina; Kianian, Atefeh; Tzoulis, Charalampos; Høyland, Lena Elise; Ziegler, Mathias; Perez, Roberto Megias; Furriol, Jessica; Zhang, Zhuoyuan; Balafkan, Novin; Hong, Yu; Siller, Richard; Sullivan, Gareth; Bindoff, Laurence (Journal article; Peer reviewed, 2020)
      Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using ...

    • Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis 

      Guyon, Joris; Fernandez-Moncada, Ignacio; Larrieu, Claire M; Bouchez, Cyrielle L; Pagano Zottola, Antonio C; Galvis, Johanna; Chouleur, Tiffanie; Burban, Audrey; Joseph, Kevin; Ravi, Vidhya M; Espedal, Heidi; Røsland, Gro Vatne; Daher, Boutaina; Barre, Aurélien; Dartigues, Benjamin; Karkar, Slim; Rudewicz, Justine; Romero-Garmendia, Irati; Klink, Barbara; Grützmann, Konrad; Derieppe, Marie-Alix; Molinié, Thibaut; Obad, Nina; Léon, Céline; Seano, Giorgio; Miletic, Hrvoje; Heiland, Dieter Henrik; Marsicano, Giovanni; Nikolski, Macha; Bjerkvig, Rolf; Bikfalvi, Andreas; Daubon, Thomas (Journal article; Peer reviewed, 2022)
      Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, ...

    • Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma 

      Han, Mingzhi; Wang, Shuai; Yang, Ning; Wang, Xu; Zhao, Wenbo; Sdik Saed, Halala; Daubon, Thomas; Huang, Bin; Chen, Anjing; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2019-11-28)
      Dysregulated cholesterol metabolism is a hallmark of many cancers, including glioblastoma (GBM), but its role in disease progression is not well understood. Here, we identified cholesterol 24‐hydroxylase (CYP46A1), a ...