Blar i Faculty of Medicine på emneord "Tamoxifen"
Viser treff 1-4 av 4
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A randomized phase II pre-surgical trial of weekly low-dose tamoxifen versus raloxifene versus placebo in premenopausal women with estrogen receptor positive breast cancer
(Peer reviewed; Journal article, 2013-06-20)Introduction: We previously demonstrated that 1 or 5 mg per day of tamoxifen (T) given for four weeks before surgery reduces Ki-67 in breast cancer (BC) patients to the same extent as the standard 20 mg/d. Given the long ... -
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients
(Peer reviewed; Journal article, 2017-11-28)Background: Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in patients using adjuvant tamoxifen. Direct measurement ... -
Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer
(Peer reviewed; Journal article, 2012-06-15)Background: Steroid receptor coactivators (SRCs) may modulate estrogen receptor (ER) activity and the response to endocrine treatment in breast cancer, in part through interaction with growth factor receptor signaling ... -
UGT1A4 og UGT2B15 enkeltnukleotidpolymorfismer. Etablering av real time PCR metoder og betydning for tamoxifen metabolisme
(Master thesis, 2008-06-02)Brystkreft er den vanligste kreftformen blant kvinner i Norge og adjuvant tamoxifenbehandling er vist å øke tilbakefallsfri og total overlevelse. Den interinidividuelle varaiasjonen i effekt og bivirkninger av tamoxifen ...