Now showing items 242-261 of 621

    • G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury 

      Lyu, Chuang; Lyu, Gong-Wei; Mulder, Jan; Martinez, Aurora; Shi, Tie-Jun (Journal article; Peer reviewed, 2020)
      Background: G protein-gated inwardly rectifying potassium (GIRK) channels are involved in the regulation of neuronal excitability. Four GIRK subunits (GIRK1-4) are expressed in rat dorsal root ganglia (DRGs). Recently, we ...
    • GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production 

      Mahootchi, Elaheh; Homaei, Selina Cannon; Kleppe, Rune; Winge, Ingeborg; Hegvik, Tor-Arne; Perez, Roberto Megias; Totland, Christian; Mogavero, Floriana; Baumann, Anne; Glennon, Jeffrey Colm; Miletic, Hrvoje; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2020)
      Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neuromodulators. However, their biosynthetic routes and therapeutic potential are still being debated. This ...
    • Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model 

      Skeie, Bente Sandvei; Wang, Jian; Dodoo, Ernest; Heggdal, Jan Ingemann; Grønli, Janne; Sleire, Linda; Bragstad, Sidsel Marit; Ganz, Jeremy Christopher; Chekenya, Martha; Mørk, Sverre; Pedersen, Paal-Henning; Enger, Per Øyvind (Peer reviewed; Journal article, 2013)
      Object. Gamma knife surgery (GKS) may be used for recurring glioblastomas (GBMs). However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of ...
    • Gender Differences in Psychiatric Comorbidity: Population-based study of 40,000 Adults with Attention-Deficit Hyperactivity Disorder 

      Solberg, Berit Skretting; Halmøy, Anne; Engeland, Anders; Igland, Jannicke; Haavik, Jan; Klungsøyr, Kari (Peer reviewed; Journal article, 2017-12-21)
      OBJECTIVE: We aimed at determining whether gender modified associations between ADHD and psychiatric comorbidities in adults. METHOD: We identified adults with ADHD by linking Norwegian national registries and compared ...
    • Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation 

      Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2012-01-17)
      Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene ...
    • Gene-Environment Interactions in Attention-Deficit/Hyperactivity Disorder Symptom Dimensions: The Role of Unhealthy Food Habits 

      Li, Lin; Taylor, Mark J; Bälter, Katarina; xie, tian; Solberg, Berit Skretting; Haavik, Jan; Arias-Vásquez, Alejandro; Hartman, Catharina A; Larsson, Henrik (Journal article; Peer reviewed, 2021)
      Background: Dietary habits were investigated as environmental risk factors for Attention-Deficit/Hyperactivity Disorder (ADHD). However, no previous studies explored the effects of dietary factors on modifying the role of ...
    • Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase 

      Alam, Jahedul; Musiime, Moses; Romaine, Andreas; Sawant, Mugdha; Melleby, Arne Olav; Lu, Ning; Eckes, Beate; Christensen, Geir; Gullberg, Donald (Journal article; Peer reviewed, 2020)
      Cell-specific expression of genes offers the possibility to use their promoters to drive expression of Cre-recombinase, thereby allowing for detailed expression analysis using reporter gene systems, cell lineage tracing, ...
    • Genetic association study of childhood aggression across raters, instruments, and age 

      Ip, Hill F.; van der Laan, Camiel M.; Krapohl, Eva M. L.; Brikell, Isabell; Sánchez-Mora, Cristina; Nolte, Ilja M.; Pourcain, Beate St; Bolhuis, Koen; Palviainen, Teemu; Zafarmand, Hadi; Colodro-Conde, Lucía; Gordon, Scott; Zayats, Tetyana; Aliev, Fazil; Jiang, Chang; Wang, Carol A.; Saunders, Gretchen; Karhunen, Ville; Hammerschlag, Anke R.; Adkins, Daniel E.; Border, Richard; Peterson, Roseann E.; Prinz, Joseph A.; Thiering, Elisabeth; Seppälä, Iikka; Vilor-Tejedor, Natàlia; Ahluwalia, Tarunveer S.; Day, Felix R.; Hottenga, Jouke-Jan; Allegrini, Andrea G.; Rimfeld, Kaili; Chen, Qi; Yi, Lu; Martin, Joanna; Soler Artigas, Marìa; Rovira, Paula; Bosch, Rosa; Español, Gemma; Ramos-Quiroga, Josep Antonio; Neumann, Alexander; Haavik, Jan; Harris, Jennifer Ruth; Helgeland, Øyvind; Johansson, Stefan; Knudsen, Gun Peggy Strømstad; Njølstad, Pål Rasmus; Havdahl, Alexandra; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Boomsma, Dorret I. (Journal article; Peer reviewed, 2021)
      Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from ...
    • Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder 

      Jacobsen, Kaya Kvarme; Nievergelt, Caroline M.; Zayats, Tetyana; Greenwood, Tifany A.; Anttila, Verneri; Akiskal, Hagop Souren; Haavik, Jan; Fasmer, Ole Bernt; Kelsoe, John R.; Johansson, Stefan; Ødegaard, Ketil Joachim (Peer reviewed; Journal article, 2015-10-12)
      Background. Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background ...
    • Genome-wide analysis of attention deficit hyperactivity disorder in Norway 

      Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (Peer reviewed; Journal article, 2015-04-13)
      Background Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
    • Glioblastoma organoids: pre-clinical applications and challenges in the context of immunotherapy 

      Klein, Eliane; Hau, Ann-Christin; Oudin, Anaïs; Golebiewska, Anna; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-12-08)
      Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall survival is roughly over a year. New therapeutic ...
    • Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes 

      Stieber, Daniel; Golebiewska, Anna; Evers, Lisa; Lenkiewicz, Elizabeth; Brons, Nicolas H.C.; Nicot, Nathalie; Oudin, Anaïs; Bougnaud, Sébastien; Hertel, Frank; Bjerkvig, Rolf; Vallar, Laurent; Barrett, Michael T.; Niclou, Simone P. (Peer reviewed; Journal article, 2014-02)
      Glioblastoma (GBM) is known to be a heterogeneous disease; however, the genetic composition of the cells within a given tumour is only poorly explored. In the advent of personalised medicine the understanding of intra-tumoural ...
    • Glioblastomas with primitive neuronal component harbor a distinct methylation and copy‑number profle with inactivation of TP53, PTEN, and RB1 

      Suwala, Abigail K.; Stichel, Damian; Schrimpf, Daniel; Maas, Sybren L. N.; Sill, Martin; Dohmen, Hildegard; Banan, Rouzbeh; Reinhardt, Annekathrin; Sievers, Philipp; Hinz, Felix; Blattner-Johnson, Mirjam; Hartmann, Christian; Schweizer, Leonille; Boldt, Henning B.; Kristensen, Bjarne Winther; Schittenhelm, Jens; Wood, Matthew D.; Chotar, Guillaume; Bjerkvig, Rolf; Das, Anirban; Tabori, Uri; Hasselblatt, Martin; Korshunov, Andrey; Abdullaev, Zied; Quezado, Martha; Aldape, Kenneth; Harter, Patrick N.; Snuderl, Matija; Hench, Jürgen; Frank, Stephan; Acker, Till; Brandner, Sebastian; Winkler, Frank; Wesseling, Pieter; Pfister, Stefan M.; Reuss, David E.; Wick, Wolfgang; von Deimling, Andreas; Jones, David T. W.; Sahm, Felix (Journal article; Peer reviewed, 2021)
      Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these ...
    • GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation 

      Gozdz, Agata; Nikolaienko, Oleksii; Urbanska, Malgorzata; Cymerman, Iwona; Sitkiewicz, Ewa; Blazejczyk, Magdalena; Dadlez, Michal; Bramham, Clive R.; Jaworski, Jacek (Peer reviewed; Journal article, 2017-06-16)
      The selective and neuronal activity-dependent degradation of synaptic proteins appears to be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which ...
    • HAMLET forms annular oligomers when deposited with phoshpolipid monolayers 

      Baumann, Anne; Gjerde, Anja Underhaug; Ying, Ming; Svanborg, Catharina; Holmsen, Holm A.; Glomm, Wilhelm; Martinez, Aurora; Halskau, Øyvind (Peer reviewed; Journal article, 2012-04)
      Recently, the anticancer activity of human α-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive ...
    • HAMLET interacts with lipid membranes and perturbs their structure and integrity 

      Mossberg, Ann-Kristin; Puchades, Maja; Halskau, Øyvind; Baumann, Anne; Lanekoff, Ingela; Chao, Yinxia; Martinez, Aurora; Svanborg, Catharina; Karlsson, Roger (Peer reviewed; Journal article, 2010-01-23)
      Background Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal ...
    • Health-related quality of life in elderly patients hospitalized with chronic heart failure 

      Erceg, Predrag; Despotovic, Nebosja; Milosevic, Drogoslav P.; Soldatovic, Ivan; Zdravkovic, Sanja; Tomic, Snezana; Markovic, Ivana; Mihajlovic, Gordana; Brajovic, Milan D.; Bojovic, Ognjen; Potic, Bojana; Davidovic, Mladen (Peer reviewed; Journal article, 2013-11-15)
      Background: Chronic heart failure is a very common condition in the elderly, characterized not only by high mortality rates, but also by a strong impact on health-related quality of life (HRQOL). Previous studies of HRQOL ...
    • Healthy kidney segmentation in the dce-mr images using a convolutional neural network and temporal signal characteristics 

      Klepaczko, Artur; Eikefjord, Eli Nina; Lundervold, Arvid (Journal article; Peer reviewed, 2021)
      Quantification of renal perfusion based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) requires determination of signal intensity time courses in the region of renal parenchyma. Thus, selection of voxels ...
    • The Heart and a Fibrotic Interstitium 

      Sagvaag, Vivian (Master thesis, 2009-05-29)
      Several acute and chronic diseases disposes for myocardial oedema and fibrosis, leading to impaired cardiac function, presumably as a result of an increased chamber stiffness. Mechanisms and adverse effects of both oedema ...
    • Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines 

      Acuña-Hinrichsen, Francisca; Covarrubias-Pinto, Adriana; Ishizuka, Yuta; Stolzenbach, María Francisca; Martin, Carolina; Salazar, Paula; Castro, Maite A.; Bramham, Clive Raymond Evjen; Otth, Carola (Journal article; Peer reviewed, 2021)
      Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. ...