Browsing Department of Biomedicine by Title
Now showing items 567-586 of 761
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Quality indicators and early adverse in surgery for atypical meningiomas: A 16-year single centre study and systematic review of the literature
(Journal article; Peer reviewed, 2023)Introduction Atypical meningiomas represent approximately 20% of all intracranial meningiomas and are characterized by distinct histopathological criteria and an increased risk of postoperative recurrence. Recently, ... -
Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood
(Peer reviewed; Journal article, 2014-12)Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. ... -
Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism
(Peer reviewed; Journal article, 2016-08-05)Background: Methylmecury (MeHg) is a widely distributed environmental pollutant with considerable risk to both human health and wildlife. To gain better insight into the underlying mechanisms of MeHg-mediated toxicity, we ... -
Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development
(Journal article; Peer reviewed, 2022)Background Tandem mass tag spectrometry (TMT labeling-LC-MS/MS) was utilized to examine the global proteomes of Atlantic halibut eggs at the 1-cell-stage post fertilization. Comparisons were made between eggs judged to ... -
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
(Peer reviewed; Journal article, 2019-05-08)Background Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. However, T cells play a central role in the pathogenesis by crossing the blood–brain-barrier, leading to inflammation ... -
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls
(Journal article; Peer reviewed, 2022-07-05)Background: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4+ T cells are pivotal ... -
The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity
(Journal article; Peer reviewed, 2019)Tyrosine hydroxylase (TH) is a multi-domain, homo-oligomeric enzyme that catalyses the rate-limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of human TH are associated with a recessive ... -
A randomized double blind comparison of short-term duodenally administrated whale and seal blubber oils in patients with inflammatory bowel disease and joint pain
(Peer reviewed; Journal article, 2009)Compared with soy oil, 10 days treatment with seal oil (SO), 10 mL×3 daily, self-administrated through a nasoduodenal feeding tube, relieves joint pain in patients with inflammatory bowel disease (IBD). This randomized, ... -
Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer.
(Peer reviewed; Journal article, 2014-12)Background: Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells ... -
Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity
(Peer reviewed; Journal article, 2019)The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central ... -
A rat model of radiation injury in the mandibular area
(Peer reviewed; Journal article, 2015-06-09)Background Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. Injuries to the surrounding ... -
Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of Annexin A2
(Peer reviewed; Journal article, 2015-01-15)Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form ... -
Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma.
(Peer reviewed; Journal article, 2019-11-28)Proteolipid protein 2 (PLP2) is an integral ion channel membrane protein of the endoplasmic reticulum. The protein has been shown to be highly expressed in many cancer types, but its importance in glioma progression is ... -
Reduced Granulation Tissue and Wound Strength in the Absence of α11β1 Integrin
(Peer reviewed; Journal article, 2015-12-08)Previous wound healing studies have failed to define a role for either α1β1 or α2β1 integrin in fibroblast-mediated wound contraction, suggesting the involvement of another collagen receptor in this process. Our previous ... -
Reduced Joint Pain after Short-term Duodenal Administration of Seal Oil in Patients with Inflammatory Bowel Disease: Comparison with Soy Oil
(Peer reviewed; Journal article, 2004)Background: Rheumatic joint pain is a common extraintestinal complication of inflammatory bowel disease (IBD). Because the high ratio of n-6 to n-3 fatty acids (FAs) of the Western diet might promote rheumatic disorders, ... -
Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
(Journal article; Peer reviewed, 2022)Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12–15 months. In addition to highly proliferative and invasive properties, GB cells show ... -
Regulation and function of tumor suppressor p53 isoforms beta and gamma in Acute Myeloid Leukemia
(Master thesis, 2013-06-01)Research has proposed that the C-terminal truncated p53 isoforms beta and gamma enhance chemosensitivity in p53(null) cancer cell lines. Their high expression in acute myeloid leukemia (AML) patients correlates positively ... -
Regulation and quantification of cellular mitochondrial morphology and content
(Peer reviewed; Journal article, 2014)Mitochondria play a key role in signal transduction, redox homeostasis and cell survival, which extends far beyond their classical functioning in ATP production and energy metabolism. In living cells, mitochondrial content ... -
Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways
(Peer reviewed; Journal article, 2014-03-11)Background: Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are unclear. ...