• Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin 

      Snaidero, Nicolas; Velte, Caroline; Myllykoski, Matti; Raasakka, Arne; Ignatev, Alexander; Werner, Hauke B.; Erwig, Michelle S.; Möbius, Wiebke; Kursula, Petri; Nave, Klaus-Armin; Simons, Mikael (Peer reviewed; Journal article, 2017-01)
      The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable ...
    • Antibodies raised against aldehyde-fixed antigens improve sensitivity for postembedding electron microscopy 

      Hussain, Suleman; Fredriksen, Irene; Ringsevjen, Håvard; Kavalali, Ege T.; Davanger, Svend (Peer reviewed; Journal article, 2019)
      Background: Antibodies are one of the most important tools in biological research. High specificity and sensitivity of antibodies are crucial to obtain reliable results. Tissue fixed with glutaraldehyde (GA) is commonly ...
    • Apicomplexan actin polymerization depends on nucleation 

      Kumpula, Esa-Pekka; Pires, Isa; Lasiwa, Davki; Piirainen, Henni; Bergmann, Ulrich; Vahokoski, Juha; Kursula, Inari (Peer reviewed; Journal article, 2017-09-22)
      Filamentous actin is critical for apicomplexan motility and host cell invasion. Yet, parasite actin filaments are short and unstable. Their kinetic characterization has been hampered by the lack of robust quantitative ...
    • The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity 

      Oftedal, Linn; Skjærven, Kaja H.; Coyne, Rosie T.; Edvardsen, Bente; Rohrlack, Thomas; Skulberg, Olav M.; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2010-08-06)
      Cyanobacteria (83 strains and seven natural populations) were screened for content of apoptosis (cell death)-inducing activity towards neoplastic cells of the immune (jurkat acute T-cell lymphoma) and hematopoetic (acute ...
    • Arc interacts with the integral endoplasmic reticulum protein, calnexin 

      Myrum, Craig; Soule, Jonathan; Bittins, Margarethe; Cavagnini, Kyle; Goff, Kevin; Ziemek, Silje Karina; Eriksen, Maria Steene; Patil, Sudarshan; Szum, Adrian; Nair Raveendran, Rajeevkumar; Bramham, Clive R. (Peer reviewed; Journal article, 2017-09-20)
      Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum ...
    • Arc is a flexible modular protein capable of reversible self-oligomerization 

      Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Peer reviewed; Journal article, 2015)
      The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ...
    • The Arc of synaptic memory 

      Bramham, Clive R.; Alme, Maria N.; Bittins, Margarethe; Kuipers, Sjoukje D.; Nair, Rajeevkumar R.; Pai, Balagopal; Panja, Debabrata; Schubert, Manja; Soule, Jonathan; Tiron, Adrian; Wibrand, Karin (Peer reviewed; Journal article, 2010)
      The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. ...
    • Assembly and Cellular Exit of Coronaviruses: Hijacking an Unconventional Secretory Pathway from the Pre-Golgi Intermediate Compartment via the Golgi Ribbon to the Extracellular Space 

      Saraste, Jaakko; Prydz, Kristian (Journal article; Peer reviewed, 2021)
      Coronaviruses (CoVs) assemble by budding into the lumen of the intermediate compartment (IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the IC as their intracellular site of assembly ...
    • Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study 

      Hegvik, Tor-Arne; Instanes, Johanne Telnes; Haavik, Jan; Klungsøyr, Kari; Engeland, Anders (Peer reviewed; Journal article, 2018-05)
      Several studies have demonstrated associations between neuropsychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD), and the immune system, including autoimmune diseases. Since ADHD and many autoimmune ...
    • Atomic view into plasmodium actin polymerization, ATP hydrolysis, and fragmentation 

      Kumpula, Esa-Pekka; Lopez Moreno, Andrea Johana; Tajedin, Leila; Han, Huijong; Kursula, Inari (Peer reviewed; Journal article, 2019)
      Plasmodium actins form very short filaments and have a noncanonical link between ATP hydrolysis and polymerization. Long filaments are detrimental to the parasites, but the structural factors constraining Plasmodium ...
    • Attention Network Test in adults with ADHD - the impact of affective fluctuations 

      Lundervold, Astri Johansen; Adólfsdóttir, Steinunn; Halleland, Helene Barone; Halmøy, Anne; Plessen, Kerstin von; Haavik, Jan (Peer reviewed; Journal article, 2011-07-27)
      Background: The Attention Network Test (ANT) generates measures of different aspects of attention/executive function. In the present study we investigated whether adults with ADHD performed different from controls on ...
    • Attention-deficit/hyperactivity disorder and smoking habits in pregnant women 

      Anderson, Anneli; Hegvik, Tor-Arne; Chen, Qi; Kvalvik, Liv Grimstvedt; Almqvist, Catarina; D'Onofrio, Brian M.; Hartman, Catharina A; Klungsøyr, Kari; Haavik, Jan; Tuvblad, Catherine; Larsson, Henrik (Journal article; Peer reviewed, 2020)
      Background Attention-deficit/hyperactivity disorder (ADHD) has been associated with an increased risk of tobacco smoking, and more difficulties with smoking cessation compared to non-ADHD individuals. Women with ADHD may ...
    • Attention-deficit/hyperactivity disorder symptoms and dietary habits in adulthood: A large population-based twin study in Sweden 

      Li, Lin; Taylor, Mark J.; Bälter, Katarina; Kuja-Halkola, Ralf; Chen, Qi; Hegvik, Tor-Arne; Tate, Ashley E.; Chang, Zheng; Arias-Vasquez, Alejandro; Hartman, Catharina A.; Larsson, Henrik (Journal article; Peer reviewed, 2020)
      Associations between adult attention-deficit/hyperactivity disorder (ADHD) symptoms and dietary habits have not been well established and the underlying mechanisms remain unclear. We explored these associations using a ...
    • Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties 

      Nikolaisen, Julie; Nilsson, Linn Iren Hodneland; Pettersen, Ina Katrine Nitschke; Willems, Peter H. G. M.; Lorens, James B.; Koopman, Werner J. H.; Tronstad, Karl Johan (Peer reviewed; Journal article, 2014-07-02)
      Mitochondrial morphology and function are coupled in healthy cells, during pathological conditions and (adaptation to) endogenous and exogenous stress. In this sense mitochondrial shape can range from small globular ...
    • AXL is a driver of stemness in normal mammary gland and breast cancer 

      Engelsen, Agnete; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien; Vatter, Fanny A. Pelissier; Tiron, Crina Elena; Villadsen, René; Miyano, Masaru; Lotsberg, Maria Lie; Madeleine, Noëlly; Panahandeh, Pouda; Dhakal, Sushil; Tan, Tuan Zea; Peters, Stacey D'Mello; Grøndal, Sturla Magnus; Aziz, Sura Mohammed; Nord, Silje; Herfindal, Lars; Stampfer, Martha R.; Sørlie, Therese; Brekken, Rolf A; Straume, Oddbjørn; Halberg, Nils; Gausdal, Gro; Thiery, Jean Paul; Akslen, Lars A.; Petersen, Ole W.; LaBarge, Mark A.; Lorens, James (Journal article; Peer reviewed, 2020)
      The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of ...
    • AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells 

      Lotsberg, Maria Lie; Wnuk-Lipinska, Katarzyna; Terry, Stéphane; Tan, Tuan Zea; Lu, Ning; Trachsel-Moncho, Laura; Røsland, Gro Vatne; Siraji, Muntequa Ishtiaq; Hellesøy, Monica; Rayford, Austin James; Jacobsen, Kirstine; Ditzel, Henrik J; Vintermyr, Olav Karsten; Bivona, Trever G; Minna, John; Brekken, Rolf A; Baguley, Bruce; Micklem, David; Akslen, Lars A.; Gausdal, Gro; Simonsen, Anne; Thiery, Jean Paul; Chouaib, Salem; Lorens, James; Engelsen, Agnete (Journal article; Peer reviewed, 2020)
      Introduction Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine ...
    • B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion 

      Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Peer reviewed; Journal article, 2015-04)
      Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ...
    • BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis 

      Kuipers, Sjoukje; Trentani, Andrea; Tiron, Adrian; Mao, Xiaosong; Kuhl, Dietmar; Bramham, Clive R. (Peer reviewed; Journal article, 2016-02-18)
      Adult neurogenesis in the hippocampus is a remarkable phenomenon involved in various aspects of learning and memory as well as disease pathophysiology. Brain-derived neurotrophic factor (BDNF) represents a major player in ...
    • The Benefit of Large Neutral Amino Acid Supplementation to a Liberalized Phenylalanine-Restricted Diet in Adult Phenylketonuria Patients: Evidence from Adult Pah-Enu2 Mice 

      Van Vliet, Danique; van der Goot, Els; van Ginkel, Wiggert G; van Faassen, Martijn H J R; de Blaauw, Pim; Kema, Ido P.; Martinez, Aurora; Heiner-Fokkema, M Rebecca; van der Zee, Eddy A; van Spronsen, Francjan J. (Peer reviewed; Journal article, 2019-09-19)
      Many phenylketonuria (PKU) patients cannot adhere to the severe dietary restrictions as advised by the European PKU guidelines, which can be accompanied by aggravated neuropsychological impairments that, at least in part, ...
    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Peer reviewed; Journal article, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...