Blar i Department of Biomedicine på tittel
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Exploring and exploiting the potential of pelvic IMRT to spare the bowel
(Doctoral thesis, 2011-10-28) -
Exploring the anti-leukemic effect of the combination treatment with Valproic acid, Lonidamine and Mycophenolate mofetil in acute myeloid leukemia
(Master thesis, 2015-06-01)An accumulation of immature myeloid progenitor cells at the expense of normal hematopoietic precursors characterizes the aggressive heterogeneous cancer acute myeloid leukemia (AML). It affects the bone marrow and peripheral ... -
Exploring the human plasma proteome for humoral mediators of remote ischemic preconditioning - A word of caution
(Peer reviewed; Journal article, 2014-10-15)Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has ... -
Exploring the potential of public proteomics data
(Peer reviewed; Journal article, 2016)In a global effort for scientific transparency, it has become feasible and good practice to share experimental data supporting novel findings. Consequently, the amount of publicly available MS‐based proteomics data has ... -
Expression and effects of IL-1 and TNF-α in different experimental models of dental inflammation
(Doctoral thesis, 2006-07-04) -
Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury
(Journal article; Peer reviewed, 2020)FRMD6, a member of the group of FERM-domain proteins, is involved both in communication between cells, interactions with extracellular matrix, cellular apoptotic and regenerative mechanisms. FRMD6 was first discovered in ... -
Expression of biomarkers (p53, transforming growth factor alpha, epidermal growth factor receptor, c-erbB-2/neu and the proliferative cell nuclear antigen) in oropharyngeal squamous cell carcinomas
(Peer reviewed; Journal article, 1999)Using immunohistochemistry, expression of p53, transforming growth factor-alpha (TGF-α), epidermal growth factor receptor (EGFR), c-erbB-2/neu and proliferating cell nuclear antigen (PCNA) was examined in 26 fresh frozen ... -
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
(Peer reviewed; Journal article, 2011-08-24)Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ... -
EXT proteins: Role in heparan sulfate Assembly and in Tumor biology
(Doctoral thesis, 2018-08-24)The exostosin family of proteins is necessary for heparan sulfate biosynthesis. Heparan sulfate polysaccharide biosynthesis is one of several different forms of proteinglycosylation processes that take place in the Golgi ... -
The extostosin family: Proteins with many functions
(Peer reviewed; Journal article, 2014-04)Heparan sulfates are complex sulfated molecules found in abundance at cell surfaces and in the extracellular matrix. They bind to and influence the activity of a variety of molecules like growth factors, proteases and ... -
Extrasynaptic NMDA receptors on rod pathway amacrine cells: molecular composition, activation, and signaling
(Peer reviewed; Journal article, 2019)In the rod pathway of the mammalian retina, axon terminals of glutamatergic rod bipolar cells are presynaptic to AII and A17 amacrine cells in the inner plexiform layer. Recent evidence suggests that both amacrines express ... -
Familial co-aggregation of attention-deficit/ hyperactivity disorder and autoimmune diseases: a cohort study based on Swedish population-wide registers
(Journal article; Peer reviewed, 2021)Background Attention-deficit/hyperactivity disorder (ADHD) has been associated with several autoimmune diseases (AD), both within individuals and across relatives, implying common underlying genetic or environmental factors ... -
Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats
(Peer reviewed; Journal article, 2017-10-04)Better understanding of the physiological mechanisms and neurological symptoms involved in the development of decompression sickness could contribute to improvements of diving procedures. The main objective of the present ... -
Fibroblast EXT1-Levels Influence Tumor Cell Proliferation and Migration in Composite Spheroids
(Peer reviewed; Journal article, 2012-07-25)Background: Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan ... -
Fibroblast α11β1 Integrin Regulates Tensional Homeostasis in Fibroblast/A549 Carcinoma Heterospheroids
(Peer reviewed; Journal article, 2014-07-30)We have previously shown that fibroblast expression of α11β1 integrin stimulates A549 carcinoma cell growth in a xenograft tumor model. To understand the molecular mechanisms whereby a collagen receptor on fibroblast can ... -
Filamin A binds to CCR2B and regulates its internalization
(Peer reviewed; Journal article, 2010-08-17)The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory ... -
Filamin A-Hinge Region 1-EGFP: A Novel Tool for Tracking the Cellular Functions of Filamin A in Real-Time
(Peer reviewed; Journal article, 2012-08-01)Background: Filamin A (FLNa) is an actin-crosslinking protein necessary for stabilizing the cell surface, organizing protrusive activity and for promoting efficient cellular translocation. Recently, our group demonstrated ... -
The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1
(Journal article; Peer reviewed, 2022)Actin is a hallmark protein of the cytoskeleton in eukaryotic cells, affecting a range of cellular functions. Actin dynamics is regulated through a myriad of actin-binding proteins and post-translational modifications. The ... -
Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease
(Journal article; Peer reviewed, 2020)Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, ... -
Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets
(Peer reviewed; Journal article, 2014-06-21)Background: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate ...