Browsing Department of Biomedicine by Title

Now showing items 224-243 of 708

    • Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE 

      Jacobsen, Kaya Kvarme; Kleppe, Rune; Johansson, Stefan; Zayats, Tetyana; Haavik, Jan (Peer reviewed; Journal article, 2015-09)
      Monoamines critically modulate neurophysiological functions affected in several neuropsychiatric disorders. We therefore examined genes encoding key enzymes of catecholamine and serotonin biosynthesis (tyrosine and tryptophan ...

    • Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC 

      Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit; Helwa, Reham; Tan, Tuan Zea; Lotsberg, Maria Lie; Pettersen, Ina Katrine Nitschke; Berg, Anna; Kindt, Charlotte; Hoel, Fredrik; Jacobsen, Kristine; Arason, Ari Jon; Engelsen, Agnete; Ditzel, Henrik J.; Lønning, Per Eystein; Krakstad, Camilla; Thiery, Jean Paul; Lorens, James; Knappskog, Stian; Tronstad, Karl Johan (Peer reviewed; Journal article, 2019-06-01)
      Background: Epithelial to mesenchymal transition (EMT) is a well-characterized process of cell plasticity that may involve metabolic rewiring. In cancer, EMT is associated with malignant progression, tumor heterogeneity, ...

    • Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells 

      Kropotov, Andrey; Kulikova, Veronika; Nerinovski, Kirill; Yakimov, Alexander; Svetlova, Maria; Solovjeva, Ljudmila; Sudnitsyna, Julia; Migaud, Marie E.; Khodorkovskiy, Mikhail; Ziegler, Mathias; Nikiforov, Andrey (Journal article; Peer reviewed, 2021)
      Nicotinamide riboside (NR), a new form of vitamin B3, is an effective precursor of nicotinamide adenine dinucleotide (NAD+) in human and animal cells. The introduction of NR into the body effectively increases the level ...

    • Esmolol added in repeated, cold, oxygenated blood cardioplegia improves myocardial function after cardiopulmonary bypass 

      Dahle, Geir Olav; Salminen, Pirjo-Riitta; Moen, Christian Arvei; Eliassen, Finn; Jonassen, Anne K.; Haaverstad, Rune; Matre, Knut; Grong, Ketil (Peer reviewed; Journal article, 2015-06)
      Objective: This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design: A block-randomized, blinded ...

    • Essential Features and Use Cases of the Cerebrospinal Fluid Proteome Resource (CSF-PR) 

      Guldbrandsen, Astrid; Farag, Yehia Mohamed Mokhtar; Lereim, Ragnhild Reehorst; Berven, Frode; Barsnes, Harald (Peer reviewed; Journal article, 2019)
      Every year, a large number of published studies present biomarkers for various neurological disorders. Many of these studies are based on mass spectrometry proteomics data and describe comparison of the abundance of proteins ...

    • EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology 

      Brennecke, Philip; Rasina, Dace; Aubi Catevilla, Oscar; Herzog, Katja; Landskron, Johannes; Cautain, Bastien; Vicente, Francisca; Quintana, Jordi; Mestres, Jordi; Stechmann, Bahne; Ellinger, Bernhard; Brea, Jose; Kolanowski, Jacek L.; Pilarski, Radosław; Orzáez, Mar; Pineda-Lucena, Antonio; Laraia, Luca; Nami, Faranak; Zielenkiewicz, Piotr; Paruch, Kamil; Hansen, Espen; von Kries, Jens P.; Neuenschwander, Martin; Specker, Edgar; Bartunek, Petr; Šímová, Šárka; Leśnikowski, Zbigniew; Krauss, Stefan; Lehtiö, Lari; Bilitewski, Ursula; Brönstrup, Mark; Tasken, Kjetil; Jirgensons, Aigars; Lickert, Heiko; Clausen, Mads H.; Andersen, Jeanette hammer; Vicent, Maria J.; Genilloud, Olga; Martinez, Aurora; Nazaré, Marc; Fecke, Wolfgang; Gribbon, Philip (Peer reviewed; Journal article, 2019)
      Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates. To facilitate such discoveries, the European Research ...

    • Evaluating Extracellular Matrix influence on adherent cell signaling by Cold Trypsin Phosphorylation-specific Flow Cytometry 

      Abrahamsen, Iren; Lorens, James B. (Peer reviewed; Journal article, 2013-08-19)
      Background: Tissue microenvironments comprise different extracellular matrix (ECM) proteins that regulate cellular responsiveness to growth factors. In vitro culture of adherent cells on ECM-coated substrata is commonly ...

    • Evaluation of Prebiotic and Probiotic Effects on the Intestinal Gut Microbiota and Histology of Atlantic salmon (Salmo salar L.) 

      Kristiansen, Mads; Merrifield, Daniel L.; Gonzalez Vecino, Jose L.; Myklebust, Reidar; Ringø, Einar (Peer reviewed; Journal article, 2011)
      In the present study the impact on gut microbiology and indigenous gut histology of Atlantic salmon (Salmo salar L.) was investigated following feeding of a control and a prebiotic (EWOS prebiosal®) diet and ex vivo exposure ...

    • Event-related-potential (ERP) correlates of performance monitoring in adults with attention-deficit hyperactivity disorder (ADHD) 

      Marquardt, Lynn Anne; Eichele, Heike; Lundervold, Astri; Haavik, Jan; Eichele, Tom (Peer reviewed; Journal article, 2018-04-11)
      Introduction: Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental disorders in children and tends to persist into adulthood. Evidence from neuropsychological, neuroimaging, and ...

    • Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis 

      Zhang-James, Yanli; Helminen, Emily C.; Liu, Jinru; Busatto, Geraldo F.; Calvo, Anna; Cercignani, Mara; Chaim-Avancini, Tiffany M.; Gabel, Matt C.; Harrison, Neil A.; Lazaro, Luisa; Lera-Miguel, Sara; Louza, Mario R.; Nicolau, Rosa; Rosa, Pedro G.; Schulte-Rutte, Martin; Zanetti, Marcus V.; Ambrosino, Sara; Asherson, Philip; Banaschewski, Tobias; Baranov, Alexandr; Baumeister, Sarah; Baur-Streubel, Ramona; Bellgrove, Mark A.; Biederman, Joseph; Bralten, Janita; Bramati, Ivanei; Brandeis, Daniel; Brem, Silvia; Buitelaar, Jan K.; Castellanos, Francisco X.; Chantiluke, Kaylita C.; Christakou, Anastasia; Coghill, David; Conzelmann, Annette; Cubillo, Ana; Dale, Anders M.; de Zeeuw, Patrick; Doyle, Alysa E.; Durston, Sarah; Earl, Eric A.; Epstein, Jeffery N.; Ethofer, Thomas; Fair, Damien A.; Fallgatter, Andreas J.; Frodl, Thomas; Gogberashvili, Tinatin; Haavik, Jan; Hartman, Catharina A.; Heslenfeld, Dirk J.; Hoekstra, Pieter J.; Hohmann, Sarah; Høvik, Marie Farstad; Jahanshad, Neda; Jernigan, Terry L.; Kardatzki, Bernd; Karkashadze, George A.; Kelly, Clare; Kohls, Gregor; Konrad, Kerstin; Kuntsi, Jonna; Lesch, Klaus-Peter; Lundervold, Astri J.; Malpas, Charles B.; Mattos, Paulo; McCarthy, Hazel; Mehta, Mitul A.; Namazova-Baranova, Leyla; Nigg, Joel T.; Novotny, Stephanie E.; O’Gorman Tuura, Ruth L.; Weiss, Eileen Oberwelland; Oosterlaan, Jaap; Oranje, Bob; Paloyelis, Yannis; Pauli, Paul; Plessen, Kerstin J.; Ramos-Quiroga, Josep Antoni; Reif, Andreas; Reneman, Liesbeth; Rubia, Katya; Schrantee, Anouk; Schwarz, Lena; Schweren, Lizanne J.S.; Seitz, Jochen; Shaw, Philip; Silk, Tim J.; Skokauskas, Norbert; Vila, Juan Carlos Soliva; Stevens, Michael C.; Sudre, Gustavo; Tamm, Leanne; Thompson, Paul M.; Tovar-Moll, Fernanda; van Erp, Theo G.M.; Vance, Alasdair; Vilarroya, Oscar; Vives-Gilabert, Yolanda; von Polier, Georg G.; Walitza, Susanne; Yoncheva, Yuliya N.; Ziegler, Georg C.; Franke, Barbara; Hoogman, Martine; Faraone, Stephen (Journal article; Peer reviewed, 2021)
      Attention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms of ADHD into adulthood. Although a large literature implicates structural brain ...

    • Evidence for the role of Rab11-positive recycling endosomes as intermediates in coronavirus egress from epithelial cells 

      Saraste, Jaakko; Enyioko, Mary; Dale, Hege Avsnes; Prydz, Kristian; Machamer, Carolyn (Journal article; Peer reviewed, 2022)
      After their assembly by budding into the lumen of the intermediate compartment (IC) at the endoplasmic reticulum (ER)–Golgi interface, coronaviruses (CoVs) are released from their host cells following a pathway that remains ...

    • Evolution of structure and function in Phenylalanine Hydroxylase. With the regulatory properties in sight 

      Siltberg-Liberles, Jessica (Doctoral thesis, 2008-11-07)
      In the post-genomic era, an idea of how similar the genomes of different species actually are is on the horizon. Less than 10 years ago, the human genome was estimated to encode 100000 genes. That was an overestimation, ...

    • Excitatory and inhibitory signaling in the rod pathway of the retina: Functional properties and activation of synaptic and extrasynaptic receptors 

      Beltrán Matas, Pablo (Doctoral thesis, 2021-01-29)
      The visual system is arguably one of the most complex and studied sensory systems. The processing of visual information starts in the retina, where photoreceptors transduce light stimuli (photons) to electrochemical signals ...

    • Exome sequencing in a child with neurodevelopmental disorder and epilepsy: Variant analysis of the AHNAK2 gene 

      Vinci, Mirella; Kursula, Petri; Greco, Donatella; Elia, Maurizio; Vetri, Luigi; Schepis, Carmelo; Chiavetta, Valeria; Donadio, Serena; Roccella, Michele; Carotenuto, Marco; Romano, Valentino; Calì, Francesco (Journal article; Peer reviewed, 2022)
      Background The AHNAK2 gene encodes a large nucleoprotein expressed in several tissues, including brain, squamous epithelia, smooth muscle, and neuropil. Its role in calcium signaling has been suggested and to date, clear ...

    • Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC 

      Van Damme, Petra; Osberg, Camilla; Jonckheere, Veronique; Glomnes, Nina; Gevaert, Kris; Arnesen, Thomas; Aksnes, Henriette (Journal article; Peer reviewed, 2022)
      N-terminal acetylation is a conserved protein modification among eukaryotes. The yeast Saccharomyces cerevisiae is a valuable model system for studying this modification. The bulk of protein N-terminal acetylation in S. ...

    • Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes? 

      Zayats, Tetyana; Johansson, Stefan; Haavik, Jan (Peer reviewed; Journal article, 2015-10-16)
      Genome-wide association (GWA) studies have shown that many different genetic variants cumulatively contribute to the risk of psychiatric disorders. It has also been demonstrated that various parent-of-origin effects (POE) ...

    • Experimental modeling and novel therapeutic strategies in melanoma brain metastasis 

      Sundstrøm, Terje (Doctoral thesis, 2015-06-09)
      Melanoma patients carry a high risk of developing brain metastases and improvements in survival are still measured in weeks or months. The aim of this thesis was to study the biology of melanoma brain metastasis and find ...

    • An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics 

      Espeland, Ludvik Olai; Georgiou, Charis; Klein, Raphael; Bhukya, Hemalatha; Haug, Bengt Erik; Underhaug, Jarl; Mainkar, Prathama S.; Brenk, Ruth (Journal article; Peer reviewed, 2021)
      FabF (3-oxoacyl-[acyl-carrier-protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from ...

    • Exploiting the potential of commercial digital holographic microscopy by combining it with 3D matrix cell culture assays 

      Hellesvik, Monica; Øye, Hanne; Aksnes, Henriette (Journal article; Peer reviewed, 2020)
      3D cell culture assays are becoming increasingly popular due to their higher resemblance to tissue environment. These provide an increased complexity compared to the growth on 2D surface and therefore allow studies of ...

    • Exploring and exploiting the potential of pelvic IMRT to spare the bowel 

      Hysing, Liv Bolstad (Doctoral thesis, 2011-10-28)