• Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line 

      Raasakka, Arne; Ruskamo, Salla; Kowal, Julia; Barker, Robert; Baumann, Anne; Martel, Anne; Tuusa, Jussi; Myllykoski, Matti; Bürck, Jochen; Ulrich, Anne S.; Stahlberg, Henning; Kursula, Petri (Peer reviewed; Journal article, 2017-07-10)
      Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets ...
    • Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy 

      Åsrud, Kathrine Sivertsen; Pedersen, Line; Aesoy, Reidun; Muwonge, Haruna; Aasebø, Elise; Pettersen, Ina Katrine Nitschke; Herfindal, Lars; Dobie, Ross; Jenkins, Stephen; Berge, Rolf Kristian; Henderson, Neil Cowan; Selheim, Frode; Doskeland, Stein Ove; Bakke, Marit (Peer reviewed; Journal article, 2019-09-24)
      The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ...
    • The microenvironment in human ovarian carcinoma - characterization through proteomic analysis of tissue interstitial fluid 

      Haslene-Hox, Hanne (Doctoral thesis, 2013-10-11)
      The interstitial fluid of tissues and that of tumors in particular, represents the secretome and is thus a valuable source of tissue-specific proteins. The differential expression of proteins that are secreted in tumor ...
    • MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc 

      Wibrand, Karin; Pai, Balagopal; Siripornmongcolchai, Taweeporn; Bittins, Margarethe; Berentsen, Birgitte; Ofte, May Lillian; Weigel, Arwed; Skaftnesmo, Kai Ove; Bramham, Clive R. (Peer reviewed; Journal article, 2012-07-26)
      Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse types of experience-dependent synaptic plasticity and long-term memory in mammals. However, the mechanisms governing Arc-specific ...
    • Mitochondrial DNA depletion in sporadic inclusion body myositis 

      Bhatt, Padmanabh S.; Tzoulis, Charalampos; Balafkan, Novin; Miletic, Hrvoje; Tran, Gia Tuong Thi; Sanaker, Petter Schandl; Bindoff, Laurence (Peer reviewed; Journal article, 2019)
      Sporadic inclusion body myositis (sIBM) is a late onset disorder of unkown aetiology. Mitochondrial changes such as cytochrome oxidase deficient fibres are a well recognised feature and mitochondrial DNA (mtDNA) deletions ...
    • Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins 

      Kleppe, Rune; Ghorbani, Sadaf; Martinez, Aurora; Haavik, Jan (Peer reviewed; Journal article, 2014-01-03)
      The 14-3-3 proteins are important effectors of Ser/Thr phosphorylation in eukaryotic cells. Using mathematical modelling we investigated the roles of these proteins as effectors in signalling pathways that involve ...
    • Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo 

      Vieuille, Christel Marie (Master thesis, 2012-05-30)
      Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ...
    • Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK 

      Deng, Sunbin; Mc Tiernan, Nina; Wei, Xuepeng; Arnesen, Thomas; Marmorstein, Ronen (Journal article; Peer reviewed, 2020-02)
      The human N-terminal acetyltransferase E (NatE) contains NAA10 and NAA50 catalytic, and NAA15 auxiliary subunits and associates with HYPK, a protein with intrinsic NAA10 inhibitory activity. NatE co-translationally acetylates ...
    • Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs 

      Zeltz, Cedric; Orgel, Joseph; Gullberg, Donald (Peer reviewed; Journal article, 2014-08)
      Background: Despite detailed knowledge about the structure and signaling properties of individual collagen receptors, much remains to be learned about how these receptors participate in linking cells to fibrillar collagen ...
    • Molecular structure and function of myelin protein P0 in membrane stacking 

      Raasakka, Arne; Ruskamo, Salla; Kowal, Julia; Han, Huijong; Baumann, Anne; Myllykoski, Matti; Fasano, Anna; Rossano, Rocco; Riccio, Paolo; Bürck, Jochen; Ulrich, Anne S.; Stahlberg, Henning; Kursula, Petri (Peer reviewed; Journal article, 2019)
      Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system, this is partially enabled by myelin ...
    • Monte Carlo vs. Pencil Beam based optimization of stereotactic lung IMRT 

      Sikora, Marcin Pawel; Muzik, Jan; Söhn, Matthias; Weinmann, Martin; Alber, Markus (Peer reviewed; Journal article, 2009-12-12)
      Background: The purpose of the present study is to compare finite size pencil beam (fsPB) and Monte Carlo (MC) based optimization of lung intensity-modulated stereotactic radiotherapy (lung IMSRT). Materials and methods: ...
    • A multi-layer perceptron network for perfusion parameter estimation in DCE-MRI studies of the healthy kidney 

      Klepaczko, Artur; Strzelecki, Michał; Kociołek, Marcin; Eikefjord, Eli Bjøvad; Lundervold, Arvid (Journal article; Peer reviewed, 2020)
      Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an imaging technique which helps in visualizing and quantifying perfusion—one of the most important indicators of an organ’s state. This paper ...
    • Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes 

      Wittig, Dierk; Wang, Xiang; Walter, Cindy; Gerdes, Hans-Hermann; Funk, Richard H. W.; Roehlecke, Cora (Peer reviewed; Journal article, 2012-03-22)
      Background: Tunneling nanotubes (TNTs) may offer a very specific and effective way of intercellular communication. Here we investigated TNTs in the human retinal pigment epithelial (RPE) cell line ARPE-19. Morphology of ...
    • Multi-national Gene Expression Profiling of Oral Squamous Cell Carcinomas. Biological Pathways Regardless of Differences Related to Life-style and Ethnicity 

      Lunde, Mai Lill Suhr (Doctoral thesis, 2012-02-02)
      Oral squamous cell carcinoma (OSCC) is a major health problem in many developing countries, representing more than 25% of all new cancer cases in some countries such as India and Sri Lanka. Cigarette smoking, smokeless ...
    • Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies 

      Keunen, Olivier; Taxt, Torfinn; Grüner, Renate; Lund-Johansen, Morten; Tonn, Joerg-Christian; Pavlin, Tina; Bjerkvig, Rolf; Niclou, Simone P.; Thorsen, Frits Alan (Peer reviewed; Journal article, 2014-09-30)
      The vastmajority ofmalignant gliomas relapse after surgery and standard radio-chemotherapy. Novelmolecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth.While histopathology ...
    • Multimodal Imaging of Physiologic Changes Induced by Anti-Angiogenic Therapy in Glioblastoma 

      Keunen, Olivier (Doctoral thesis, 2014-12-18)
      Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ...
    • Multiphoton excitation microscopy for the reconstructionand analysis of single neuron morphology 

      Hartveit, Espen; Zandt, Bas-Jan; Veruki, Margaret Lin (Neuromethods, Chapter; Peer reviewed, 2019)
      Neurons are the main cellular components of the circuits of the central nervous system (CNS). The dendritic and axonal morphology of individual neurons display marked variability between neurons in different regions of the ...
    • Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin 

      Biedermann, Julia; Preussler, Mathias; Conde, Marina; Peitzsch, Mirko; Richter, Susan; Wiedemuth, Ralf; Abou-El-Ardat, Khalil; Krüger, Alexander; Meinhardt, Mathias; Schackert, Gabriele; Leenders, William P.J.; Herold-Mende, Christel; Niclou, Simone Pierrette; Bjerkvig, Rolf; Eisenhofer, Graeme; Temme, Achim; Seifert, Michael; Kunz-Schughart, Leoni A.; Schröck, Evelin; Klink, Barbara (Peer reviewed; Journal article, 2019-12-16)
      IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), ...
    • Myelin-derived and putative molecular mimic peptides share structural properties in aqueous and membrane-like environments 

      Tuusa, Jussi; Raasakka, Arne; Ruskamo, Salla; Kursula, Petri (Peer reviewed; Journal article, 2017-03-24)
      Background: Despite intense research, the causes of various neurological diseases remain enigmatic to date. A role for viral or bacterial infection and associated molecular mimicry has frequently been suggested in the ...
    • The mzIdentML data standard version 1.2, supporting advances in proteome informatics 

      Vizcaíno, Juan Antonio; Mayer, Gerhard; Perkins, Simon; Barsnes, Harald; Vaudel, Marc; Perez-Riverol, Yasset; Ternent, Tobias; Uszkoreit, Julian; Eisenacher, Martin; Fischer, Lutz; Rappsilber, Juri; Netza, Eugen; Walzer, Mathias; Kohlbacher, Oliver; Leitner, Alexander; Chalkley, Robert J.; Ghali, Fawaz; Martínez-Bartolomé, Salvador; Deutsch, Eric W.; Jones, Andrew R. (Peer reviewed; Journal article, 2017-07-01)
      The first stable version of the Proteomics Standards Initiative mzIdentML open data standard (version 1.1) was published in 2012—capturing the outputs of peptide and protein identification software. In the intervening ...