Blar i Department of Biomedicine på tittel
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Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes
(Peer reviewed; Journal article, 2014-02)Glioblastoma (GBM) is known to be a heterogeneous disease; however, the genetic composition of the cells within a given tumour is only poorly explored. In the advent of personalised medicine the understanding of intra-tumoural ... -
Glioblastomas with primitive neuronal component harbor a distinct methylation and copy‑number profle with inactivation of TP53, PTEN, and RB1
(Journal article; Peer reviewed, 2021)Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these ... -
GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation
(Peer reviewed; Journal article, 2017-06-16)The selective and neuronal activity-dependent degradation of synaptic proteins appears to be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which ... -
HAMLET forms annular oligomers when deposited with phoshpolipid monolayers
(Peer reviewed; Journal article, 2012-04)Recently, the anticancer activity of human α-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive ... -
HAMLET interacts with lipid membranes and perturbs their structure and integrity
(Peer reviewed; Journal article, 2010-01-23)Background Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal ... -
Health-related quality of life in elderly patients hospitalized with chronic heart failure
(Peer reviewed; Journal article, 2013-11-15)Background: Chronic heart failure is a very common condition in the elderly, characterized not only by high mortality rates, but also by a strong impact on health-related quality of life (HRQOL). Previous studies of HRQOL ... -
Healthy kidney segmentation in the dce-mr images using a convolutional neural network and temporal signal characteristics
(Journal article; Peer reviewed, 2021)Quantification of renal perfusion based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) requires determination of signal intensity time courses in the region of renal parenchyma. Thus, selection of voxels ... -
The Heart and a Fibrotic Interstitium
(Master thesis, 2009-05-29)Several acute and chronic diseases disposes for myocardial oedema and fibrosis, leading to impaired cardiac function, presumably as a result of an increased chamber stiffness. Mechanisms and adverse effects of both oedema ... -
Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis
(Journal article; Peer reviewed, 2022)Heparan sulfate (HS), a highly negatively charged glycosaminoglycan, is ubiquitously present in all tissues and also exposed on the surface of mammalian cells. A plethora of molecules such as growth factors, cytokines or ... -
Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines
(Journal article; Peer reviewed, 2021)Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. ... -
HIDEA syndrome is caused by biallelic, pathogenic, rare or founder P4HTM variants impacting the active site or the overall stability of the P4H-TM protein
(Journal article; Peer reviewed, 2022)HIDEA syndrome is caused by biallelic pathogenic variants in P4HTM. The phenotype is characterized by muscular and central hypotonia, hypoventilation including obstructive and central sleep apneas, intellectual disability, ... -
High-affinity anti-Arc nanobodies provide tools for structural and functional studies
(Journal article; Peer reviewed, 2022)Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals. However, the mechanistic ... -
High-dimensional immunotyping of tumors grown in obese and non-obese mice
(Journal article; Peer reviewed, 2021)Obesity is a disease characterized by chronic low-grade systemic inflammation and has been causally linked to the development of 13 cancer types. Several studies have been undertaken to determine whether tumors evolving ... -
High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia
(Peer reviewed; Journal article, 2018-04)Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished ... -
High-resolution structures of malaria parasite actomyosin and actin filaments
(Journal article; Peer reviewed, 2022-04-04)Malaria is responsible for half a million deaths annually and poses a huge economic burden on the developing world. The mosquito-borne parasites (Plasmodium spp.) that cause the disease depend upon an unconventional ... -
High-salt diet causes osmotic gradients and hyperosmolality in skin without affecting interstitial fluid and lymph
(Peer reviewed; Journal article, 2017-04)The common notion is that the body Na+ is maintained within narrow limits for fluid and blood pressure homeostasis. Several studies have, however, shown that considerable amounts of Na+ can be retained or removed from the ... -
Histological and bacteriological changes in intestine of beluga (Huso huso) following ex vivo exposure to bacterial strains
(Peer reviewed; Journal article, 2011-04-04)In the present study the intestinal sac method (ex vivo) was used to evaluate the interactions between lactic acid bacteria and staphylococci in the gastrointestinal (GI) tract of beluga (Huso huso). The distal intestine ... -
How Does Protein Zero Assemble Compact Myelin?
(Journal article; Peer reviewed, 2020-08)Myelin protein zero (P0), a type I transmembrane protein, is the most abundant protein in peripheral nervous system (PNS) myelin—the lipid-rich, periodic structure of membrane pairs that concentrically encloses long axonal ... -
How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System
(Peer reviewed; Journal article, 2020)A model system of two related enzymes with conserved binding sites, namely N-myristoyltransferase from two different organisms, was studied to decipher the driving forces that lead to selective inhibition in such cases. ... -
Human blood serum proteome changes after 6 hours of sleep deprivation at night
(Journal article; Peer reviewed, 2021)Background The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories ...