Blar i Department of Biomedicine på tittel

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    • Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes 

      Rigg, Emma Kayleigh; Wang, Jiwei; Xue, Zhiwei; Lunavat, Taral; Liu, Guowei; Hoang, Tuyen; Parajuli, Himalaya; Han, Mingzhi; Bjerkvig, Rolf; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Margue, Christiane; Nomigni, Miléne Tetsi; Utikal, Jochen; Miletic, Hrvoje; Sundstrøm, Terje; Ystaas, Lars Andreas Rømo; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2023)
      Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis ...

    • Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis 

      Sundstrøm, Terje; Prestegarden, Lars; Azuaje, Francisco; Aasen, Synnøve Nymark; Røsland, Gro Vatne; Varughese, Jobin K.; Bahador, Marzieh; Bernatz, Simon; Braun, Yannick; Harter, Patrick N.; Skaftnesmo, Kai Ove; Ingham, Elizabeth S.; Mahakian, Lisa M.; Tam, Sarah; Tepper, Clifford G.; Petersen, Kjell; Ferrara, Katherine W.; Tronstad, Karl Johan; Lund-Johansen, Morten; Beschorner, Rudi; Bjerkvig, Rolf; Thorsen, Frits (Peer reviewed; Journal article, 2019-04-10)
      Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ...

    • Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach 

      Dublang, Leire; Underhaug, Jarl; Flydal, Marte Innselset; Velasco-Carneros, Lorea; Maréchal, Jean-Didier; Moro, Fernando; Boyano, Maria Dolores; Martinez, Aurora; Muga, Arturo (Journal article; Peer reviewed, 2021)
      Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ...

    • Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations 

      Betari, Nibal; Sahlholm, Kristoffer; Morató, Xavier; Godoy-Marín, Héctor; Jáuregui, Olga; Teigen, Knut; Ciruela, Francisco; Haavik, Jan (Journal article; Peer reviewed, 2020)
      Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation. 5-HT ...

    • Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone 

      Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut; Martinez, Aurora (Journal article; Peer reviewed, 2022)
      Vesicular monoamine transporter 2 (VMAT2) is responsible for packing monoamine neurotransmitters into synaptic vesicles for storage and subsequent neurotransmission. VMAT2 inhibitors are approved for symptomatic treatment ...

    • Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA_A receptors of A17 amacrine cells in the rat retina 

      Beltran Matas, Pablo; Castilho, Aurea; Tencer, Barbora; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2022)
      Amacrine cells constitute a large and heterogeneous group of inhibitory interneurons in the retina. The A17 amacrine plays an important role for visual signalling in the rod pathway microcircuit of the mammalian retina. ...

    • Innate Lymphoid Cells in Skin Homeostasis and Malignancy 

      Wagner, Marek; Koyasu, Shigeo (Journal article; Peer reviewed, 2021)
      Innate lymphoid cells (ILCs) are mostly tissue resident lymphocytes that are preferentially enriched in barrier tissues such as the skin. Although they lack the expression of somatically rearranged antigen receptors present ...

    • Insights into the cellular role of Serine19 phosphorylation in tyrosine hydroxylase 

      K C, Kunwar Jung (Master thesis, 2016-06-01)
      Tyrosine hydroxylase (TH) is the rate limiting enzyme that catalyzes the first step in the biosynthesis of catecholamines. The posttranslational modification of its regulatory domain controls the regulation of TH enzyme ...

    • Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication 

      Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge; Bergersen, Linda H.; Esbensen, Qin Ying; Sverkeli, Lars Jansen; Ziegler, Mathias; Attramadal, Håvard; Halvorsen, Bente; Aukrust, Pål; Yndestad, Arne (Journal article; Peer reviewed, 2021)
      Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD+) as energy source. Prolonged PARP activity can drain cellular NAD+ reserves, leading to de-regulation ...

    • Insulin and GSK3β-inhibition abrogates the infarct sparing-effect of ischemic postconditioning in ex vivo rat hearts 

      Helgeland, Erik; Wergeland, Anita; Sandøy, Rune Kringstad; Askeland, Maren Haave; Aspevik, Anne; Breivik, Lars Ertesvåg; Jonassen, Anne K (Peer reviewed; Journal article, 2017)
      Objectives. Pharmacological treatment of reperfusion injury using insulin and GSK3β inhibition has been shown to be cardioprotective, however, their interaction with the endogenous cardioprotective strategy, ischemic ...

    • Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders 

      Fanelli, Giuseppe; Franke, Barbara; De Witte, Ward; Ruisch, I. Hyun; Haavik, Jan; van Gils, Veerle; Jansen, Willemijn J.; Vos, Stephanie J. B.; Lind, Lars; Buitelaar, Jan K.; Banaschewski, Tobias; Dalsgaard, Søren; Serretti, Alessandro; Mota, Nina Roth; Poelmans, Geert; Bralten, Janita (Journal article; Peer reviewed, 2022)
      The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and type 2 diabetes mellitus (T2DM), is higher in Alzheimer’s disease (AD), autism spectrum disorder (ASD), and obsessive-compulsive ...

    • Integrating protein structural dynamics and evolutionary analysis with Bio3D 

      Skjærven, Lars; Yao, Xin-Qiu; Scarabelli, Guido; Grant, Barry J. (Peer reviewed; Journal article, 2014-12-10)
      Background: Popular bioinformatics approaches for studying protein functional dynamics include comparisons of crystallographic structures, molecular dynamics simulations and normal mode analysis. However, determining how ...

    • Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts 

      Lerche, Martina; Elosegui-Artola, Alberto; Kechagia, Jenny Z.; Guzmán, Camilo; Georgiadou, Maria; Andreu, Ion; Gullberg, Donald; Roca-Cusachs, Pere; Peuhu, Emilia; Ivaska, Johanna (Journal article; Peer reviewed, 2020)
      The link between integrin activity regulation and cellular mechanosensing of tissue rigidity, especially on different extracellular matrix ligands, remains poorly understood. Here, we find that primary mouse mammary gland ...

    • Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation 

      Murugan Erusappan, Pugazendhi; Alam, Jahedul; Lu, Ning; Zeltz, Cedric; Gullberg, Donald (Peer reviewed; Journal article, 2019)
      Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both ...

    • Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker? 

      Zeltz, Cedric; Navab, Roya; Heljasvaara, Ritva Leena; Gullberg, Marion Kusche; Lu, Ning; Tsao, Ming-Sound; Gullberg, Elon Donald (Journal article; Peer reviewed, 2022)
      There is currently an increased interest in understanding the role of the tumor microenvironment (TME) in tumor growth and progression. In this context the role of integrins in cancer-associated fibroblasts (CAFs) will ...

    • Integrin α11β1 is a receptor for collagen XIII 

      Koivunen, Jarkko; Tu, Hongmin; Kemppainen, Antti; Anbazhagan, Padmanabhan; Finnilä, Mikko A; Saarakkala, Simo; Käpylä, Jarmo; Lu, Ning; Heikkinen, Anne; Juffer, André H; Heino, Jyrki; Gullberg, Donald; Taina, Pihlajaniemi (Journal article; Peer reviewed, 2021)
      Collagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that collagen XIII modulates tissue development and homeostasis. Integrins are a family of receptors ...

    • Intensity-modulated radiotherapy of pelvic lymph nodes in locally advanced prostate cancer: planning procedures and early experiences 

      Muren, Ludvig Paul; Wasbø, Ellen; Helle, Svein Inge; Hysing, Liv Bolstad; Karlsdóttir, Ása; Odland, Odd Harald; Valen, Harald; Ekerold, Randi; Johannesen, Dag Clement (Peer reviewed; Journal article, 2008-07-15)

    • Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling 

      Han, Mingzhi; Wang, Shuai; Fritah, Sabrina; Wang, Xu; Zhou, Wenjing; Yang, Ning; Ni, Shilei; Huang, Bin; Chen, Anjing; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2020)
      Long non-coding RNAs play critical roles in tumour progression. Through analysis of publicly available genomic datasets, we found that MIR22HG, the host gene of microRNAs miR-22-3p and miR-22-5p, is ranked among the most ...

    • Interstitial fluid drainage from rat apical area takes place via vessels in the mandibular canal. 

      Virtej, Anca; Tenstad, Olav; Wiig, Helge; Berggreen, Ellen (Journal article; Peer reviewed, 2020)
      We sought to investigate the transport route for protein‐rich fluid from the apical area towards the draining lymph nodes. The first mandibular molar root canals in 24 female Wistar rats were instrumented and filled with ...

    • Interstitial fluid: the overlooked component of the tumor microenvironment? 

      Wiig, Helge; Tenstad, Olav; Iversen, Per Ole; Kalluri, Raghu; Bjerkvig, Rolf (Peer reviewed; Journal article, 2010-07-23)
      Background: The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on the ...