• AXL is a driver of stemness in normal mammary gland and breast cancer 

      Engelsen, Agnete; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien; Vatter, Fanny A. Pelissier; Tiron, Crina Elena; Villadsen, René; Miyano, Masaru; Lotsberg, Maria Lie; Madeleine, Noëlly; Panahandeh, Pouda; Dhakal, Sushil; Tan, Tuan Zea; Peters, Stacey D'Mello; Grøndal, Sturla Magnus; Aziz, Sura Mohammed; Nord, Silje; Herfindal, Lars; Stampfer, Martha R.; Sørlie, Therese; Brekken, Rolf A; Straume, Oddbjørn; Halberg, Nils; Gausdal, Gro; Thiery, Jean Paul; Akslen, Lars A.; Petersen, Ole W.; LaBarge, Mark A.; Lorens, James (Journal article; Peer reviewed, 2020)
      The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of ...
    • AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells 

      Lotsberg, Maria Lie; Wnuk-Lipinska, Katarzyna; Terry, Stéphane; Tan, Tuan Zea; Lu, Ning; Trachsel-Moncho, Laura; Røsland, Gro Vatne; Siraji, Muntequa Ishtiaq; Hellesøy, Monica; Rayford, Austin James; Jacobsen, Kirstine; Ditzel, Henrik J; Vintermyr, Olav Karsten; Bivona, Trever G; Minna, John; Brekken, Rolf A; Baguley, Bruce; Micklem, David; Akslen, Lars A.; Gausdal, Gro; Simonsen, Anne; Thiery, Jean Paul; Chouaib, Salem; Lorens, James; Engelsen, Agnete (Journal article; Peer reviewed, 2020)
      Introduction Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine ...
    • AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells 

      Li, Huiyu; Liu, Zhida; Liu, Longchao; Zhang, Hongyi; Han, Chuanhui; Girard, Luc; Park, Hyunsil; Zhang, Anli; Dong, Chunbo; Ye, Jianfeng; Rayford, Austin James; Peyton, Michael; Li, Xiaoguang; Avila, Kimberley; Cao, Xuezhi; Hu, Shuiqing; Alam, Md Maksudul; Akbay, Esra A.; Solis, Luisa M.; Behrens, Carmen; Hernandez-Ruiz, Sharia; Lu, Wei; Wistuba, Ignacio; Heymach, John V.; Chisamore, Michael; Micklem, David Robert; Gabra, Hani; Gausdal, Gro; Lorens, James; Li, Bo; Fu, Yang-Xin; Minna, John D.; Brekken, Rolf A. (Journal article; Peer reviewed, 2022)
      Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB), and introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas ...
    • B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion 

      Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Peer reviewed; Journal article, 2015-04)
      Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ...
    • The balance between NAD+ biosynthesis and consumption in ageing 

      Strømland, Øyvind; Diab, Joseph; Ferrario, Eugenio; Sverkeli, Lars Jansen; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ...
    • BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis 

      Kuipers, Sjoukje; Trentani, Andrea; Tiron, Adrian; Mao, Xiaosong; Kuhl, Dietmar; Bramham, Clive R. (Peer reviewed; Journal article, 2016-02-18)
      Adult neurogenesis in the hippocampus is a remarkable phenomenon involved in various aspects of learning and memory as well as disease pathophysiology. Brain-derived neurotrophic factor (BDNF) represents a major player in ...
    • The Benefit of Large Neutral Amino Acid Supplementation to a Liberalized Phenylalanine-Restricted Diet in Adult Phenylketonuria Patients: Evidence from Adult Pah-Enu2 Mice 

      Van Vliet, Danique; van der Goot, Els; van Ginkel, Wiggert G; van Faassen, Martijn H J R; de Blaauw, Pim; Kema, Ido P.; Martinez, Aurora; Heiner-Fokkema, M Rebecca; van der Zee, Eddy A; van Spronsen, Francjan J. (Peer reviewed; Journal article, 2019-09-19)
      Many phenylketonuria (PKU) patients cannot adhere to the severe dietary restrictions as advised by the European PKU guidelines, which can be accompanied by aggravated neuropsychological impairments that, at least in part, ...
    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Peer reviewed; Journal article, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
    • Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery 

      Lingasamy, Prakash; Tobi, Allan; Haugas, Maarja; Hunt, Hedi; Paiste, Paarn; Asser, Toomas; Ratsep, Tonu; Kotamraju, Venkata Ramana; Bjerkvig, Rolf; Teesalu, Tambet (Peer reviewed; Journal article, 2019)
      Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of ...
    • Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders 

      Zhang, Hongyu; Bramham, Clive R. (Journal article; Peer reviewed, 2020-07-10)
      AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal ...
    • Biochemical analysis of novel NAA10 variants suggests distinct pathogenic mechanisms involving impaired protein N‑terminal acetylation 

      McTiernan, Nina; Tranebjærg, Lisbeth; Bjørheim, Anna Steensen; Hogue, Jacob S.; Wilson, William G.; Schmidt, Berkley; Boerrigter, Melissa M.; Nybo, Maja L.; Smeland, Marie; Tümer, Zeynep; Arnesen, Thomas (Journal article; Peer reviewed, 2022)
      NAA10 is the catalytic subunit of the N-terminal acetyltransferase complex, NatA, which is responsible for N-terminal acetylation of nearly half the human proteome. Since 2011, at least 21 different NAA10 missense variants ...
    • BioContainers: An open-source and community-driven framework for software standardization 

      Leprevost, Felipe da Veiga; Grüning, Björn A.; Alves Aflitos, Saulo; Röst, Hannes L.; Uszkoreit, Julian; Barsnes, Harald; Vaudel, Marc; Moreno, Pablo; Gatto, Laurent; Weber, Jonas; Bai, Mingze; Jimenez, Rafael C.; Sachsenberg, Timo; Pfeuffer, Julianus; Vera Alvarez, Roberto; Griss, Johannes; Nesvizhskii, Alexey I.; Perez-Riverol, Yasset (Peer reviewed; Journal article, 2017-03-30)
      Motivation BioContainers (biocontainers.pro) is an open-source and community-driven framework which provides platform independent executable environments for bioinformatics software. BioContainers allows labs of all sizes ...
    • Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers 

      Makumire, Stanley; Zininga, Tawanda; Vahokoski, Juha; Kursula, Inari; Shonhai, Addmore (Journal article; Peer reviewed, 2020)
      Plasmodium falciparum causes the most lethal form of malaria. The cooperation of heat shock protein (Hsp) 70 and 90 is thought to facilitate folding of select group of cellular proteins that are crucial for cyto-protection ...
    • Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival 

      Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn; Engelsen, Agnete; Bindesbøll, Christian; Sarowar, Shahin; Bahador, Marzieh; Bifulco, Ersilia; Goplen, Dorota; Waha, Andreas; Lie, Stein Atle; Gjertsen, Bjørn Tore; Selheim, Frode; Enger, Per Øyvind; Simonsen, Anne; Enger, Martha Chekenya (Peer reviewed; Journal article, 2019-08-15)
      Background Resistance to temozolomide (TMZ) is due in part to enhanced DNA repair mediated by high expression of O6-methyl guanine DNA methyltransferase (MGMT) that is often characterised by unmethylated promoter. Here, ...
    • C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer 

      Liu, Xiaozheng; Rulina, Anastasiia; Choi, Man Hung; Pedersen, Line; Lepland, Johanna; Takle, Sina Thorsen; Madeleine, Noëlly; Peters, Stacey D'mello; Wogsland, Cara Ellen; Grøndal, Sturla Magnus; Lorens, James Bradley; Goodarzi, Hani; Lønning, Per Eystein; Knappskog, Stian; Molven, Anders; Halberg, Nils Henrik (Journal article; Peer reviewed, 2022)
      Epidemiological studies have established a positive association between obesity and the incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes stem cell-like properties of breast cancer ...
    • Cabozantinib is effective in melanoma brain metastasis cell lines and affects key signaling pathways 

      Mannsåker, Trond Are; Hoang, Tuyen; Aasen, Synnøve Nymark; Bjørnstad, Ole Vidhammer; Parajuli, Himalaya; Sundstrøm, Terje; Thorsen, Frits (Journal article; Peer reviewed, 2021-11-14)
      Melanomas have a high potential to metastasize to the brain. Recent advances in targeted therapies and immunotherapies have changed the therapeutical landscape of extracranial melanomas. However, few patients with melanoma ...
    • Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines 

      Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-11-13)
      Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ...
    • Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies 

      Sakariassen, Per Øystein; Immervoll, Heike; Chekenya, Martha (Peer reviewed; Journal article, 2007-11)
      Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ...
    • Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins 

      Zeltz, Cedric; Primac, Irina; Murugan Erusappan, Pugazendhi; Alam, Jahedul; Noel, Agnes; Gullberg, Donald (Peer reviewed; Journal article, 2019)
      The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle ...
    • A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study 

      Hegvik, Tor-Arne; Jacobsen, Kaya Kvarme; Fredriksen, Mats; Zayats, Tetyana; Haavik, Jan (Peer reviewed; Journal article, 2016-08)
      Attention-deficit/hyperactivity disorder (ADHD) is a common childhood onset neuropsychiatric disorder with a complex and heterogeneous symptomatology. Persistence of ADHD symptoms into adulthood is common. Methylphenidate ...