Now showing items 493-512 of 527

    • Toward understanding scarless skin wound healing and pathological scarring 

      Karppinen, Sanna-Maria; Heljasvaara, Ritva Leena; Gullberg, Donald; Tasanen, Kaisa; Pihlajaniemi, Taina (Peer reviewed; Journal article, 2019)
      The efficient healing of skin wounds is crucial for securing the vital barrier function of the skin, but pathological wound healing and scar formation are major medical problems causing both physiological and psychological ...
    • Toxicity and tropism of oncolytic VSV vectors in glioblastoma gene therapy 

      Zehtab Jahedi, Roza (Master thesis, 2012-11-05)
      Glioblastoma multiforme is the most common and most fatal primary brain tumor in adults. Despite using advanced conventional therapeutic approaches like surgical resection, radiotherapy and chemotherapy only marginal ...
    • Transcriptional and epigenetic mechanisms underlying astrocyte identity 

      Pavlou, Maria Angeliki S.; Grandbarbe, Luc; Buckley, Noel J.; Niclou, Simone Pierrette; Michelucci, Alessandro (Peer reviewed; Journal article, 2019-03)
      Astrocytes play a significant role in coordinating neural development and provide critical support for the function of the CNS. They possess important adaptation capacities that range from their transition towards reactive ...
    • Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells 

      Wang, Xiang; Gerdes, Hans-Hermann (Peer reviewed; Journal article, 2015-01-09)
      Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, ...
    • Translational regulation in the adult brain: mediated by BDNF signalling, stress, and chronic antidepressant treatment 

      Dagestad, Grethe (Doctoral thesis, 2010-09-01)
      One of the most amazing features of the brain is its plasticity. This is a fundamental process by which the brain acquires information and makes the appropriate adaptive changes, a process that makes us able to think, feel, ...
    • Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization 

      Zhang, Xin; Ding, Kaikai; Ji, Jianxiong; Parajuli, Himalaya; Aasen, Synnøve Nymark; Espedal, Heidi; Huang, Bin; Chen, Anjing; Wang, Jian; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2020)
      Brain metastasis is a major cause of mortality in melanoma patients. The blood-brain barrier (BBB) prevents most anti-tumor compounds from entering the brain, which significantly limits their use in the treatment of brain ...
    • Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination 

      Zhang, Xin; Xu, Ran; Zhang, Chao; Xu, Yangyang; Han, Mingzhi; Huang, Bin; Chen, Anjing; Qiu, Chen; Thorsen, Frits; Prestegarden, Lars; Bjerkvig, Rolf; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2017-09-05)
      Background: Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid ...
    • TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα 

      Ji, Jianxiong; Ding, Kaikai; Luo, Tao; Zhang, Xin; Chen, Anjing; Zhang, Di; Li, Gang; Thorsen, Frits; Huang, Bin; Li, Xingang; Wang, Jian (Journal article; Peer reviewed, 2021)
      NF-κB signaling plays a critical role in tumor growth and treatment resistance in GBM as in many other cancers. However, the molecular mechanisms underlying high, constitutive NF-κB activity in GBM remains to be elucidated. ...
    • Tumor interstitial fluid formation, characterization, and clinical implications 

      Wagner, Marek; Wiig, Helge (Peer reviewed; Journal article, 2015-05-26)
      The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase representing the tissue microenvironment. In the present review, we focus on the interstitial ...
    • Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s 

      Wagner, Marek; Ealey, Kafi N; Tetsu, Hiroe; Kiniwa, Tsuyoshi; Motomura, Yasutaka; Moro, Kazuyo; Koyasu, Shigeo (Journal article; Peer reviewed, 2020)
      Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a relatively small proportion of immune ...
    • Tumor-penetrating peptide for systemic targeting of Tenascin-C 

      Lingasamy, Prakash; Tobi, Allan; Kurm, Kaarel; Kopanchuk, Sergei; Sudakov, Aleksander; Salumäe, Markko; Rätsep, Tõnu; Asser, Toomas; Bjerkvig, Rolf; Teesalu, Tambet (Journal article; Peer reviewed, 2020)
      Extracellular matrix in solid tumors has emerged as a specific, stable, and abundant target for affinity-guided delivery of anticancer drugs. Here we describe the homing peptide that interacts with the C-isoform of Tenascin-C ...
    • Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts 

      Leiss, Lina Wik; Mutlu, Ercan; Øyan, Anne Margrete; Yan, Tao; Tsinkalovsky, Oleg; Sleire, Linda; Petersen, Kjell; Rahman, Mohummad Aminur; Johannessen, Mireille Kayitesi; Mitra, Siddharta S.; Jacobsen, Hege; Talasila, Krishna Mukharji; Miletic, Hrvoje; Jonassen, Inge; Li, Xingang; Brons, Nicolas H.C.; Kalland, Karl-Henning; Wang, Jian; Enger, Per Øyvind (Peer reviewed; Journal article, 2017-02-07)
      Background: Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. Methods: We isolated stromal cells from patient-derived ...
    • Tunneling nanotubes: Diversity in morphology and structure 

      Austefjord, Magnus Wiger; Gerdes, Hans-Hermann; Wang, Xiang (Peer reviewed; Journal article, 2014-02-06)
      Tunneling nanotubes (TNTs) are recently discovered thin membranous tubes that interconnect cells. During the last decade, research has shown TNTs to be diverse in morphology and composition, varying between and within cell ...
    • Two tales of Annexin A2 knock-down: One of compensatory effects by antisense RNA and another of a highly active hairpin ribozyme 

      Aareskjold, Elin; Grindheim, Ann Kari; Hollås, Hanne; Goris, Marianne; Lillehaug, Johan R.; Vedeler, Anni (Peer reviewed; Journal article, 2019-05-31)
      Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the progression of many cancer types and also plays key roles during viral infection and multiplication. Consequently, there ...
    • Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK 

      Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura; Zalfa, Francesca; Vedeler, Anni; Wibrand, Karin; Fukunaga, Rikiro; Bagni, Claudia; Proud, Christopher G.; Bramham, Clive R. (Peer reviewed; Journal article, 2014-11-20)
      BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ...
    • Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease 

      Waløen, Kai; Kleppe, Rune; Martinez, Aurora; Haavik, Jan (Peer reviewed; Journal article, 2017)
      Introduction: The ancient and ubiquitous monoamine signalling molecules serotonin, dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions. The aromatic amino acid hydroxylases tyrosine ...
    • Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis 

      Barone, Helene; Bliksrud, Yngve Thomas; Elgen, Irene Bircow; Szigetvari, Peter Daniel; Kleppe, Rune; Ghorbani, Sadaf; Hansen, Eirik Vangsøy; Haavik, Jan (Peer reviewed; Journal article, 2019-10-21)
      Hereditary tyrosinemia Type 1 (HT‐1) is a rare metabolic disease where the enzyme catalyzing the final step of tyrosine breakdown is defect, leading to accumulation of toxic metabolites. Nitisinone inhibits the degradation ...
    • U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells 

      Torsvik, Anja; Stieber, Daniel; Enger, Per Øyvind; Golebiewska, Anna; Molven, Anders; Svendsen, Agnete; Westermark, Bengt; Niclou, Simone P.; Olsen, Thale Kristin; Chekenya, PhD, Dr Philos, Dr. Martha; Bjerkvig, Rolf (Peer reviewed; Journal article, 2014-08)
      It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination ...
    • UCP1 induction during recruitment of Brown Adipocytes in White Adipose tissue is dependent on Cyclooxygenase activity 

      Madsen, Lise; Pedersen, Lone M.; Lillefosse, Haldis Haukaas; Fjære, Even; Brønstad, Ingeborg; Hao, Qin; Petersen, Rasmus Koefoed; Hallenborg, Philip; Ma, Tao; De Matteis, Rita; Araujo, Pedro; Mercader, Josep; Bonet, M. Luisa; Hansen, Jacob B.; Cannon, Barbara; Nedergaard, Jan; Wang, Jun; Cinti, Saverio; Voshol, Peter; Døskeland, Stein Ove; Kristiansen, Karsten (Peer reviewed; Journal article, 2010-06-30)
      Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and ...