Browsing Department of Biomedicine by Title
Now showing items 505-524 of 812
-
Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies
(Peer reviewed; Journal article, 2014-09-30)The vastmajority ofmalignant gliomas relapse after surgery and standard radio-chemotherapy. Novelmolecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth.While histopathology ... -
Multimodal Imaging of Physiologic Changes Induced by Anti-Angiogenic Therapy in Glioblastoma
(Doctoral thesis, 2014-12-18)Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ... -
Multiparametric brain MRI and deep learning models applied to segmentation and prediction in patients with glioma
(Doctoral thesis, 2024-08-28)Avhandlingen undersøker metoder og algoritmer for hjernetumor (gliom) segmenter- ing, med prediksjon av histologisk gradering, og anatomisk profilering fra MR-bilder. En viktig motivasjon for dette arbeidet har vært ... -
Multiphoton excitation microscopy for the reconstructionand analysis of single neuron morphology
(Neuromethods, Chapter; Peer reviewed, 2019)Neurons are the main cellular components of the circuits of the central nervous system (CNS). The dendritic and axonal morphology of individual neurons display marked variability between neurons in different regions of the ... -
Multiple sclerosis and myelin basic protein: insights into protein disorder and disease
(Journal article; Peer reviewed, 2022)Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin. MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS). MS ... -
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin
(Peer reviewed; Journal article, 2019-12-16)IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), ... -
Myelin proteins from the peripheral nervous system : Structures and interactions with lipid membrane
(Doctoral thesis, 2024-08-29)Saltare (å hoppe) beskriver den grunnleggende funksjonen myelin har i nervesystemet. Myelin er en flerlaget fettmembran som omslutter nervecellenes aksoner og effektiviserer signalformidlingen betraktelig ved å øke hastigheten ... -
Myelin-derived and putative molecular mimic peptides share structural properties in aqueous and membrane-like environments
(Peer reviewed; Journal article, 2017-03-24)Background: Despite intense research, the causes of various neurological diseases remain enigmatic to date. A role for viral or bacterial infection and associated molecular mimicry has frequently been suggested in the ... -
The mzIdentML data standard version 1.2, supporting advances in proteome informatics
(Peer reviewed; Journal article, 2017-07-01)The first stable version of the Proteomics Standards Initiative mzIdentML open data standard (version 1.1) was published in 2012—capturing the outputs of peptide and protein identification software. In the intervening ... -
N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus
(Journal article; Peer reviewed, 2020)N-alpha-acetyltransferase 80 (NAA80) was recently demonstrated to acetylate the N-terminus of actin, with NAA80 knockout cells showing actin cytoskeleton-related phenotypes, such as increased formation of membrane protrusions ... -
N-terminal cysteine acetylation and oxidation patterns may define protein stability
(Journal article; Peer reviewed, 2024)Oxygen homeostasis is maintained in plants and animals by O2-sensing enzymes initiating adaptive responses to low O2 (hypoxia). Recently, the O2-sensitive enzyme ADO was shown to initiate degradation of target proteins ... -
The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes
(Peer reviewed; Journal article, 2014-01-09)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamine neurotransmitters, and a reduction in TH activity is associated with several neurological diseases. Human TH is regulated, among ... -
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats
(Journal article; Peer reviewed, 2022)Recently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated whether there were electrolyte gradients ... -
NAA10 p.(D10G) and NAA10 p.(L11R) variants hamper formation of the NatA N-terminal acetyltransferase complex
(Journal article; Peer reviewed, 2020)The majority of the human proteome is subjected to N-terminal (Nt) acetylation catalysed by N-terminal acetyltransferases (NATs). The NatA complex is composed of two core subunits—the catalytic subunit NAA10 and the ribosomal ... -
NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy
(Journal article; Peer reviewed, 2020)Nearly half of all human proteins are acetylated at their N-termini by the NatA N-terminal acetyltransferase complex. NAA10 is evolutionarily conserved as the catalytic subunit of NatA in complex with NAA15, but may also ... -
Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish
(Journal article; Peer reviewed, 2024)Actin is a critical component of the eukaryotic cytoskeleton. In animals, actins undergo unique N-terminal processing by dedicated enzymes resulting in mature acidic and acetylated forms. The final step, N-terminal ... -
A Nanobody-Based Proximity Ligation Assay Detects Constitutive and Stimulus-Regulated Native Arc/Arg3.1 Oligomers in Hippocampal Neuronal Dendrites
(Journal article; Peer reviewed, 2024)Activity-regulated cytoskeleton-associated protein (Arc), the product of an immediate early gene, plays critical roles in synaptic plasticity and memory. Evidence suggests that Arc function is determined by its oligomeric ... -
Natalizumab promotes anti-inflammatory and repair effects in multiple sclerosis
(Journal article; Peer reviewed, 2024)Background Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system leading to demyelination and axonal loss. Relapsing-remitting multiple sclerosis (RRMS) is commonly treated by ... -
The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects
(Peer reviewed; Journal article, 2015-03-13)The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ... -
The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma
(Peer reviewed; Journal article, 2019-09-27)Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the molecular basis for its ...