Blar i Department of Biomedicine på tittel
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Tumor oxygenation - influence on mammary tumor growth, progression and response to chemotherapy
(Doctoral thesis, 2011-04-28) -
Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s
(Journal article; Peer reviewed, 2020)Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a relatively small proportion of immune ... -
Tumor-penetrating peptide for systemic targeting of Tenascin-C
(Journal article; Peer reviewed, 2020)Extracellular matrix in solid tumors has emerged as a specific, stable, and abundant target for affinity-guided delivery of anticancer drugs. Here we describe the homing peptide that interacts with the C-isoform of Tenascin-C ... -
Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
(Peer reviewed; Journal article, 2017-02-07)Background: Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers. Methods: We isolated stromal cells from patient-derived ... -
Tunneling nanotubes: Diversity in morphology and structure
(Peer reviewed; Journal article, 2014-02-06)Tunneling nanotubes (TNTs) are recently discovered thin membranous tubes that interconnect cells. During the last decade, research has shown TNTs to be diverse in morphology and composition, varying between and within cell ... -
Two tales of Annexin A2 knock-down: One of compensatory effects by antisense RNA and another of a highly active hairpin ribozyme
(Peer reviewed; Journal article, 2019-05-31)Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the progression of many cancer types and also plays key roles during viral infection and multiplication. Consequently, there ... -
Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK
(Peer reviewed; Journal article, 2014-11-20)BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ... -
Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease
(Peer reviewed; Journal article, 2017)Introduction: The ancient and ubiquitous monoamine signalling molecules serotonin, dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions. The aromatic amino acid hydroxylases tyrosine ... -
Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis
(Peer reviewed; Journal article, 2019-10-21)Hereditary tyrosinemia Type 1 (HT‐1) is a rare metabolic disease where the enzyme catalyzing the final step of tyrosine breakdown is defect, leading to accumulation of toxic metabolites. Nitisinone inhibits the degradation ... -
U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells
(Peer reviewed; Journal article, 2014-08)It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination ... -
UCP1 induction during recruitment of Brown Adipocytes in White Adipose tissue is dependent on Cyclooxygenase activity
(Peer reviewed; Journal article, 2010-06-30)Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
(Peer reviewed; Journal article, 2018-01-16)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ... -
Understanding the interaction between the co-chaperone DNAJC12 and tyrosine hydroxylase
(Master thesis, 2020-06-23) -
Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation
(Peer reviewed; Journal article, 2019)Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production. Regulation occurs through multiple nutrient- and energy-sensitive molecular mechanisms. We explored if upregulated mRNA expression of the ... -
Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib
(Journal article; Peer reviewed, 2020)Ursodeoxycholic acid (UDCA) has demonstrated cancer suppressive potential in several tumors. Here, we investigated the antitumor potential and biochemical mechanism of UDCA on glioblastoma multiforme (GBM), the deadliest ... -
Use of stable isotope dimethyl labeling coupled to selected reaction monitoring to enhance throughput by multiplexing relative quantitation of targeted proteins
(Peer reviewed; Journal article, 2012)In this manuscript, we present a proof-of-concept study for targeted relative protein quantitation workflow using chemical labeling in the form of dimethylation, coupled with selected reaction monitoring (dimethyl-SRM). ... -
Using mass spectrometry-based proteomics to improve the understanding of multiple sclerosis treatments
(Doctoral thesis, 2021-06-23)In this work, the effects of multiple sclerosis (MScl) treatments were investigated by quantitative proteomics. First, the effects of the anti-inflammatory drug Fingolimod was studied to see if the drug affected central ... -
Validity and accuracy of the Adult Attention-Deficit/Hyperactivity Disorder (ADHD) Self-Report Scale (ASRS) and the Wender Utah Rating Scale (WURS) symptom checklists in discriminating between adults with and without ADHD
(Journal article; Peer reviewed, 2020)Objective To validate the Adult ADHD Self‐Report Scale (ASRS) and the Wender Utah Rating Scale (WURS) in a well‐characterized sample of adult attention‐deficit/hyperactivity disorder (ADHD) patients and population ... -
Vascular endothelial growth factors and receptors - from normal dental pulp to apical pathology
(Doctoral thesis, 2016-02-12)The VEGFs -A, -B, -C, -D are important signaling molecules with pivotal implication in the growth of blood and lymphatic vessels, the so-called angio- and lymphangiogenesis. They exert their activities by binding to their ... -
Viewing the proteome: How to visualize proteomics data?
(Peer reviewed; Journal article, 2015-04)Proteomics has become one of the main approaches for analyzing and understanding biological systems. Yet similar to other high-throughput analysis methods, the presentation of the large amounts of obtained data in easily ...